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tripartite motif containing 35

Summary

Gene Symbol

TRIM35

Organism

Homo sapiens (human)

External Links

NCBI Gene

23087

PubChem

23087

Alliance of Genome Resources

HGNC:16285

Annotation

Keyword

Acetylation
Alternative splicing
Apoptosis
Coiled coil
Cytoplasm
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome
Transferase
Ubl conjugation pathway
Zinc-finger

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q9UPQ4	Hemopoietic lineage switch protein 5
E5RGB3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
apoptotic process	IEA
protein ubiquitination	IEA
positive regulation of apoptotic process	IDA	14662771
positive regulation of apoptotic process	IBA
suppression of viral release by host	IDA	18248090

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

innate immune response

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

macromolecule modification [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

cellular process [inference]

cell death [inference]

programmed cell death [inference]

apoptotic process

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to virus [inference]

defense response to virus [inference]

suppression of viral release by host

defense response to other organism [inference]

innate immune response

defense response to symbiont [inference]

defense response to virus [inference]

suppression of viral release by host

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

innate immune response

defense response to symbiont [inference]

defense response to virus [inference]

suppression of viral release by host

immune response [inference]

innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus [inference]

defense response to virus [inference]

suppression of viral release by host

defense response to other organism [inference]

innate immune response

defense response to symbiont [inference]

defense response to virus [inference]

suppression of viral release by host

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus [inference]

defense response to virus [inference]

suppression of viral release by host

defense response to other organism [inference]

innate immune response

defense response to symbiont [inference]

defense response to virus [inference]

suppression of viral release by host

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell cycle [inference]

negative regulation of mitotic cell cycle

regulation of cellular process [inference]

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

negative regulation of cellular process [inference]

negative regulation of cell cycle [inference]

negative regulation of mitotic cell cycle

regulation of cell cycle [inference]

regulation of mitotic cell cycle [inference]

negative regulation of mitotic cell cycle

negative regulation of cell cycle [inference]

negative regulation of mitotic cell cycle

Displaying **all 3** entries
GO Term	Evidence Code	PMID
nucleus	ISS
cytoplasm	ISS
cytoplasm	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein binding	IPI	32296183 32814053
zinc ion binding	IEA
ubiquitin protein ligase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

acyltransferase activity [inference]

aminoacyltransferase activity [inference]

ubiquitin-like protein transferase activity [inference]

ubiquitin-protein transferase activity [inference]

ubiquitin protein ligase activity

ubiquitin-like protein ligase activity [inference]

ubiquitin protein ligase activity

catalytic activity, acting on a protein [inference]

ubiquitin-like protein transferase activity [inference]

ubiquitin-protein transferase activity [inference]

ubiquitin protein ligase activity

ubiquitin-like protein ligase activity [inference]

ubiquitin protein ligase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

e3 ubiquitin-protein ligase

Functional Category

K: Transcription
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
metal ion binding
protein ubiquitination
zinc ion binding

Displaying **all 10** entries
InterPro
B-box-type zinc finger
B30.2/SPRY domain superfamily
B30.2/SPRY domain
Butyrophylin-like, SPRY domain
Concanavalin A-like lectin/glucanase domain superfamily
SPRY domain
SPRY-associated
Zinc finger, RING-type, conserved site
Zinc finger, RING-type
Zinc finger, RING/FYVE/PHD-type

Ortholog

Displaying entries **1 - 10** of **292** in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	4210	WB:WBGene00022872
Caenorhabditis elegans	10475	WB:WBGene00022872
Caenorhabditis elegans	11074	WB:WBGene00022872
Danio rerio	23087	ZFIN:ZDB-GENE-140106-276
Caenorhabditis elegans	56658	WB:WBGene00022872
Mus musculus	66854		MOUSE12807
Caenorhabditis elegans	84676	WB:WBGene00016190
Caenorhabditis elegans	89870	WB:WBGene00022872
Caenorhabditis elegans	94089	WB:WBGene00022872
Caenorhabditis elegans	224762	WB:WBGene00022872