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dolichol kinase

Summary

Gene Symbol

DOLK

Aliases

DK1
KIAA1094
dolichol kinase 1

Organism

Homo sapiens (human)

External Links

NCBI Gene

22845

HGNC

23406

KEGG Gene ID

hsa:22845

PubChem

22845

Alliance of Genome Resources

HGNC:23406

Annotation

Keyword

Congenital disorder of glycosylation
Disease variant
Endoplasmic reticulum
Kinase
Lipid metabolism
Reference proteome
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q9UPQ8	Transmembrane protein 15
A0A0S2Z597

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
phosphorylation	IEA
protein mannosylation	IMP	22242004
dolichyl monophosphate biosynthetic process	IBA IDA IMP	12213788 16923818 22242004
dolichyl diphosphate biosynthetic process

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein mannosylation

biosynthetic process [inference]

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

dolichyl diphosphate metabolic process [inference]

dolichyl diphosphate biosynthetic process

phosphorylation

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

dolichyl diphosphate metabolic process [inference]

dolichyl diphosphate biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

dolichyl diphosphate metabolic process [inference]

dolichyl diphosphate biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

dolichyl diphosphate metabolic process [inference]

dolichyl diphosphate biosynthetic process

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein mannosylation

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein mannosylation

mannosylation [inference]

protein mannosylation

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

dolichyl diphosphate metabolic process [inference]

dolichyl diphosphate biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

dolichyl diphosphate metabolic process [inference]

dolichyl diphosphate biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein mannosylation

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation [inference]

protein mannosylation

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein mannosylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein mannosylation

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

dolichyl diphosphate metabolic process [inference]

dolichyl diphosphate biosynthetic process

phosphorylation

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

dolichyl diphosphate metabolic process [inference]

dolichyl diphosphate biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

dolichyl diphosphate metabolic process [inference]

dolichyl diphosphate biosynthetic process

Displaying 1 entry
GO Term	Evidence Code	PMID
endoplasmic reticulum membrane	IBA IDA TAS	16923818

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

Displaying **all 2** entries
GO Term	Evidence Code	PMID
protein binding	IPI	25416956 26871637 28514442 32296183 33961781
dolichol kinase activity	IBA IDA IMP TAS	12213788 16923818 22242004

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

dolichol kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

dolichol kinase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Dolichol kinase

Functional Category

I: Lipid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 3** entries
Gene Ontology
dolichol kinase activity
dolichyl monophosphate biosynthetic process
transferase activity

Displaying 1 entry
InterPro
Polyprenol kinase family

KEGG BRITE Database

Orthology

K00902

Name

dolichol kinase [EC:2.7.1.108]

References

12213788

Rhea

RHEA:13133

CTP

H⁺ + CDP

Enzyme

2.7.1.108

PMID

Disease

The Human Phenotype Ontology

Displaying entries **1 - 10** of 55 in total

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000253	Progressive microcephaly
HP:0000407	Sensorineural hearing impairment
HP:0000486	Strabismus
HP:0000505	Visual impairment
HP:0000639	Nystagmus
HP:0000653	Sparse eyelashes
HP:0000729	Autistic behavior
HP:0000817	Reduced eye contact
HP:0000958	Dry skin

Displaying **all 3** entries
Disease ID	Disease Name
ORPHA:154	dilated cardiomyopathy 1KK obsolete familial isolated dilated cardiomyopathy
OMIM:610768	DK1-congenital disorder of glycosylation
ORPHA:91131	DK1-congenital disorder of glycosylation

PubChem Disease

GHR Health Conditions

DOLK-congenital disorder of glycosylation

MedGen Diseases

DK1-congenital disorder of glycosylation

OMIM Phenotypes

CONGENITAL DISORDER OF GLYCOSYLATION, TYPE Im; CDG1M

KEGG Diseases

Congenital disorders of glycosylation type I

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP006686
Gene Name: dolichol kinase

Ortholog

Displaying entries **11 - 20** of 89 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Equus caballus	100070129			HORSE23659
Ornithorhynchus anatinus	100088250			ORNAN20145
Equus caballus	100146151			HORSE23659
Sus scrofa	100152320			PIGXX16303
Taeniopygia guttata	100217598			TAEGU06484
Pongo abelii	100294666	9601_0:0028ef		PONAB36376
Oryctolagus cuniculus	100344382			RABIT18281
Xenopus tropicalis	100380159		Xenbase:XB-GENE-966505
Ailuropoda melanoleuca	100463796			AILME16872
Meleagris gallopavo	100549792			MELGA05221

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GlyComb

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UniCarb-DR

LM-GlycoRepo

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Other Information

Tools

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Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements