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endothelin converting enzyme 1

Summary

Gene Symbol

Ece1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

230857

PubChem

230857

Alliance of Genome Resources

MGI:1101357

Annotation

Keyword

Alternative splicing
Cell membrane
Disulfide bond
Glycoprotein
Metal-binding
Metalloprotease
Phosphoprotein
Reference proteome
Signal-anchor
Transmembrane helix
Zinc

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q4PZA2
A0A183ZRM3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 35 in total

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GO Term	Evidence Code	PMID
response to hypoxia	ISO
positive regulation of receptor recycling	ISO
positive regulation of receptor recycling	IEA
axon guidance	IMP	30735130
heart development	ISO

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing

endothelin maturation

peptide catabolic process [inference]

neuropeptide catabolic process [inference]

substance P catabolic process

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing

endothelin maturation

peptide catabolic process [inference]

neuropeptide catabolic process [inference]

substance P catabolic process

protein metabolic process [inference]

proteolysis [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

endothelin maturation

protein maturation [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

endothelin maturation

organonitrogen compound catabolic process [inference]

peptide catabolic process [inference]

neuropeptide catabolic process [inference]

substance P catabolic process

catabolic process [inference]

hormone catabolic process

calcitonin catabolic process

cellular catabolic process [inference]

peptide catabolic process [inference]

neuropeptide catabolic process [inference]

substance P catabolic process

organic substance catabolic process [inference]

organonitrogen compound catabolic process [inference]

peptide catabolic process [inference]

neuropeptide catabolic process [inference]

substance P catabolic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

hormone metabolic process [inference]

peptide hormone processing

endothelin maturation

hormone catabolic process

calcitonin catabolic process

cellular metabolic process [inference]

cellular catabolic process [inference]

peptide catabolic process [inference]

neuropeptide catabolic process [inference]

substance P catabolic process

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

endothelin maturation

protein maturation [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

endothelin maturation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

gene expression

protein metabolic process [inference]

proteolysis [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

endothelin maturation

protein maturation [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

endothelin maturation

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing

endothelin maturation

peptide catabolic process [inference]

neuropeptide catabolic process [inference]

substance P catabolic process

protein metabolic process [inference]

proteolysis [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

endothelin maturation

protein maturation [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

endothelin maturation

organonitrogen compound catabolic process [inference]

peptide catabolic process [inference]

neuropeptide catabolic process [inference]

substance P catabolic process

organic substance catabolic process [inference]

organonitrogen compound catabolic process [inference]

peptide catabolic process [inference]

neuropeptide catabolic process [inference]

substance P catabolic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

semaphorin-plexin signaling pathway [inference]

semaphorin-plexin signaling pathway involved in neuron projection guidance [inference]

semaphorin-plexin signaling pathway involved in axon guidance

cellular metabolic process [inference]

cellular catabolic process [inference]

peptide catabolic process [inference]

neuropeptide catabolic process [inference]

substance P catabolic process

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

axonogenesis [inference]

axonogenesis involved in innervation

plasma membrane bounded cell projection organization [inference]

neuron projection development

neuron projection guidance [inference]

axon guidance

sympathetic neuron axon guidance

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

blood vessel diameter maintenance

developmental process [inference]

anatomical structure morphogenesis [inference]

cellular anatomical entity morphogenesis [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

axonogenesis [inference]

axonogenesis involved in innervation

embryonic morphogenesis [inference]

embryonic digit morphogenesis

anatomical structure development [inference]

tissue development [inference]

epithelium development [inference]

embryonic heart tube development

tube development [inference]

embryonic heart tube development

animal organ development [inference]

sensory organ development [inference]

ear development

heart development

system development [inference]

pharyngeal system development

response to stimulus [inference]

response to stress [inference]

response to hypoxia

response to abiotic stimulus [inference]

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of receptor recycling

regulation of macromolecule metabolic process [inference]

regulation of receptor recycling [inference]

positive regulation of receptor recycling

positive regulation of macromolecule metabolic process [inference]

positive regulation of receptor recycling

regulation of signaling [inference]

regulation of receptor recycling [inference]

positive regulation of receptor recycling

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of cAMP-mediated signaling

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

regulation of ERK1 and ERK2 cascade

regulation of cAMP-mediated signaling [inference]

positive regulation of cAMP-mediated signaling

positive regulation of intracellular signal transduction [inference]

positive regulation of cAMP-mediated signaling

positive regulation of signaling [inference]

positive regulation of receptor recycling

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of cAMP-mediated signaling

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of receptor recycling

positive regulation of signaling [inference]

positive regulation of receptor recycling

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of cAMP-mediated signaling

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of cAMP-mediated signaling

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of cAMP-mediated signaling

positive regulation of multicellular organismal process [inference]

positive regulation of muscle hypertrophy [inference]

positive regulation of cardiac muscle hypertrophy

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of cAMP-mediated signaling

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

regulation of ERK1 and ERK2 cascade

regulation of cAMP-mediated signaling [inference]

positive regulation of cAMP-mediated signaling

positive regulation of intracellular signal transduction [inference]

positive regulation of cAMP-mediated signaling

regulation of muscle adaptation [inference]

regulation of cardiac muscle hypertrophy [inference]

positive regulation of cardiac muscle hypertrophy

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of cAMP-mediated signaling

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

semaphorin-plexin signaling pathway [inference]

semaphorin-plexin signaling pathway involved in neuron projection guidance [inference]

semaphorin-plexin signaling pathway involved in axon guidance

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of cAMP-mediated signaling

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

regulation of ERK1 and ERK2 cascade

regulation of cAMP-mediated signaling [inference]

positive regulation of cAMP-mediated signaling

positive regulation of intracellular signal transduction [inference]

positive regulation of cAMP-mediated signaling

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of cAMP-mediated signaling

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of cAMP-mediated signaling

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of muscle system process [inference]

regulation of muscle hypertrophy [inference]

regulation of cardiac muscle hypertrophy [inference]

positive regulation of cardiac muscle hypertrophy

positive regulation of muscle hypertrophy [inference]

positive regulation of cardiac muscle hypertrophy

regulation of muscle adaptation [inference]

regulation of cardiac muscle hypertrophy [inference]

positive regulation of cardiac muscle hypertrophy

positive regulation of multicellular organismal process [inference]

positive regulation of muscle hypertrophy [inference]

positive regulation of cardiac muscle hypertrophy

regulation of biological quality [inference]

regulation of blood pressure

regulation of hormone levels [inference]

hormone metabolic process [inference]

peptide hormone processing

endothelin maturation

hormone catabolic process

calcitonin catabolic process

regulation of anatomical structure size [inference]

regulation of tube size [inference]

regulation of tube diameter [inference]

blood vessel diameter maintenance

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
endosome	ISO
endosome	IEA
early endosome	ISO
Golgi apparatus	ISS	8062389
plasma membrane	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cell surface

membrane

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

early endosome

coated vesicle [inference]

clathrin-coated vesicle [inference]

Weibel-Palade body

secretory vesicle [inference]

secretory granule

Weibel-Palade body

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

early endosome

coated vesicle [inference]

clathrin-coated vesicle [inference]

Weibel-Palade body

secretory vesicle [inference]

secretory granule

Weibel-Palade body

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

early endosome

coated vesicle [inference]

clathrin-coated vesicle [inference]

Weibel-Palade body

secretory vesicle [inference]

secretory granule

Weibel-Palade body

perinuclear region of cytoplasm

side of membrane [inference]

external side of plasma membrane

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
endopeptidase activity	ISO
metalloendopeptidase activity	IBA
metalloendopeptidase activity	IEA
peptidase activity	ISS	8062389
zinc ion binding	ISO

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity

endopeptidase activity

metalloendopeptidase activity

metallopeptidase activity [inference]

metalloendopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity

endopeptidase activity

metalloendopeptidase activity

metallopeptidase activity [inference]

metalloendopeptidase activity

binding [inference]

protein binding [inference]

identical protein binding

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

endothelin-converting enzyme

Functional Category

J: Translation, ribosomal structure and biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
hydrolase activity
metal ion binding
metalloendopeptidase activity
metallopeptidase activity
proteolysis

Displaying **all 5** entries
InterPro
Metallopeptidase, catalytic domain superfamily
Peptidase M13, C-terminal domain
Peptidase M13, N-terminal domain
Peptidase M13, domain 2
Peptidase M13

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:6406	double outlet right ventricle	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements