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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
sirtuin 2
Summary
- Gene Symbol
-
- SIRT2
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Acetylation
- Alternative splicing
- Autophagy
- Cell membrane
- Cell projection
- Chromosome
- Cytoskeleton
- Differentiation
- Innate immunity
- Meiosis
- Metal-binding
- Microtubule
- Mitosis
- NAD
- Neurodegeneration
- Neurogenesis
- Nucleus
- Phosphoprotein
- Proteomics identification
- Reference proteome
- Transcription regulation
- Transferase
- Ubl conjugation
- Zinc
- Proteins
| UniProt | Protein Name |
|---|---|
| A0A0A0MRF5 |
|
| Q8IXJ6 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| proteasome-mediated ubiquitin-dependent protein catabolic process | ||
| autophagy | ||
| positive regulation of cell division | ||
| cellular lipid catabolic process | ||
| subtelomeric heterochromatin formation |
GO Hierarchy
- regulation of myelination
biological process
metabolic process [inference]
cellular process [inference]
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
negative regulation of metabolic process [inference]
positive regulation of metabolic process [inference]
regulation of catabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
negative regulation of cellular metabolic process [inference]
positive regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
positive regulation of nitrogen compound metabolic process [inference]
regulation of protein metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of macromolecule biosynthetic process [inference]
positive regulation of macromolecule metabolic process [inference]
regulation of protein metabolic process [inference]
regulation of RNA metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of lipid metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
regulation of protein metabolic process [inference]
positive regulation of biological process [inference]
positive regulation of metabolic process [inference]
positive regulation of cellular process [inference]
negative regulation of biological process [inference]
negative regulation of metabolic process [inference]
negative regulation of cellular process [inference]
negative regulation of developmental process [inference]
regulation of developmental process [inference]
regulation of cellular process [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
negative regulation of cellular metabolic process [inference]
positive regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of cell differentiation [inference]
positive regulation of cellular process [inference]
negative regulation of cellular process [inference]
regulation of cellular component organization [inference]
regulation of multicellular organismal process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| heterochromatin | ||
| chromatin silencing complex | ||
| microtubule | ||
| paranode region of axon | ||
| spindle |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| histone deacetylase binding | ||
| protein binding | ||
| zinc ion binding | ||
| histone acetyltransferase binding | ||
| DNA-binding transcription factor binding |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- DeAcetylase
- Functional Category
-
- O: Posttranslational modification, protein turnover, chaperones
- Q: Secondary metabolites biosynthesis, transport and catabolism
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| NAD+ binding |
| NAD-dependent histone deacetylase activity |
| metal ion binding |
| transferase activity |
| InterPro |
|---|
| DHS-like NAD/FAD-binding domain superfamily |
| Sirtuin family, catalytic core domain |
| Sirtuin family |
| Sirtuin, catalytic core small domain superfamily |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Rhea
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0080208 | metabolic dysfunction-associated steatotic liver disease | |
| DOID:3070 | high grade glioma | |
| DOID:3669 | intermittent claudication | |
| DOID:9975 | cocaine dependence |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 42414 | FB:FBgn0038788 | |||
| 64383 | MGI:1927664 | MOUSE53362 | ||
| 114556 | RGD:621481 | |||
| 322309 | ZFIN:ZDB-GENE-030131-1028 | DANRE08771 | ||
| 361532 | RATNO17242 | |||
| 456013 | 9598_0:004cb4 | |||
| 495688 | Xenbase:XB-GENE-987378 | |||
| 856092 | SGD:S000005936 | |||
| 100125964 | PIGXX27798 | |||
| 100172430 | 9601_0:004b20 | PONAB14186 |
