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WAPL cohesin release factor

Summary

Gene Symbol

WAPL

Organism

Homo sapiens (human)

External Links

NCBI Gene

23063

PubChem

23063

Alliance of Genome Resources

HGNC:23293

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Chromosome
Coiled coil
Cytoplasm
Host-virus interaction
Mitosis
Nucleus
Phosphoprotein
Reference proteome

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q7Z5K2	Friend of EBNA2 protein WAPL cohesin release factor
B2RTX8
A8K273

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
mitotic sister chromatid segregation	IMP	17113138
negative regulation of DNA replication	IMP	19907496
negative regulation of chromatin binding	IMP	17113138 19696148
negative regulation of sister chromatid cohesion	IMP	19696148 21111234
cell division	IEA

GO Hierarchy

biological process

cellular process [inference]

cell cycle process [inference]

chromosome segregation [inference]

nuclear chromosome segregation [inference]

sister chromatid segregation [inference]

mitotic sister chromatid segregation

mitotic cell cycle process [inference]

mitotic sister chromatid segregation

cell division

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to chromosome [inference]

protein localization to chromatin

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

chromosome organization [inference]

sister chromatid segregation [inference]

mitotic sister chromatid segregation

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to chromosome [inference]

protein localization to chromatin

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to chromosome [inference]

protein localization to chromatin

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

negative regulation of DNA replication

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

negative regulation of DNA replication

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication

regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

negative regulation of DNA replication

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

negative regulation of DNA replication

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication

negative regulation of cell cycle [inference]

negative regulation of cell cycle process [inference]

negative regulation of sister chromatid cohesion

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of chromosome organization [inference]

negative regulation of sister chromatid cohesion

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

negative regulation of DNA replication

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication

negative regulation of cell cycle [inference]

negative regulation of cell cycle process [inference]

negative regulation of sister chromatid cohesion

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of chromosome organization [inference]

negative regulation of sister chromatid cohesion

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

negative regulation of organelle organization [inference]

negative regulation of chromosome organization [inference]

negative regulation of sister chromatid cohesion

regulation of chromosome organization [inference]

regulation of sister chromatid cohesion [inference]

negative regulation of sister chromatid cohesion

negative regulation of chromosome organization [inference]

negative regulation of sister chromatid cohesion

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of chromosome organization [inference]

negative regulation of sister chromatid cohesion

regulation of cell cycle [inference]

regulation of cell cycle process [inference]

regulation of sister chromatid cohesion [inference]

negative regulation of sister chromatid cohesion

negative regulation of cell cycle process [inference]

negative regulation of sister chromatid cohesion

negative regulation of cell cycle [inference]

negative regulation of cell cycle process [inference]

negative regulation of sister chromatid cohesion

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of binding [inference]

negative regulation of chromatin binding

regulation of binding [inference]

regulation of chromatin binding [inference]

negative regulation of chromatin binding

negative regulation of binding [inference]

negative regulation of chromatin binding

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
chromosome, centromeric region	TAS
chromatin	IDA	17113138 19696148
nucleus	IDA	17113138 19696148
nucleoplasm	TAS
nucleoplasm	IDA

GO Hierarchy

cellular component

protein-containing complex [inference]

protein-DNA complex [inference]

chromatin

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

nucleus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

chromosome

spindle [inference]

mitotic spindle

intracellular organelle [inference]

intracellular membrane-bounded organelle

nucleus

intracellular non-membrane-bounded organelle [inference]

chromosome

spindle [inference]

mitotic spindle

intercellular bridge

chromosomal region [inference]

chromosome, centromeric region

Displaying **all 2** entries
GO Term	Evidence Code	PMID
protein binding	IPI	17112726 17113138 19696148 19907496 20360068 21111234 25173175 26496610 29263825 29867216 33961781 35271311
ATP-dependent protein-DNA unloader activity	IMP	17113138

GO Hierarchy

molecular function

catalytic activity [inference]

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on DNA [inference]

ATP-dependent activity, acting on DNA [inference]

ATP-dependent protein-DNA unloader activity

binding [inference]

protein binding

ATP-dependent activity [inference]

ATP-dependent activity, acting on DNA [inference]

ATP-dependent protein-DNA unloader activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

wings apart-like

Functional Category

G: Carbohydrate transport and metabolism
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
regulation of cohesin loading

Displaying **all 5** entries
InterPro
Armadillo-like helical
Armadillo-type fold
WAPL domain
Wings apart-like protein, C-terminal
Wings apart-like protein

Ortholog

Displaying entries **1 - 10** of 87 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	23063	Xenbase:XB-GENE-5886236
Mus musculus	218914	Xenbase:XB-GENE-5886236	MOUSE14224
Rattus norvegicus	290577		RATNO10665
Pan troglodytes	450568		PANTR01049
Bos taurus	534322		BOVIN22667
Danio rerio	553345		DANRE11719
Canis lupus familiaris	612854		CANLF14736
Macaca mulatta	700171		MACMU45975
Monodelphis domestica	100013552		MONDO04794
Ornithorhynchus anatinus	100085870		ORNAN17401