GlyCosmos Portal

Submissions

dolichol kinase

Summary

Gene Symbol

DOLK

Aliases

DK1
KIAA1094
dolichol kinase 1

Organism

Homo sapiens (human)

External Links

NCBI Gene

22845

HGNC

23406

KEGG Gene ID

hsa:22845

PubChem

22845

Alliance of Genome Resources

HGNC:23406

Annotation

Keyword

Congenital disorder of glycosylation
Disease variant
Endoplasmic reticulum
Kinase
Lipid metabolism
Reference proteome
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q9UPQ8	Transmembrane protein 15
A0A0S2Z597

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
protein N-linked glycosylation	IGI	12213788
dolichyl diphosphate biosynthetic process	TAS
dolichol metabolic process	IGI	12213788
protein mannosylation	IMP	22242004
dolichyl monophosphate biosynthetic process	IDA	12213788 16923818

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

biosynthetic process [inference]

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

dolichyl diphosphate metabolic process [inference]

dolichyl diphosphate biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

dolichyl diphosphate metabolic process [inference]

dolichyl diphosphate biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

dolichyl diphosphate metabolic process [inference]

dolichyl diphosphate biosynthetic process

isoprenoid metabolic process [inference]

polyprenol metabolic process [inference]

dolichol metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

dolichyl diphosphate metabolic process [inference]

dolichyl diphosphate biosynthetic process

isoprenoid metabolic process [inference]

polyprenol metabolic process [inference]

dolichol metabolic process

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

small molecule metabolic process [inference]

alcohol metabolic process [inference]

polyprenol metabolic process [inference]

dolichol metabolic process

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation [inference]

mannosylation [inference]

protein mannosylation

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

dolichyl diphosphate metabolic process [inference]

dolichyl diphosphate biosynthetic process

isoprenoid metabolic process [inference]

polyprenol metabolic process [inference]

dolichol metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

dolichyl diphosphate metabolic process [inference]

dolichyl diphosphate biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

polyprenol metabolic process [inference]

dolichol metabolic process

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

dolichyl diphosphate metabolic process [inference]

dolichyl diphosphate biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

dolichyl diphosphate metabolic process [inference]

dolichyl diphosphate biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

dolichyl diphosphate metabolic process [inference]

dolichyl diphosphate biosynthetic process

isoprenoid metabolic process [inference]

polyprenol metabolic process [inference]

dolichol metabolic process

Displaying **all 3** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum membrane	TAS
endoplasmic reticulum membrane	IDA	16923818
endoplasmic reticulum membrane	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

Displaying **all 5** entries
GO Term	Evidence Code	PMID
dolichol kinase activity	TAS
dolichol kinase activity	IDA	12213788 16923818
dolichol kinase activity	IMP	22242004
dolichol kinase activity	IBA
protein binding	IPI	25416956 26871637 28514442 32296183 33961781

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

dolichol kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

dolichol kinase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Dolichol kinase

Functional Category

C: Energy production and conversion
E: Amino acid transport and metabolism
J: Translation, ribosomal structure and biogenesis

Displaying **all 2** entries
Gene Ontology
diphthine-ammonia ligase activity
protein histidyl modification to diphthamide

KEGG BRITE Database

Orthology

K00902

Name

dolichol kinase [EC:2.7.1.108]

References

12213788

Rhea

RHEA:13133

CTP

H⁺ + CDP

Enzyme

2.7.1.108

PMID

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0080565	congenital disorder of glycosylation Im	Glyco-Disease Genes Database Alliance of Genome Resources

The Human Phenotype Ontology

Displaying entries **1 - 10** of 55 in total

1

2

3

4

5

6

Next ›

Last »
HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000253	Progressive microcephaly
HP:0000407	Sensorineural hearing impairment
HP:0000486	Strabismus
HP:0000505	Visual impairment
HP:0000639	Nystagmus
HP:0000653	Sparse eyelashes
HP:0000729	Autistic behavior
HP:0000817	Reduced eye contact
HP:0000958	Dry skin

Displaying **all 3** entries
Disease ID	Disease Name
ORPHA:154	dilated cardiomyopathy 1KK obsolete familial isolated dilated cardiomyopathy
ORPHA:91131	DK1-congenital disorder of glycosylation
OMIM:610768	DK1-congenital disorder of glycosylation

PubChem Disease

GHR Health Conditions

DOLK-congenital disorder of glycosylation

MedGen Diseases

DK1-congenital disorder of glycosylation

OMIM Phenotypes

CONGENITAL DISORDER OF GLYCOSYLATION, TYPE Im; CDG1M

KEGG Diseases

Congenital disorders of glycosylation type I

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP006686
Gene Name: dolichol kinase

Ortholog

Displaying entries **1 - 10** of 83 in total

1

2

3

4

5

…

Next ›

Last »
Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	22845	Xenbase:XB-GENE-966505
Xenopus tropicalis	36856	Xenbase:XB-GENE-966505
Mus musculus	227697		MOUSE32989
Rattus norvegicus	311847		RATNO28868
Bos taurus	526844		BOVIN03265
Macaca mulatta	717045		MACMU11971
Danio rerio	799960		DANRE20728
Monodelphis domestica	100013804		MONDO03867
Equus caballus	100070129		HORSE23659
Ornithorhynchus anatinus	100088250		ORNAN20145

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements