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mannosidase, alpha, class 1B, member 1

Summary

Gene Symbol

Man1b1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

227619

PubChem

227619

Alliance of Genome Resources

MGI:2684954

Annotation

Keyword

Calcium
Disulfide bond
Endoplasmic reticulum
Glycosidase
Metal-binding
Phosphoprotein
Reference proteome
Signal-anchor
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
A2AJ15	ER alpha-1,2-mannosidase ER mannosidase 1 Man9GlcNAc2-specific-processing alpha-mannosidase Mannosidase alpha class 1B member 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
ERAD pathway	IMP ISO	15294975
carbohydrate metabolic process	IEA
mannose trimming involved in glycoprotein ERAD pathway	IBA
mannoprotein catabolic process	ISO
metabolic process	IEA

GO Hierarchy

biological process

metabolic process

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

mannoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

glycoprotein metabolic process [inference]

mannoprotein metabolic process [inference]

mannoprotein catabolic process

glycoprotein catabolic process [inference]

mannoprotein catabolic process

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein catabolic process [inference]

glycoprotein catabolic process [inference]

mannoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

protein modification process [inference]

protein glycosylation

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

mannose trimming involved in glycoprotein ERAD pathway

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process [inference]

mannoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process [inference]

mannoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

carbohydrate derivative catabolic process [inference]

glycoprotein catabolic process [inference]

mannoprotein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process [inference]

mannoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

primary metabolic process [inference]

carbohydrate metabolic process

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

mannoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

glycoprotein metabolic process [inference]

mannoprotein metabolic process [inference]

mannoprotein catabolic process

glycoprotein catabolic process [inference]

mannoprotein catabolic process

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein catabolic process [inference]

glycoprotein catabolic process [inference]

mannoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

protein modification process [inference]

protein glycosylation

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

mannose trimming involved in glycoprotein ERAD pathway

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation

organic substance metabolic process [inference]

carbohydrate metabolic process

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process [inference]

mannoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

mannoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

glycoprotein metabolic process [inference]

mannoprotein metabolic process [inference]

mannoprotein catabolic process

glycoprotein catabolic process [inference]

mannoprotein catabolic process

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein catabolic process [inference]

glycoprotein catabolic process [inference]

mannoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

protein modification process [inference]

protein glycosylation

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

mannose trimming involved in glycoprotein ERAD pathway

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

mannose trimming involved in glycoprotein ERAD pathway

macromolecule glycosylation [inference]

protein glycosylation

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process [inference]

mannoprotein metabolic process [inference]

mannoprotein catabolic process

glycoprotein catabolic process [inference]

mannoprotein catabolic process

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

mannose trimming involved in glycoprotein ERAD pathway

carbohydrate derivative catabolic process [inference]

glycoprotein catabolic process [inference]

mannoprotein catabolic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

mannoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

glycoprotein metabolic process [inference]

mannoprotein metabolic process [inference]

mannoprotein catabolic process

glycoprotein catabolic process [inference]

mannoprotein catabolic process

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein catabolic process [inference]

glycoprotein catabolic process [inference]

mannoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

protein modification process [inference]

protein glycosylation

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

mannose trimming involved in glycoprotein ERAD pathway

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process [inference]

mannoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process [inference]

mannoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

carbohydrate derivative catabolic process [inference]

glycoprotein catabolic process [inference]

mannoprotein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process [inference]

mannoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

cellular process [inference]

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

ERAD pathway

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

ERAD pathway

response to chemical [inference]

response to organic substance [inference]

response to organonitrogen compound [inference]

ERAD pathway

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

ERAD pathway

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

ERAD pathway

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
endosome
endoplasmic reticulum	IBA ISO
trans-Golgi network
endoplasmic reticulum quality control compartment	ISO
endoplasmic reticulum membrane

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

endoplasmic reticulum membrane

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

trans-Golgi network

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

endosome

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle

endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle

endosome

endoplasmic reticulum quality control compartment

Displaying **all 5** entries
GO Term	Evidence Code	PMID
hydrolase activity	IEA
hydrolase activity, acting on glycosyl bonds	IEA
mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	IBA IMP ISO	15294975
calcium ion binding	IEA
metal ion binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity

hydrolase activity, acting on glycosyl bonds

hydrolase activity, hydrolyzing O-glycosyl compounds [inference]

mannosidase activity [inference]

alpha-mannosidase activity [inference]

mannosyl-oligosaccharide mannosidase activity [inference]

mannosyl-oligosaccharide 1,2-alpha-mannosidase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

calcium ion binding

Gene Ontology information from NCBI Gene and UniProt.

Rhea

RHEA:56028

H₂O

β-D-mannose

Enzyme

3.2.1.113

PMID

RHEA:56008

H₂O

β-D-mannose

Enzyme

3.2.1.113

PMID

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0081097	Rafiq syndrome	Alliance of Genome Resources

Ortholog

Displaying entries **31 - 40** of 74 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Pan troglodytes	473099		PANTR45324
Pongo abelii	100432279		PONAB35556
Homo sapiens	11253	HGNC:6823	HUMAN99404
Canis lupus familiaris	480667		CANLF19229
Canis lupus familiaris	119873342		CANLF19229
Vulpes vulpes	112911405		VULVU37737
Ursus americanus	123796320		URSAM31250
Felis catus	111557571		FELCA29307
Felis catus	123381672		FELCA29307
Balaenoptera musculus	118896702		BALMU14186