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nardilysin convertase

Summary

Gene Symbol

Nrdc

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

230598

PubChem

230598

Alliance of Genome Resources

MGI:1201386

Annotation

Keyword

Cell projection
Metal-binding
Metalloprotease
Mitochondrion
Phosphoprotein
Proteomics identification
Reference proteome
Signal
Zinc

Proteins

Displaying **all 3** entries
UniProt	Protein Name
A2A9Q2
A6PWC3
Q8BHG1	N-arginine dibasic convertase Nardilysin convertase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
positive regulation of myelination	IMP	19935654
proteolysis	IEA
negative regulation of cold-induced thermogenesis	IMP	24492630
regulation of endopeptidase activity	ISO
positive regulation of axonogenesis	IMP	19935654

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of cold-induced thermogenesis

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of membrane protein ectodomain proteolysis

positive regulation of protein catabolic process [inference]

positive regulation of membrane protein ectodomain proteolysis

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of membrane protein ectodomain proteolysis

positive regulation of proteolysis [inference]

positive regulation of membrane protein ectodomain proteolysis

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of membrane protein ectodomain proteolysis

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of membrane protein ectodomain proteolysis

positive regulation of proteolysis [inference]

positive regulation of membrane protein ectodomain proteolysis

regulation of catabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of membrane protein ectodomain proteolysis

positive regulation of protein catabolic process [inference]

positive regulation of membrane protein ectodomain proteolysis

regulation of cellular catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of membrane protein ectodomain proteolysis

regulation of membrane protein ectodomain proteolysis [inference]

positive regulation of membrane protein ectodomain proteolysis

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of membrane protein ectodomain proteolysis

regulation of membrane protein ectodomain proteolysis [inference]

positive regulation of membrane protein ectodomain proteolysis

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of membrane protein ectodomain proteolysis

regulation of cellular catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of membrane protein ectodomain proteolysis

regulation of membrane protein ectodomain proteolysis [inference]

positive regulation of membrane protein ectodomain proteolysis

regulation of nitrogen compound metabolic process [inference]

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of membrane protein ectodomain proteolysis

positive regulation of proteolysis [inference]

positive regulation of membrane protein ectodomain proteolysis

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

positive regulation of proteolysis [inference]

positive regulation of membrane protein ectodomain proteolysis

regulation of membrane protein ectodomain proteolysis [inference]

positive regulation of membrane protein ectodomain proteolysis

regulation of peptidase activity [inference]

regulation of endopeptidase activity

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of membrane protein ectodomain proteolysis

regulation of membrane protein ectodomain proteolysis [inference]

positive regulation of membrane protein ectodomain proteolysis

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of membrane protein ectodomain proteolysis

positive regulation of proteolysis [inference]

positive regulation of membrane protein ectodomain proteolysis

regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of membrane protein ectodomain proteolysis

positive regulation of proteolysis [inference]

positive regulation of membrane protein ectodomain proteolysis

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

positive regulation of proteolysis [inference]

positive regulation of membrane protein ectodomain proteolysis

regulation of membrane protein ectodomain proteolysis [inference]

positive regulation of membrane protein ectodomain proteolysis

regulation of peptidase activity [inference]

regulation of endopeptidase activity

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of membrane protein ectodomain proteolysis

regulation of membrane protein ectodomain proteolysis [inference]

positive regulation of membrane protein ectodomain proteolysis

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of membrane protein ectodomain proteolysis

positive regulation of proteolysis [inference]

positive regulation of membrane protein ectodomain proteolysis

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

positive regulation of proteolysis [inference]

positive regulation of membrane protein ectodomain proteolysis

regulation of membrane protein ectodomain proteolysis [inference]

positive regulation of membrane protein ectodomain proteolysis

regulation of peptidase activity [inference]

regulation of endopeptidase activity

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of membrane protein ectodomain proteolysis

regulation of membrane protein ectodomain proteolysis [inference]

positive regulation of membrane protein ectodomain proteolysis

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of membrane protein ectodomain proteolysis

positive regulation of proteolysis [inference]

positive regulation of membrane protein ectodomain proteolysis

regulation of cold-induced thermogenesis [inference]

negative regulation of cold-induced thermogenesis

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of membrane protein ectodomain proteolysis

positive regulation of protein catabolic process [inference]

positive regulation of membrane protein ectodomain proteolysis

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of membrane protein ectodomain proteolysis

positive regulation of proteolysis [inference]

positive regulation of membrane protein ectodomain proteolysis

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of membrane protein ectodomain proteolysis

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of membrane protein ectodomain proteolysis

positive regulation of proteolysis [inference]

positive regulation of membrane protein ectodomain proteolysis

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of membrane protein ectodomain proteolysis

positive regulation of myelination

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of axonogenesis

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system process [inference]

positive regulation of myelination

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of cold-induced thermogenesis

negative regulation of multicellular organismal process [inference]

negative regulation of cold-induced thermogenesis

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of axonogenesis [inference]

positive regulation of axonogenesis

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of myelination [inference]

positive regulation of myelination

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of membrane protein ectodomain proteolysis

regulation of cellular catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of membrane protein ectodomain proteolysis

regulation of membrane protein ectodomain proteolysis [inference]

positive regulation of membrane protein ectodomain proteolysis

regulation of myelination [inference]

positive regulation of myelination

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of membrane protein ectodomain proteolysis

positive regulation of myelination

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of axonogenesis

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of axonogenesis

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

regulation of axonogenesis [inference]

positive regulation of axonogenesis

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of axonogenesis

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of nervous system process [inference]

positive regulation of nervous system process [inference]

positive regulation of myelination

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system process [inference]

positive regulation of myelination

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis

negative regulation of multicellular organismal process [inference]

negative regulation of cold-induced thermogenesis

regulation of cold-induced thermogenesis [inference]

negative regulation of cold-induced thermogenesis

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of myelination [inference]

positive regulation of myelination

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis

regulation of molecular function [inference]

regulation of catalytic activity [inference]

regulation of hydrolase activity [inference]

regulation of peptidase activity [inference]

regulation of endopeptidase activity

Displaying **all 2** entries
GO Term	Evidence Code	PMID
dendrite	IEA
mitochondrion	HDA ISO	18614015

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

dendrite

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	15809022 19935654
metal ion binding	IEA
metalloendopeptidase activity	IEA
peptidase activity	ISO	15809022

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity [inference]

metalloendopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity [inference]

metalloendopeptidase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

nardilysin

Functional Category

C: Energy production and conversion
H: Coenzyme transport and metabolism
I: Lipid transport and metabolism

Displaying **all 9** entries
Gene Ontology
amyloid-beta metabolic process
hormone catabolic process
hydrolase activity
metal ion binding
metalloendopeptidase activity
metallopeptidase activity
peptide catabolic process
proteolysis involved in protein catabolic process
proteolysis

Displaying **all 5** entries
InterPro
Metalloenzyme, LuxS/M16 peptidase-like
Peptidase M16, C-terminal
Peptidase M16, N-terminal
Peptidase M16, middle/third domain
Peptidase M16, zinc-binding site

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:1289	neurodegenerative disease	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **125** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	4898		HGNC:7995	HUMAN49860
Rattus norvegicus	25499	10116_1:00226d	RGD:3210	RATNO34532
Drosophila melanogaster	32143		FB:FBgn0030344
Drosophila melanogaster	40316		FB:FBgn0037037
Pan troglodytes	456852			PANTR21074
Canis lupus familiaris	475354			CANLF04017
Bos taurus	511254			BOVIN26951
Danio rerio	557565		ZFIN:ZDB-GENE-050208-422
Danio rerio	565850		ZFIN:ZDB-GENE-070912-417	DANRE28410
Monodelphis domestica	100011053			MONDO13579

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements