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microtubule associated protein RP/EB family member 1

Summary

Gene Symbol

MAPRE1

Organism

Homo sapiens (human)

External Links

NCBI Gene

22919

PubChem

22919

Alliance of Genome Resources

HGNC:6890

Annotation

Keyword

3D-structure
Acetylation
Cytoskeleton
Direct protein sequencing
Golgi apparatus
Microtubule
Mitosis
Phosphoprotein
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q15691	APC-binding protein EB1 End-binding protein 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **11 - 15** of 16 in total

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GO Term	Evidence Code	PMID
protein localization to microtubule	IBA IDA	19632184 21820309
non-motile cilium assembly	IEA
establishment of mitotic spindle orientation	IDA	34608293
attachment of mitotic spindle microtubules to kinetochore	IDA IPI	23001180 36592928
protein localization	TAS	26323690

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process [inference]

microtubule cytoskeleton organization [inference]

microtubule bundle formation

spindle organization [inference]

spindle assembly

microtubule polymerization or depolymerization [inference]

microtubule polymerization

establishment of spindle localization [inference]

establishment of mitotic spindle localization [inference]

establishment of mitotic spindle orientation

establishment of spindle orientation [inference]

establishment of mitotic spindle orientation

microtubule cytoskeleton organization involved in mitosis [inference]

establishment of mitotic spindle localization [inference]

establishment of mitotic spindle orientation

cell cycle process [inference]

spindle organization [inference]

spindle assembly

attachment of spindle microtubules to kinetochore [inference]

attachment of mitotic spindle microtubules to kinetochore

spindle localization [inference]

establishment of spindle localization [inference]

establishment of mitotic spindle localization [inference]

establishment of mitotic spindle orientation

establishment of spindle orientation [inference]

establishment of mitotic spindle orientation

mitotic cell cycle process [inference]

attachment of mitotic spindle microtubules to kinetochore

microtubule cytoskeleton organization involved in mitosis [inference]

establishment of mitotic spindle localization [inference]

establishment of mitotic spindle orientation

cell motility [inference]

cell migration

cell division

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization

protein localization to organelle [inference]

protein localization to cytoskeleton [inference]

protein localization to microtubule cytoskeleton [inference]

protein localization to microtubule

protein localization to spindle microtubule [inference]

protein localization to astral microtubule

protein localization to cytoplasmic microtubule [inference]

protein localization to astral microtubule

protein localization to mitotic spindle

protein localization to microtubule organizing center [inference]

protein localization to centrosome

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

microtubule cytoskeleton organization [inference]

microtubule bundle formation

spindle organization [inference]

spindle assembly

microtubule polymerization or depolymerization [inference]

microtubule polymerization

establishment of spindle localization [inference]

establishment of mitotic spindle localization [inference]

establishment of mitotic spindle orientation

establishment of spindle orientation [inference]

establishment of mitotic spindle orientation

microtubule cytoskeleton organization involved in mitosis [inference]

establishment of mitotic spindle localization [inference]

establishment of mitotic spindle orientation

cilium organization [inference]

cilium assembly [inference]

non-motile cilium assembly

organelle assembly [inference]

cilium assembly [inference]

non-motile cilium assembly

non-membrane-bounded organelle assembly [inference]

spindle assembly

cellular component assembly [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

cilium assembly [inference]

non-motile cilium assembly

protein-containing complex assembly [inference]

protein polymerization [inference]

microtubule polymerization

organelle assembly [inference]

cilium assembly [inference]

non-motile cilium assembly

non-membrane-bounded organelle assembly [inference]

spindle assembly

cell projection organization [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

cilium assembly [inference]

non-motile cilium assembly

plasma membrane bounded cell projection organization [inference]

cilium organization [inference]

cilium assembly [inference]

non-motile cilium assembly

plasma membrane bounded cell projection assembly [inference]

cilium assembly [inference]

non-motile cilium assembly

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein polymerization [inference]

microtubule polymerization

supramolecular fiber organization [inference]

microtubule polymerization

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization

protein localization to organelle [inference]

protein localization to cytoskeleton [inference]

protein localization to microtubule cytoskeleton [inference]

protein localization to microtubule

protein localization to spindle microtubule [inference]

protein localization to astral microtubule

protein localization to cytoplasmic microtubule [inference]

protein localization to astral microtubule

protein localization to mitotic spindle

protein localization to microtubule organizing center [inference]

protein localization to centrosome

establishment of localization [inference]

establishment of localization in cell [inference]

establishment of spindle localization [inference]

establishment of mitotic spindle localization [inference]

establishment of mitotic spindle orientation

establishment of spindle orientation [inference]

establishment of mitotic spindle orientation

establishment of organelle localization [inference]

establishment of spindle localization [inference]

establishment of mitotic spindle localization [inference]

establishment of mitotic spindle orientation

establishment of spindle orientation [inference]

establishment of mitotic spindle orientation

organelle localization [inference]

spindle localization [inference]

establishment of spindle localization [inference]

establishment of mitotic spindle localization [inference]

establishment of mitotic spindle orientation

establishment of spindle orientation [inference]

establishment of mitotic spindle orientation

establishment of organelle localization [inference]

establishment of spindle localization [inference]

establishment of mitotic spindle localization [inference]

establishment of mitotic spindle orientation

establishment of spindle orientation [inference]

establishment of mitotic spindle orientation

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization

protein localization to organelle [inference]

protein localization to cytoskeleton [inference]

protein localization to microtubule cytoskeleton [inference]

protein localization to microtubule

protein localization to spindle microtubule [inference]

protein localization to astral microtubule

protein localization to cytoplasmic microtubule [inference]

protein localization to astral microtubule

protein localization to mitotic spindle

protein localization to microtubule organizing center [inference]

protein localization to centrosome

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of microtubule polymerization

