GlyCosmos Portal

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GO Term	Evidence Code	PMID
membrane	IDA	25947375
phospholipid-translocating ATPase complex	IDA IPI	25947375
endoplasmic reticulum membrane	IEA
plasma membrane	IBA
late endosome membrane	IDA	26567335

GO Hierarchy

cellular component

protein-containing complex [inference]

transporter complex [inference]

phospholipid-translocating ATPase complex

cellular anatomical entity [inference]

membrane

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane [inference]

late endosome membrane

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

endosome membrane [inference]

late endosome membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

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GO Term	Evidence Code	PMID
protein binding	IPI	21914794 25947375 32172343
ATP hydrolysis activity	IEA
glycosylceramide flippase activity	IDA	32172343
magnesium ion binding	IEA
ATP binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

transporter activity [inference]

lipid transporter activity [inference]

phospholipid transporter activity [inference]

phosphatidylcholine transporter activity [inference]

phosphatidylcholine flippase activity

glycerophospholipid flippase activity [inference]

phosphatidylcholine flippase activity

sphingolipid transporter activity [inference]

glycosylceramide flippase activity

intramembrane lipid transporter activity [inference]

ATPase-coupled intramembrane lipid transporter activity

flippase activity [inference]

glycerophospholipid flippase activity [inference]

phosphatidylcholine flippase activity

glycosylceramide flippase activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding [inference]

magnesium ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

ATPase-coupled intramembrane lipid transporter activity

flippase activity [inference]

glycerophospholipid flippase activity [inference]

phosphatidylcholine flippase activity

glycosylceramide flippase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

transporter

Functional Category

C: Energy production and conversion
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
ATP binding
lipid translocation
magnesium ion binding
metal ion binding
nucleotide binding
phospholipid translocation
phospholipid transport

Displaying entries **1 - 10** of 11 in total

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InterPro
HAD superfamily
HAD-like superfamily
P-type ATPase, A domain superfamily
P-type ATPase, C-terminal
P-type ATPase, N-terminal
P-type ATPase, cytoplasmic domain N
P-type ATPase, haloacid dehalogenase domain
P-type ATPase, phosphorylation site
P-type ATPase, subfamily IV
P-type ATPase, transmembrane domain superfamily

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0070221	progressive familial intrahepatic cholestasis	Alliance of Genome Resources

Ortholog

Displaying entries **21 - 30** of 69 in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Oreochromis niloticus	100710966		ORENI46743
Cavia porcellus	100718505		CAVPO09328
Sarcophilus harrisii	100935347		SARHA19323
Pan paniscus	100977504	9597_0:001726	PANPA33079
Papio anubis	101002006		PAPAN33117
Saimiri boliviensis boliviensis	101039829		SAIBB24192
Felis catus	101084853		FELCA00873
Ovis aries	101117246		SHEEP17001
Gorilla gorilla gorilla	101149030	9595_0:001a11	GORGO33955
Tursiops truncatus	101323858		TURTR07834

GlyTouCan

GlyComb

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LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements