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fibroblast growth factor receptor 2
Summary
- Gene Symbol
-
- FGFR2
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- ATP-binding
- Alternative splicing
- Apoptosis
- Cell membrane
- Craniosynostosis
- Cytoplasmic vesicle
- Disease variant
- Disulfide bond
- Glycoprotein
- Golgi apparatus
- Heparin-binding
- Immunoglobulin domain
- Intellectual disability
- Lacrimo-auriculo-dento-digital syndrome
- Phosphoprotein
- Proteomics identification
- Proto-oncogene
- Receptor
- Reference proteome
- Repeat
- Secreted
- Signal
- Transmembrane helix
- Tyrosine-protein kinase
- Ubl conjugation
- Proteins
| UniProt | Protein Name |
|---|---|
| P21802 |
|
| D2CGD1 |
|
| S4R381 |
|
| A0A141AXF1 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| apoptotic process | ||
| epidermal growth factor receptor signaling pathway | ||
| cell-cell signaling | ||
| axonogenesis | ||
| positive regulation of cell population proliferation |
GO Hierarchy
- insulin receptor signaling pathway
- fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow cell
- fibroblast growth factor receptor signaling pathway involved in hemopoiesis
- fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow
- fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development
- fibroblast growth factor receptor signaling pathway involved in mammary gland specification
- brain-derived neurotrophic factor receptor signaling pathway
- collagen-activated tyrosine kinase receptor signaling pathway
- vascular endothelial growth factor signaling pathway
- Kit signaling pathway
- insulin-like growth factor receptor signaling pathway
- hepatocyte growth factor receptor signaling pathway
- ephrin receptor signaling pathway
- insulin receptor signaling pathway
- fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow cell
- fibroblast growth factor receptor signaling pathway involved in hemopoiesis
- fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow
- fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development
- fibroblast growth factor receptor signaling pathway involved in mammary gland specification
- brain-derived neurotrophic factor receptor signaling pathway
- collagen-activated tyrosine kinase receptor signaling pathway
- vascular endothelial growth factor signaling pathway
- Kit signaling pathway
- insulin-like growth factor receptor signaling pathway
- hepatocyte growth factor receptor signaling pathway
- ephrin receptor signaling pathway
biological process
metabolic process [inference]
cellular process [inference]
signal transduction [inference]
cell surface receptor signaling pathway [inference]
enzyme-linked receptor protein signaling pathway [inference]
transmembrane receptor protein tyrosine kinase signaling pathway [inference]
fibroblast growth factor receptor signaling pathway
reproductive process [inference]
developmental process [inference]
developmental process involved in reproduction [inference]
anatomical structure morphogenesis [inference]
anatomical structure development [inference]
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
negative regulation of metabolic process [inference]
positive regulation of metabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of signaling [inference]
regulation of growth [inference]
positive regulation of biological process [inference]
positive regulation of metabolic process [inference]
positive regulation of cellular process [inference]
negative regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of developmental process [inference]
regulation of cellular process [inference]
signal transduction [inference]
cell surface receptor signaling pathway [inference]
enzyme-linked receptor protein signaling pathway [inference]
transmembrane receptor protein tyrosine kinase signaling pathway [inference]
fibroblast growth factor receptor signaling pathway
regulation of cell communication [inference]
regulation of cellular metabolic process [inference]
regulation of cell population proliferation [inference]
positive regulation of cellular process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| extracellular region | ||
| nucleus | ||
| cytoplasm | ||
| Golgi apparatus | ||
| plasma membrane |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein tyrosine kinase activity | ||
| GPI-linked ephrin receptor activity | ||
| transmembrane-ephrin receptor activity | ||
| epidermal growth factor receptor activity | ||
| fibroblast growth factor receptor activity |
GO Hierarchy
- epidermal growth factor receptor activity
- fibroblast growth factor receptor activity
- hepatocyte growth factor receptor activity
- insulin receptor activity
- insulin-like growth factor receptor activity
- macrophage colony-stimulating factor receptor activity
- stem cell factor receptor activity
- vascular endothelial growth factor receptor activity
- boss receptor activity
- placental growth factor receptor activity
- protein tyrosine kinase collagen receptor activity
- brain-derived neurotrophic factor receptor activity
- epidermal growth factor receptor activity
- fibroblast growth factor receptor activity
- hepatocyte growth factor receptor activity
- insulin receptor activity
- insulin-like growth factor receptor activity
- macrophage colony-stimulating factor receptor activity
- stem cell factor receptor activity
