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signal induced proliferation associated 1 like 3

Summary

Gene Symbol

SIPA1L3

Organism

Homo sapiens (human)

External Links

NCBI Gene

23094

PubChem

23094

Alliance of Genome Resources

HGNC:23801

Annotation

Keyword

Acetylation
Cataract
Cell membrane
Chromosomal rearrangement
Coiled coil
GTPase activation
Phosphoprotein
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
O60292	SPA-1-like protein 3
B2RWP0

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
eye development	ISS
hematopoietic progenitor cell differentiation	IEA
epithelial cell morphogenesis	IDA	26231217
epithelial cell morphogenesis	IBA
cytoskeleton organization	ISS

GO Hierarchy

biological process

cellular process [inference]

establishment or maintenance of cell polarity [inference]

establishment of cell polarity [inference]

establishment of epithelial cell polarity

cellular developmental process [inference]

cell differentiation [inference]

hematopoietic progenitor cell differentiation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization

developmental process [inference]

anatomical structure morphogenesis [inference]

cell morphogenesis [inference]

epithelial cell morphogenesis

anatomical structure development [inference]

animal organ development [inference]

sensory organ development [inference]

eye development

cellular developmental process [inference]

cell differentiation [inference]

hematopoietic progenitor cell differentiation

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
stress fiber	IDA	26231217
extracellular space	HDA	22664934
nucleoplasm	IDA
cytoplasm	IBA
Golgi apparatus	IDA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

apical plasma membrane

cell junction [inference]

synapse [inference]

glutamatergic synapse

anchoring junction [inference]

cell-cell junction [inference]

tight junction [inference]

tricellular tight junction

actin filament bundle [inference]

contractile actin filament bundle [inference]

stress fiber

actomyosin [inference]

stress fiber

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

postsynaptic specialization, intracellular component

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular non-membrane-bounded organelle [inference]

postsynaptic specialization, intracellular component

apical part of cell

Displaying **all 2** entries
GO Term	Evidence Code	PMID
GTPase activator activity	IBA
protein binding	IPI	15161933 15778465 28514442 33961781 35271311 36931259

GO Hierarchy

molecular function

binding [inference]

protein binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

nucleoside-triphosphatase regulator activity [inference]

GTPase regulator activity [inference]

GTPase activator activity

molecular function activator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

signal-induced proliferation-associated 1

Functional Category

E: Amino acid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
regulation of small GTPase mediated signal transduction

Displaying **all 4** entries
InterPro
PDZ domain
PDZ superfamily
Rap/Ran-GAP domain
Rap/Ran-GAP superfamily

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0110262	cataract 45	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 78 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	6494	WB:WBGene00012100
Xenopus laevis	23094	Xenbase:XB-GENE-6487557
Caenorhabditis elegans	26037	WB:WBGene00012100
Caenorhabditis elegans	57568	WB:WBGene00012100
Mus musculus	74206	ZFIN:ZDB-GENE-050420-109	MOUSE54511
Caenorhabditis elegans	217692	WB:WBGene00012100
Caenorhabditis elegans	244668	WB:WBGene00012100
Rattus norvegicus	292771		RATNO19376
Pan troglodytes	468861		PANTR18153
Bos taurus	513625		BOVIN10984

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements