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purinergic receptor P2X, ligand-gated ion channel, 3

Summary

Gene Symbol

P2rx3

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

228139

PubChem

228139

Alliance of Genome Resources

MGI:1097160

Annotation

Keyword

ATP-binding
Cell membrane
Disulfide bond
Glycoprotein
Ligand-gated ion channel
Receptor
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q3UR32	ATP receptor Purinergic receptor

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 28 in total

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GO Term	Evidence Code	PMID
monoatomic cation transmembrane transport	IEA
behavioral response to pain	IGI IMP	11069181 11069182 15961431
sensory perception of taste	IGI	16322458
protein homotrimerization	ISO ISS
behavioral response to formalin induced pain	ISO

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

neuromuscular synaptic transmission

signal transduction [inference]

cell surface receptor signaling pathway [inference]

purinergic nucleotide receptor signaling pathway

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to ATP

cellular response to organonitrogen compound [inference]

cellular response to ATP

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to ATP

cellular response to oxygen-containing compound [inference]

cellular response to ATP

cellular response to salt [inference]

cellular response to ATP

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport

calcium ion transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport

calcium ion transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization [inference]

protein homotrimerization

protein trimerization [inference]

protein homotrimerization

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization [inference]

protein homotrimerization

protein trimerization [inference]

protein homotrimerization

multicellular organismal process [inference]

system process [inference]

muscle system process [inference]

muscle contraction [inference]

smooth muscle contraction [inference]

phasic smooth muscle contraction [inference]

peristalsis

urinary tract smooth muscle contraction [inference]

urinary bladder smooth muscle contraction

nervous system process [inference]

sensory perception [inference]

sensory perception of chemical stimulus [inference]

sensory perception of taste

behavior [inference]

chemosensory behavior [inference]

behavioral response to chemical pain [inference]

behavioral response to formalin induced pain

behavioral response to pain

behavioral response to chemical pain [inference]

behavioral response to formalin induced pain

response to stimulus [inference]

response to stress [inference]

response to external stimulus [inference]

response to mechanical stimulus

response to abiotic stimulus [inference]

response to temperature stimulus

response to mechanical stimulus

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia

response to endogenous stimulus [inference]

cellular response to endogenous stimulus [inference]

cellular response to organonitrogen compound [inference]

cellular response to ATP

response to chemical [inference]

response to organic substance [inference]

response to carbohydrate

response to organonitrogen compound [inference]

response to purine-containing compound [inference]

response to ATP

cellular response to ATP

cellular response to organonitrogen compound [inference]

cellular response to ATP

response to organic cyclic compound [inference]

response to purine-containing compound [inference]

response to ATP

cellular response to ATP

cellular response to organic cyclic compound [inference]

cellular response to ATP

response to organophosphorus [inference]

response to ATP

cellular response to ATP

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to ATP

cellular response to organonitrogen compound [inference]

cellular response to ATP

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to ATP

cellular response to organonitrogen compound [inference]

cellular response to ATP

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to ATP

cellular response to oxygen-containing compound [inference]

cellular response to ATP

cellular response to salt [inference]

cellular response to ATP

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to purine-containing compound [inference]

response to ATP

cellular response to ATP

cellular response to organonitrogen compound [inference]

cellular response to ATP

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to ATP

response to oxygen-containing compound [inference]

response to carbohydrate

response to ATP

cellular response to ATP

cellular response to oxygen-containing compound [inference]

cellular response to ATP

response to salt [inference]

response to ATP

cellular response to ATP

cellular response to salt [inference]

cellular response to ATP

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to ATP

cellular response to organonitrogen compound [inference]

cellular response to ATP

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to ATP

cellular response to oxygen-containing compound [inference]

cellular response to ATP

cellular response to salt [inference]

cellular response to ATP

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport

monoatomic cation transport

metal ion transport [inference]

calcium ion transport [inference]

calcium ion transmembrane transport

monoatomic cation transmembrane transport

calcium ion transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport

calcium ion transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport

calcium ion transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport

calcium ion transmembrane transport

organic substance transport [inference]

