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FERM, RhoGEF and pleckstrin domain protein 2

Summary

Gene Symbol

Farp2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

227377

PubChem

227377

Alliance of Genome Resources

MGI:2385126

Annotation

Keyword

3D-structure
Guanine-nucleotide releasing factor
Phosphoprotein
Reference proteome
Repeat

Proteins

Displaying 1 entry
UniProt	Protein Name
Q91VS8	FERM domain including RhoGEF FERM, RhoGEF and pleckstrin domain-containing protein 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
cell adhesion	IMP	20702777
neuron remodeling	ISO	12351724
Rac protein signal transduction	ISO	12351724
hair cycle process	IMP	25340873
actin cytoskeleton organization	IMP	20702777

GO Hierarchy

biological process

cellular process [inference]

cell adhesion

signal transduction [inference]

cell surface receptor signaling pathway [inference]

semaphorin-plexin signaling pathway

intracellular signal transduction [inference]

small GTPase mediated signal transduction [inference]

Ras protein signal transduction [inference]

Rac protein signal transduction

actin filament-based process [inference]

actin cytoskeleton organization

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

myeloid leukocyte differentiation [inference]

osteoclast differentiation

myeloid cell differentiation [inference]

myeloid leukocyte differentiation [inference]

osteoclast differentiation

cell maturation [inference]

neuron maturation [inference]

neuron remodeling

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

actin cytoskeleton organization

organelle assembly [inference]

non-membrane-bounded organelle assembly [inference]

podosome assembly

cellular component assembly [inference]

protein-containing complex assembly [inference]

podosome assembly

organelle assembly [inference]

non-membrane-bounded organelle assembly [inference]

podosome assembly

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

podosome assembly

multicellular organismal process [inference]

molting cycle process [inference]

hair cycle process

developmental process [inference]

developmental maturation [inference]

anatomical structure maturation [inference]

cell maturation [inference]

neuron maturation [inference]

neuron remodeling

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

myeloid leukocyte differentiation [inference]

osteoclast differentiation

myeloid cell differentiation [inference]

myeloid leukocyte differentiation [inference]

osteoclast differentiation

cell maturation [inference]

neuron maturation [inference]

neuron remodeling

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

semaphorin-plexin signaling pathway

intracellular signal transduction [inference]

small GTPase mediated signal transduction [inference]

Ras protein signal transduction [inference]

Rac protein signal transduction

regulation of cellular component biogenesis [inference]

regulation of protein-containing complex assembly [inference]

regulation of integrin activation

regulation of cellular component organization [inference]

regulation of protein-containing complex assembly [inference]

regulation of integrin activation

Displaying **all 3** entries
GO Term	Evidence Code	PMID
cytoplasm	ISO	12351724
cytosol	TAS
cytoskeleton	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

Displaying **all 5** entries
GO Term	Evidence Code	PMID
guanyl-nucleotide exchange factor activity	ISO	12351724
guanyl-nucleotide exchange factor activity	TAS
guanyl-nucleotide exchange factor activity	IDA	23375260
guanyl-nucleotide exchange factor activity	IBA
cytoskeletal protein binding	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

cytoskeletal protein binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

nucleoside-triphosphatase regulator activity [inference]

GTPase regulator activity [inference]

guanyl-nucleotide exchange factor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ferm

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying entries **1 - 10** of 14 in total

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InterPro
Band 4.1 domain
Dbl homology (DH) domain superfamily
Dbl homology (DH) domain
FARP1/FARP2/FRMD7, FERM domain C-lobe
FERM adjacent
FERM central domain
FERM domain
FERM superfamily, second domain
FERM, C-terminal PH-like domain
FERM, N-terminal

Ortholog

Displaying entries **1 - 10** of 87 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	9855		HUMAN68051
Caenorhabditis elegans	10160	WB:WBGene00001490
Caenorhabditis elegans	223254	WB:WBGene00001490
Danio rerio	227377	ZFIN:ZDB-GENE-030131-2993
Rattus norvegicus	316639		RATNO42980
Pan troglodytes	460083		PANTR30247
Canis lupus familiaris	486205		CANLF10180
Danio rerio	567490		DANRE38000
Macaca mulatta	701179		MACMU05665
Equus caballus	100067721		HORSE36959