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F-box protein 2

Summary

Gene Symbol

Fbxo2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

230904

PubChem

230904

Alliance of Genome Resources

MGI:2446216

Annotation

Keyword

3D-structure
Cytoplasm
Lectin
Membrane
Microsome
Phosphoprotein
Reference proteome
Ubl conjugation pathway

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q3USR5
Q80UW2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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2

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GO Term	Evidence Code	PMID
regulation of protein ubiquitination	IDA	15809437
regulation of protein catabolic process at postsynapse, modulating synaptic transmission	IDA IMP	15809437
ubiquitin-dependent protein catabolic process	IDA	15723043
negative regulation of cell population proliferation	IEA ISO
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IBA IDA	12140560

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

glycoprotein metabolic process [inference]

glycoprotein catabolic process

protein catabolic process [inference]

glycoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

carbohydrate derivative catabolic process [inference]

glycoprotein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

glycoprotein metabolic process [inference]

glycoprotein catabolic process

protein catabolic process [inference]

glycoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

glycoprotein metabolic process [inference]

glycoprotein catabolic process

protein catabolic process [inference]

glycoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

macromolecule modification [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein catabolic process

carbohydrate derivative catabolic process [inference]

glycoprotein catabolic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

glycoprotein metabolic process [inference]

glycoprotein catabolic process

protein catabolic process [inference]

glycoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

carbohydrate derivative catabolic process [inference]

glycoprotein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

cellular process [inference]

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

ERAD pathway

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

ERAD pathway

response to chemical [inference]

response to organic substance [inference]

response to organonitrogen compound [inference]

ERAD pathway

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

ERAD pathway

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

ERAD pathway

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of catabolic process [inference]

regulation of protein catabolic process [inference]

regulation of protein catabolic process at postsynapse, modulating synaptic transmission

regulation of nitrogen compound metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of post-translational protein modification [inference]

regulation of protein modification by small protein conjugation or removal [inference]

regulation of protein ubiquitination

regulation of protein catabolic process [inference]

regulation of protein catabolic process at postsynapse, modulating synaptic transmission

regulation of macromolecule metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of post-translational protein modification [inference]

regulation of protein modification by small protein conjugation or removal [inference]

regulation of protein ubiquitination

regulation of protein catabolic process [inference]

regulation of protein catabolic process at postsynapse, modulating synaptic transmission

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of post-translational protein modification [inference]

regulation of protein modification by small protein conjugation or removal [inference]

regulation of protein ubiquitination

regulation of protein catabolic process [inference]

regulation of protein catabolic process at postsynapse, modulating synaptic transmission

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

postsynaptic modulation of chemical synaptic transmission [inference]

regulation of protein catabolic process at postsynapse, modulating synaptic transmission

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

postsynaptic modulation of chemical synaptic transmission [inference]

regulation of protein catabolic process at postsynapse, modulating synaptic transmission

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

Displaying entries **6 - 7** of 7 in total

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GO Term	Evidence Code	PMID
cytoplasm	IBA ISO
glutamatergic synapse	IDA IMP ISO	15809437

GO Hierarchy

cellular component

protein-containing complex [inference]

intracellular protein-containing complex [inference]

ubiquitin ligase complex [inference]

cullin-RING ubiquitin ligase complex [inference]

SCF ubiquitin ligase complex

catalytic complex [inference]

transferase complex [inference]

ubiquitin ligase complex [inference]

cullin-RING ubiquitin ligase complex [inference]

SCF ubiquitin ligase complex

cellular anatomical entity [inference]

extrinsic component of membrane [inference]

extrinsic component of plasma membrane [inference]

extrinsic component of synaptic membrane [inference]

extrinsic component of postsynaptic membrane

cell junction [inference]

synapse [inference]

glutamatergic synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

neuron spine [inference]

dendritic spine

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

postsynapse [inference]

dendritic spine

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IPI	15723043 15809437 17389369
denatured protein binding	IDA	15723043
ubiquitin protein ligase activity	IBA
amyloid-beta binding	IDA	9173930
carbohydrate binding	IDA	12939278

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

acyltransferase activity [inference]

aminoacyltransferase activity [inference]

ubiquitin-like protein transferase activity [inference]

ubiquitin-protein transferase activity [inference]

ubiquitin protein ligase activity

ubiquitin-like protein ligase activity [inference]

ubiquitin protein ligase activity

catalytic activity, acting on a protein [inference]

ubiquitin-like protein transferase activity [inference]

ubiquitin-protein transferase activity [inference]

ubiquitin protein ligase activity

ubiquitin-like protein ligase activity [inference]

ubiquitin protein ligase activity

binding [inference]

protein binding

denatured protein binding

carbohydrate binding

amide binding [inference]

peptide binding [inference]

amyloid-beta binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

F-box only protein 2

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
I: Lipid transport and metabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
glycoprotein catabolic process

Displaying **all 5** entries
InterPro
F-box associated (FBA) domain
F-box domain
F-box only protein
F-box-like domain superfamily
Galactose-binding-like domain superfamily

Ortholog

Displaying entries **81 - 90** of 94 in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Panthera leo	122227276		PANLE09798
Ursus americanus	123779107		URSAM05068
Marmota monax	124079195	9995_0:003b7e
Sciurus carolinensis	124982372	30640_0:0005f9
Perognathus longimembris pacificus	125354222	214514_0:001e42
Myodes glareolus	125417943	447135_0:000631
Microtus fortis	126508192	100897_0:002609
Acomys russatus	127211747	60746_0:0047d6
Phodopus roborovskii	127213351	109678_0:004c5d
Apodemus sylvaticus	127680189	10129_0:00108e