- vascular endothelial growth factor receptor activity
- boss receptor activity
- placental growth factor receptor activity
- protein tyrosine kinase collagen receptor activity
- brain-derived neurotrophic factor receptor activity
- epidermal growth factor receptor activity
- fibroblast growth factor receptor activity
- hepatocyte growth factor receptor activity
- insulin receptor activity
- insulin-like growth factor receptor activity
- macrophage colony-stimulating factor receptor activity
- stem cell factor receptor activity
- vascular endothelial growth factor receptor activity
- boss receptor activity
- placental growth factor receptor activity
- protein tyrosine kinase collagen receptor activity
- brain-derived neurotrophic factor receptor activity
- epidermal growth factor receptor activity
- fibroblast growth factor receptor activity
- hepatocyte growth factor receptor activity
- insulin receptor activity
- insulin-like growth factor receptor activity
- macrophage colony-stimulating factor receptor activity
- stem cell factor receptor activity
- vascular endothelial growth factor receptor activity
- boss receptor activity
- placental growth factor receptor activity
- protein tyrosine kinase collagen receptor activity
- brain-derived neurotrophic factor receptor activity
- epidermal growth factor receptor activity
- fibroblast growth factor receptor activity
- hepatocyte growth factor receptor activity
- insulin receptor activity
- insulin-like growth factor receptor activity
- macrophage colony-stimulating factor receptor activity
- stem cell factor receptor activity
- vascular endothelial growth factor receptor activity
- boss receptor activity
- placental growth factor receptor activity
- protein tyrosine kinase collagen receptor activity
- brain-derived neurotrophic factor receptor activity
- epidermal growth factor receptor activity
- fibroblast growth factor receptor activity
- hepatocyte growth factor receptor activity
- insulin receptor activity
- insulin-like growth factor receptor activity
- macrophage colony-stimulating factor receptor activity
- stem cell factor receptor activity
- vascular endothelial growth factor receptor activity
- boss receptor activity
- placental growth factor receptor activity
- protein tyrosine kinase collagen receptor activity
- brain-derived neurotrophic factor receptor activity
- epidermal growth factor receptor activity
- fibroblast growth factor receptor activity
- hepatocyte growth factor receptor activity
- insulin receptor activity
- insulin-like growth factor receptor activity
- macrophage colony-stimulating factor receptor activity
- stem cell factor receptor activity
- vascular endothelial growth factor receptor activity
- boss receptor activity
- placental growth factor receptor activity
- protein tyrosine kinase collagen receptor activity
- brain-derived neurotrophic factor receptor activity
molecular function
catalytic activity [inference]
transferase activity [inference]
transferase activity, transferring phosphorus-containing groups [inference]
kinase activity [inference]
protein kinase activity [inference]
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity [inference]
transmembrane receptor protein kinase activity [inference]
transmembrane receptor protein tyrosine kinase activity [inference]
phosphotransferase activity, alcohol group as acceptor [inference]
protein kinase activity [inference]
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity [inference]
transmembrane receptor protein kinase activity [inference]
transmembrane receptor protein tyrosine kinase activity [inference]
catalytic activity, acting on a protein [inference]
protein kinase activity [inference]
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity [inference]
transmembrane receptor protein kinase activity [inference]
transmembrane receptor protein tyrosine kinase activity [inference]
binding [inference]
molecular transducer activity [inference]
signaling receptor activity [inference]
transmembrane signaling receptor activity [inference]
transmembrane receptor protein kinase activity [inference]
transmembrane receptor protein tyrosine kinase activity [inference]
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- fibroblast growth factor receptor
- Functional Category
-
- M: Cell wall/membrane/envelope biogenesis
- O: Posttranslational modification, protein turnover, chaperones
- T: Signal transduction mechanisms
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050331 | lacrimoauriculodentodigital syndrome 1 | |
| DOID:0050660 | Beare-Stevenson cutis gyrata syndrome | |
| DOID:0050861 | colorectal adenocarcinoma | |
| DOID:0060992 | bent bone dysplasia syndrome 1 | |
| DOID:0081289 | Antley-Bixler syndrome | |
| DOID:0081290 | Antley-Bixler syndrome without disordered steroidogenesis | |
| DOID:0111337 | Jackson-Weiss syndrome | |
| DOID:10534 | stomach cancer | |
| DOID:11054 | urinary bladder cancer | |
| DOID:12960 | acrocephalosyndactylia |
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 105554550 | MANLE04656 | ||
| 105577985 | CERAT13319 | ||
| 105717989 | AOTNA24567 | ||
| 105808669 | PROCO14789 | ||
| 105870804 | MICMU11821 | ||
| 105989771 | DIPOR13065 | ||
| 106576891 | SALSA57198 | ||
| 106846935 | EQUAS12112 | ||
| 107597642 | SINGR24775 | ||
| 108263349 | ICTPU27293 |