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule polymerization

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of microtubule polymerization

positive regulation of supramolecular fiber organization [inference]

positive regulation of microtubule polymerization

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of microtubule polymerization or depolymerization [inference]

negative regulation of microtubule polymerization

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization [inference]

negative regulation of microtubule polymerization

negative regulation of supramolecular fiber organization [inference]

negative regulation of microtubule polymerization

regulation of cellular process [inference]

regulation of microtubule-based process [inference]

regulation of microtubule cytoskeleton organization [inference]

regulation of microtubule polymerization or depolymerization

negative regulation of microtubule polymerization or depolymerization [inference]

negative regulation of microtubule polymerization

positive regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule polymerization

regulation of microtubule polymerization [inference]

regulation of cellular component biogenesis [inference]

regulation of protein-containing complex assembly [inference]

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization [inference]

negative regulation of microtubule polymerization

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of microtubule polymerization

regulation of protein polymerization [inference]

regulation of microtubule polymerization [inference]

negative regulation of protein polymerization [inference]

negative regulation of microtubule polymerization

positive regulation of protein polymerization [inference]

positive regulation of microtubule polymerization

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of microtubule polymerization

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of microtubule polymerization

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule polymerization

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of microtubule polymerization

positive regulation of supramolecular fiber organization [inference]

positive regulation of microtubule polymerization

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of microtubule polymerization or depolymerization [inference]

negative regulation of microtubule polymerization

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization [inference]

negative regulation of microtubule polymerization

negative regulation of supramolecular fiber organization [inference]

negative regulation of microtubule polymerization

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule polymerization

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of microtubule polymerization or depolymerization [inference]

negative regulation of microtubule polymerization

regulation of cytoskeleton organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of microtubule polymerization or depolymerization [inference]

negative regulation of microtubule polymerization

positive regulation of cytoskeleton organization [inference]

positive regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule polymerization

regulation of microtubule cytoskeleton organization [inference]

regulation of microtubule polymerization or depolymerization

negative regulation of microtubule polymerization or depolymerization [inference]

negative regulation of microtubule polymerization

positive regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule polymerization

regulation of microtubule polymerization [inference]

regulation of protein-containing complex assembly [inference]

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization [inference]

negative regulation of microtubule polymerization

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of microtubule polymerization

regulation of protein polymerization [inference]

regulation of microtubule polymerization [inference]

negative regulation of protein polymerization [inference]

negative regulation of microtubule polymerization

positive regulation of protein polymerization [inference]

positive regulation of microtubule polymerization

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of microtubule polymerization or depolymerization [inference]

negative regulation of microtubule polymerization

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization [inference]

negative regulation of microtubule polymerization

negative regulation of supramolecular fiber organization [inference]

negative regulation of microtubule polymerization

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule polymerization

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of microtubule polymerization

positive regulation of supramolecular fiber organization [inference]

positive regulation of microtubule polymerization

regulation of supramolecular fiber organization [inference]

regulation of microtubule polymerization [inference]

negative regulation of supramolecular fiber organization [inference]

negative regulation of microtubule polymerization

positive regulation of supramolecular fiber organization [inference]

positive regulation of microtubule polymerization

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
spindle	IDA	11943150
cell projection membrane	IEA
mitotic spindle microtubule	IDA	27225956
centrosome	IDA	21399614
cytosol	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

spindle pole [inference]

mitotic spindle pole

microtubule organizing center

cytosol

membrane [inference]

plasma membrane region [inference]

cell projection membrane

cell junction [inference]

anchoring junction [inference]

cell-substrate junction [inference]

focal adhesion

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

spindle

cytoskeleton [inference]

cortical cytoskeleton [inference]

cortical microtubule cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular non-membrane-bounded organelle [inference]

spindle

cytoskeleton [inference]

cortical cytoskeleton [inference]

cortical microtubule cytoskeleton

spindle midzone

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

microtubule

spindle microtubule [inference]

mitotic spindle microtubule

cytoplasmic microtubule

microtubule end [inference]

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
protein kinase binding	IPI	26323690
RNA binding	HDA	22681889
cadherin binding	HDA	25468996
protein binding	IPI	10226031 10644998 10773885 11943150 15631994 16455083 17563362 17828277 18477699 19543227 19553473 19632184 21303978 21646404 21820309 23574715 23874158 24997520 25225338 25416956 26242911 26485573 26496610 26638075 27107012 27173435 28514442 29162697 29997244 31515488 32296183 32814053 33961781 35271311 36592928
identical protein binding	IPI	25416956 27107012 31515488 32296183

GO Hierarchy

molecular function

binding [inference]

protein binding

cytoskeletal protein binding [inference]

tubulin binding [inference]

microtubule binding [inference]

microtubule plus-end binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding

identical protein binding

cell adhesion molecule binding [inference]

cadherin binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding

Gene Ontology information from NCBI Gene and UniProt.

Ortholog

Displaying entries **11 - 20** of 73 in total

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Species	Gene ID	Orthologous MAtrix
Monodelphis domestica	100010572	MONDO01581
Ornithorhynchus anatinus	100090477	ORNAN14017
Pongo abelii	100173206	PONAB20222
Ciona intestinalis	100181072	CIOIN09694
Taeniopygia guttata	100220958	TAEGU12438
Oryctolagus cuniculus	100349568	RABIT10084
Callithrix jacchus	100412343	CALJA33985
Ailuropoda melanoleuca	100466478	AILME13727
Nomascus leucogenys	100592140	NOMLE06580
Loxodonta africana	100661349	LOXAF13055

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