calcium ion transport [inference]

calcium ion transmembrane transport

establishment of localization in cell

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission

regulation of synaptic plasticity

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

neuromuscular synaptic transmission

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

purinergic nucleotide receptor signaling pathway

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission

regulation of synaptic plasticity

regulation of biological quality [inference]

regulation of membrane potential [inference]

action potential [inference]

neuronal action potential

regulation of postsynaptic membrane potential [inference]

excitatory postsynaptic potential

regulation of synaptic plasticity

Displaying entry **11 - 11** of 11 in total

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GO Term	Evidence Code	PMID
axon	IDA	11466438 24378336

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

synaptic membrane [inference]

presynaptic membrane

cell junction [inference]

synapse [inference]

Schaffer collateral - CA1 synapse

neuron to neuron synapse [inference]

hippocampal mossy fiber to CA3 synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

axon

neuron spine [inference]

dendritic spine

cell body [inference]

neuronal cell body

presynapse [inference]

terminal bouton

postsynapse

dendritic spine

Displaying **all 4** entries
GO Term	Evidence Code	PMID
purinergic nucleotide receptor activity	ISO ISS
identical protein binding	ISO
extracellularly ATP-gated monoatomic cation channel activity	IBA IGI ISO ISS TAS	15081800 9300827
ATP binding	ISO ISS

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

monoatomic cation channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

extracellularly ATP-gated monoatomic cation channel activity

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity [inference]

excitatory extracellular ligand-gated monoatomic ion channel activity [inference]

extracellularly ATP-gated monoatomic cation channel activity

ligand-gated monoatomic cation channel activity [inference]

extracellularly ATP-gated monoatomic cation channel activity

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

extracellularly ATP-gated monoatomic cation channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

monoatomic cation channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

extracellularly ATP-gated monoatomic cation channel activity

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity [inference]

excitatory extracellular ligand-gated monoatomic ion channel activity [inference]

extracellularly ATP-gated monoatomic cation channel activity

ligand-gated monoatomic cation channel activity [inference]

extracellularly ATP-gated monoatomic cation channel activity

gated channel activity [inference]

ligand-gated channel activity [inference]

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity [inference]

excitatory extracellular ligand-gated monoatomic ion channel activity [inference]

extracellularly ATP-gated monoatomic cation channel activity

ligand-gated monoatomic cation channel activity [inference]

extracellularly ATP-gated monoatomic cation channel activity

ATP-gated ion channel activity [inference]

extracellularly ATP-gated monoatomic cation channel activity

binding [inference]

protein binding [inference]

identical protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

nucleotide receptor activity [inference]

purinergic nucleotide receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

P2X purinoceptor 3

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
P: Inorganic ion transport and metabolism

Displaying entries **1 - 10** of 12 in total

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Gene Ontology
ATP binding
calcium ion transmembrane transport
cell surface receptor signaling pathway
cell-cell signaling
excitatory postsynaptic potential
extracellularly ATP-gated monoatomic cation channel activity
monoatomic ion channel activity
monoatomic ion transport
nucleotide binding
regulation of biological quality

Displaying **all 3** entries
InterPro
P2X purinoreceptor extracellular domain superfamily
P2X purinoreceptor
P2X3 purinoceptor

Ortholog

Displaying entries **1 - 10** of **101** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	5024		HGNC:8534	HUMAN05992
Danio rerio	58147		ZFIN:ZDB-GENE-000427-3
Rattus norvegicus	81739	10116_1:0015d0	RGD:620253	RATNO28147
Danio rerio	387300		ZFIN:ZDB-GENE-030319-3	DANRE16728
Canis lupus familiaris	448782			CANLF05733
Sus scrofa	503656			PIGXX17223
Bos taurus	530468			BOVIN07674
Macaca mulatta	706503			MACMU09960
Pan troglodytes	742961			PANTR02917
Felis catus	751615			FELCA24382

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements