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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
sirtuin 2
Summary
- Gene Symbol
-
- SIRT2
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Acetylation
- Alternative splicing
- Autophagy
- Cell membrane
- Cell projection
- Chromosome
- Cytoskeleton
- Differentiation
- Innate immunity
- Meiosis
- Metal-binding
- Microtubule
- Mitosis
- NAD
- Neurodegeneration
- Neurogenesis
- Nucleus
- Phosphoprotein
- Proteomics identification
- Reference proteome
- Transcription regulation
- Transferase
- Ubl conjugation
- Zinc
- Proteins
| UniProt | Protein Name |
|---|---|
| A0A0A0MRF5 |
|
| Q8IXJ6 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| subtelomeric heterochromatin formation | ||
| positive regulation of DNA binding | ||
| proteasome-mediated ubiquitin-dependent protein catabolic process | ||
| regulation of phosphorylation | ||
| epigenetic regulation of gene expression |
GO Hierarchy
- regulation of myelination
biological process
metabolic process [inference]
cellular process [inference]
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
negative regulation of metabolic process [inference]
positive regulation of metabolic process [inference]
regulation of catabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
negative regulation of cellular metabolic process [inference]
positive regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
positive regulation of nitrogen compound metabolic process [inference]
regulation of protein metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of macromolecule biosynthetic process [inference]
positive regulation of macromolecule metabolic process [inference]
regulation of protein metabolic process [inference]
regulation of RNA metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of lipid metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
regulation of protein metabolic process [inference]
positive regulation of biological process [inference]
positive regulation of metabolic process [inference]
positive regulation of cellular process [inference]
negative regulation of biological process [inference]
negative regulation of metabolic process [inference]
negative regulation of cellular process [inference]
negative regulation of developmental process [inference]
regulation of developmental process [inference]
regulation of cellular process [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
negative regulation of cellular metabolic process [inference]
positive regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of cell differentiation [inference]
positive regulation of cellular process [inference]
negative regulation of cellular process [inference]
regulation of cellular component organization [inference]
regulation of multicellular organismal process [inference]
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| ubiquitin binding | ||
| NAD-dependent protein deacetylase activity | ||
| NAD+-protein ADP-ribosyltransferase activity |
|
|
| NAD-dependent protein demyristoylase activity | ||
| NAD-dependent protein depalmitoylase activity |
GO Hierarchy
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Rhea
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:318 | progressive muscular atrophy | |
| DOID:3247 | rhabdomyosarcoma | |
| DOID:331 | central nervous system disease | |
| DOID:332 | amyotrophic lateral sclerosis | |
| DOID:3324 | mood disorder | |
| DOID:3393 | coronary artery disease | |
| DOID:3429 | inclusion body myositis | |
| DOID:3459 | breast carcinoma | |
| DOID:3523 | brain stem infarction | |
| DOID:3525 | middle cerebral artery infarction |
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 856092 | SGD:S000005936 | ||
| 103750724 | NANGA12068 | ||
| 116452449 | CORMO05329 | ||
| 103276939 | CARSF16553 | ||
| 115603345 | STRHB06826 |
