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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
sirtuin 2
Summary
- Gene Symbol
-
- SIRT2
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Acetylation
- Alternative splicing
- Autophagy
- Cell membrane
- Cell projection
- Chromosome
- Cytoskeleton
- Differentiation
- Innate immunity
- Meiosis
- Metal-binding
- Microtubule
- Mitosis
- NAD
- Neurodegeneration
- Neurogenesis
- Nucleus
- Phosphoprotein
- Proteomics identification
- Reference proteome
- Transcription regulation
- Transferase
- Ubl conjugation
- Zinc
- Proteins
| UniProt | Protein Name |
|---|---|
| A0A0A0MRF5 |
|
| Q8IXJ6 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| subtelomeric heterochromatin formation | ||
| positive regulation of DNA binding | ||
| proteasome-mediated ubiquitin-dependent protein catabolic process | ||
| regulation of phosphorylation | ||
| epigenetic regulation of gene expression |
GO Hierarchy
- regulation of myelination
biological process
metabolic process [inference]
cellular process [inference]
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
negative regulation of metabolic process [inference]
positive regulation of metabolic process [inference]
regulation of catabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
negative regulation of cellular metabolic process [inference]
positive regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
positive regulation of nitrogen compound metabolic process [inference]
regulation of protein metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of macromolecule biosynthetic process [inference]
positive regulation of macromolecule metabolic process [inference]
regulation of protein metabolic process [inference]
regulation of RNA metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of lipid metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
regulation of protein metabolic process [inference]
positive regulation of biological process [inference]
positive regulation of metabolic process [inference]
positive regulation of cellular process [inference]
negative regulation of biological process [inference]
negative regulation of metabolic process [inference]
negative regulation of cellular process [inference]
negative regulation of developmental process [inference]
regulation of developmental process [inference]
regulation of cellular process [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
negative regulation of cellular metabolic process [inference]
positive regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of cell differentiation [inference]
positive regulation of cellular process [inference]
negative regulation of cellular process [inference]
regulation of cellular component organization [inference]
regulation of multicellular organismal process [inference]
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| NAD+ ADP-ribosyltransferase activity | ||
| transcription factor binding | ||
| NAD-dependent histone deacetylase activity | ||
| zinc ion binding | ||
| chromatin binding |
GO Hierarchy
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Rhea
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:9970 | obesity | |
| DOID:0040085 | bacterial sepsis | |
| DOID:0050387 | nonpapillary renal cell carcinoma | |
| DOID:0050635 | alternating hemiplegia of childhood | |
| DOID:0050646 | distal arthrogryposis | |
| DOID:0050865 | tongue squamous cell carcinoma | |
| DOID:0060061 | primary cutaneous T-cell non-Hodgkin lymphoma | |
| DOID:0060891 | Parkinson's disease 19A | |
| DOID:0060895 | Parkinson's disease 4 | |
| DOID:0060896 | Parkinson's disease 23 |
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 42414 | FB:FBgn0038788 | ||
| 100185251 | CIOIN12353 | ||
| 322309 | ZFIN:ZDB-GENE-030131-1028 | DANRE08771 | |
| 103038996 | ASTMX16188 | ||
| 128628623 | ICTPU15164 | ||
| 113584652 | ELEEL34062 | ||
| 115163165 | SALTR98772 | ||
| 115561108 | GADMO18756 | ||
| 100690476 | ORENI17756 | ||
| 115570409 | SPAAU16743 |
