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SH3 and multiple ankyrin repeat domains 2

Summary

Gene Symbol

SHANK2

Organism

Homo sapiens (human)

External Links

NCBI Gene

22941

PubChem

22941

Alliance of Genome Resources

HGNC:14295

Annotation

Keyword

3D-structure
ANK repeat
Alternative splicing
Autism
Cell membrane
Cell projection
Cytoplasm
Glycoprotein
Phosphoprotein
Proteomics identification
Reference proteome
Repeat
SH3 domain
SH3-binding
Synapse

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q9UPX8	Cortactin-binding protein 1 Proline-rich synapse-associated protein 1
A6NHU9
A0A590UJ45

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
positive regulation of cell population proliferation	IMP	32661924
negative regulation of hippo signaling	IMP	32661924
synapse assembly	ISS	22699620
adult behavior	IMP	20473310
response to xenobiotic stimulus	IEA

GO Hierarchy

biological process

cellular process [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

postsynaptic specialization organization [inference]

postsynaptic density organization [inference]

maintenance of postsynaptic specialization structure [inference]

maintenance of postsynaptic density structure

cellular component assembly [inference]

cell junction assembly [inference]

synapse assembly

cell junction organization [inference]

cell junction assembly [inference]

synapse assembly

cell junction maintenance [inference]

maintenance of synapse structure [inference]

maintenance of postsynaptic specialization structure [inference]

maintenance of postsynaptic density structure

synapse organization [inference]

synapse assembly

maintenance of synapse structure [inference]

maintenance of postsynaptic specialization structure [inference]

maintenance of postsynaptic density structure

cellular component maintenance [inference]

cell junction maintenance [inference]

maintenance of synapse structure [inference]

maintenance of postsynaptic specialization structure [inference]

maintenance of postsynaptic density structure

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory [inference]

learning

associative learning

behavior [inference]

learning or memory [inference]

learning

associative learning

locomotory behavior [inference]

adult locomotory behavior

adult behavior

adult locomotory behavior

response to stimulus [inference]

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to nutrient

response to chemical [inference]

biological process involved in intraspecies interaction between organisms [inference]

social behavior

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of hippo signaling

regulation of intracellular signal transduction [inference]

regulation of hippo signaling [inference]

negative regulation of hippo signaling

negative regulation of intracellular signal transduction [inference]

negative regulation of hippo signaling

positive regulation of signaling [inference]

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of hippo signaling

negative regulation of synaptic transmission [inference]

long-term synaptic depression

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity [inference]

negative regulation of synaptic transmission [inference]

long-term synaptic depression

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of cell communication [inference]

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of hippo signaling

negative regulation of synaptic transmission [inference]

long-term synaptic depression

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of hippo signaling

negative regulation of synaptic transmission [inference]

long-term synaptic depression

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of hippo signaling

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of hippo signaling

regulation of intracellular signal transduction [inference]

regulation of hippo signaling [inference]

negative regulation of hippo signaling

negative regulation of intracellular signal transduction [inference]

negative regulation of hippo signaling

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of hippo signaling

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of hippo signaling

regulation of intracellular signal transduction [inference]

regulation of hippo signaling [inference]

negative regulation of hippo signaling

negative regulation of intracellular signal transduction [inference]

negative regulation of hippo signaling

positive regulation of cell communication [inference]

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of hippo signaling

negative regulation of synaptic transmission [inference]

long-term synaptic depression

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity [inference]

negative regulation of synaptic transmission [inference]

long-term synaptic depression

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of cell communication [inference]

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of hippo signaling

negative regulation of synaptic transmission [inference]

long-term synaptic depression

regulation of cellular component organization [inference]

regulation of synapse organization [inference]

regulation of postsynapse organization

regulation of biological quality [inference]

regulation of synaptic plasticity [inference]

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	PMID
postsynaptic membrane	IBA ISS
postsynaptic density	IBA ISS
apical plasma membrane	ISS
cellular_component	ND
neuronal cell body	ISS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

ciliary membrane

plasma membrane region [inference]

apical plasma membrane

cell projection membrane [inference]

synaptic membrane [inference]

postsynaptic membrane

cell junction [inference]

synapse [inference]

glutamatergic synapse

neuron to neuron synapse [inference]

hippocampal mossy fiber to CA3 synapse

site of polarized growth [inference]

growth cone

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

neuron spine [inference]

dendritic spine

organelle [inference]

postsynaptic specialization [inference]

postsynaptic density

cell body [inference]

neuronal cell body

presynaptic active zone

postsynapse [inference]

dendritic spine

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

intermediate filament [inference]

neurofilament

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IPI	11583995 17474147 32296183 32661924
ionotropic glutamate receptor binding	IBA ISS
SH3 domain binding	IEA
structural constituent of postsynaptic density	IEA
synaptic receptor adaptor activity	IBA NAS	10506216

GO Hierarchy

molecular function

structural molecule activity [inference]

structural constituent of synapse [inference]

structural constituent of postsynapse [inference]

structural constituent of postsynaptic specialization [inference]

structural constituent of postsynaptic density

binding [inference]

protein binding

signaling receptor binding [inference]

glutamate receptor binding [inference]

ionotropic glutamate receptor binding

protein domain specific binding [inference]

SH3 domain binding

molecular adaptor activity [inference]

protein-macromolecule adaptor activity [inference]

signaling adaptor activity [inference]

signaling receptor complex adaptor activity [inference]

synaptic receptor adaptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Ankyrin repeat

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
ionotropic glutamate receptor binding
synaptic receptor adaptor activity

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0060041	autism spectrum disorder	Alliance of Genome Resources
DOID:12849	autistic disorder	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 64 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	50225		FB:FBgn0040752
Rattus norvegicus	171093		RGD:628772	RATNO16637
Caenorhabditis elegans	174739		WB:WBGene00006444
Mus musculus	210274		MGI:2671987	MOUSE51194
Pan troglodytes	466694	9598_0:00317a		PANTR03682
Danio rerio	567595		ZFIN:ZDB-GENE-061207-58
Macaca mulatta	708192			MACMU11074
Xenopus laevis	734458		Xenbase:XB-GENE-984539
Equus caballus	100061705			HORSE05901
Ornithorhynchus anatinus	100075922			ORNAN18792