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erythrocyte membrane protein band 4.1 like 3

Summary

Gene Symbol

EPB41L3

Organism

Homo sapiens (human)

External Links

NCBI Gene

23136

PubChem

23136

Alliance of Genome Resources

HGNC:3380

Annotation

Keyword

3D-structure
Acetylation
Actin-binding
Alternative splicing
Apoptosis
Cell junction
Cell membrane
Cytoskeleton
Phosphoprotein
Proteomics identification
Reference proteome
Tumor suppressor

Proteins

Displaying **all 3** entries
UniProt	Protein Name
A8K968
A0A0A0MRA8
Q9Y2J2	4.1B Differentially expressed in adenocarcinoma of the lung protein 1 Erythrocyte membrane protein band 4.1-like 3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
protein localization to paranode region of axon	ISS
apoptotic process	IEA
biological_process	ND
regulation of cell shape	ISS
cortical cytoskeleton organization	TAS	21966409

GO Hierarchy

biological process

cellular process [inference]

cell death [inference]

programmed cell death [inference]

apoptotic process

actin filament-based process [inference]

actin cytoskeleton organization [inference]

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

protein localization to axon [inference]

protein localization to cell periphery [inference]

protein localization to plasma membrane

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

actin cytoskeleton organization [inference]

cortical cytoskeleton organization

cortical actin cytoskeleton organization

cellular component assembly [inference]

cellular component assembly involved in morphogenesis [inference]

paranodal junction assembly

cell junction assembly [inference]

cell-cell junction assembly [inference]

paranodal junction assembly

cell projection organization [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis

cell junction organization [inference]

cell junction assembly [inference]

cell-cell junction assembly [inference]

paranodal junction assembly

cell-cell junction organization [inference]

cell-cell junction assembly [inference]

paranodal junction assembly

membrane organization [inference]

plasma membrane organization [inference]

myelin maintenance

developmental process [inference]

anatomical structure morphogenesis [inference]

cellular anatomical entity morphogenesis [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis

anatomical structure formation involved in morphogenesis [inference]

cellular component assembly involved in morphogenesis [inference]

paranodal junction assembly

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

protein localization to axon [inference]

protein localization to cell periphery [inference]

protein localization to plasma membrane

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

protein localization to axon [inference]

protein localization to cell periphery [inference]

protein localization to plasma membrane

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of protein localization to synapse [inference]

regulation of neurotransmitter receptor localization to postsynaptic specialization membrane

regulation of protein localization to cell periphery [inference]

regulation of neurotransmitter receptor localization to postsynaptic specialization membrane

regulation of protein localization to membrane [inference]

regulation of neurotransmitter receptor localization to postsynaptic specialization membrane

regulation of receptor localization to synapse [inference]

regulation of neurotransmitter receptor localization to postsynaptic specialization membrane

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of cell morphogenesis [inference]

regulation of cell shape

regulation of cellular process [inference]

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of protein localization to synapse [inference]

regulation of neurotransmitter receptor localization to postsynaptic specialization membrane

regulation of protein localization to cell periphery [inference]

regulation of neurotransmitter receptor localization to postsynaptic specialization membrane

regulation of protein localization to membrane [inference]

regulation of neurotransmitter receptor localization to postsynaptic specialization membrane

regulation of biological quality [inference]

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
cytosol	TAS
cytosol	IDA
cytoskeleton	IBA
plasma membrane	NAS	9892180
plasma membrane	IDA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

microtubule organizing center [inference]

ciliary basal body

cytosol

membrane [inference]

plasma membrane

plasma membrane region [inference]

cell projection membrane [inference]

neuron projection membrane [inference]

axolemma

cell junction

synapse [inference]

glutamatergic synapse

anchoring junction [inference]

cell-cell junction

leading edge membrane [inference]

neuron projection membrane [inference]

axolemma

paranode region of axon

cell projection [inference]

plasma membrane bounded cell projection [inference]

cilium

organelle [inference]

membrane-bounded organelle [inference]

cilium

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

Displaying **all 4** entries
GO Term	Evidence Code	PMID
actin binding	IEA
structural constituent of cytoskeleton	TAS	21966409
protein binding	IPI	12234973 20936779 24366813 25416956 32296183 33961781 36931259
cytoskeletal protein-membrane anchor activity	TAS	21966409

GO Hierarchy

molecular function

structural molecule activity [inference]

structural constituent of cytoskeleton

binding [inference]

protein binding

cytoskeletal protein binding [inference]

actin binding

molecular adaptor activity [inference]

protein-macromolecule adaptor activity [inference]

cytoskeletal anchor activity [inference]

cytoskeletal protein-membrane anchor activity

protein-membrane adaptor activity [inference]

cytoskeletal protein-membrane anchor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

band 4.1-like protein

Functional Category

J: Translation, ribosomal structure and biogenesis
K: Transcription
T: Signal transduction mechanisms

Displaying **all 8** entries
InterPro
FERM adjacent
FERM central domain
FERM conserved site
FERM domain
FERM superfamily, second domain
FERM, C-terminal PH-like domain
FERM/acyl-CoA-binding protein superfamily
PH-like domain superfamily

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:3748	esophagus squamous cell carcinoma	Alliance of Genome Resources

Ortholog

Displaying entries **21 - 30** of 71 in total

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Species	Gene ID	Orthologous MAtrix
Callithrix jacchus	100400936	CALJA09234
Ailuropoda melanoleuca	100464679	AILME06953
Nomascus leucogenys	100594794	NOMLE27939
Loxodonta africana	100659315	LOXAF18573
Oreochromis niloticus	100689759	ORENI29737
Cavia porcellus	100715665	CAVPO20714
Cricetulus griseus	100751173	CRIGR15647
Sarcophilus harrisii	100923486	SARHA15764
Pan paniscus	100985229	PANPA18346
Saimiri boliviensis boliviensis	101038195	SAIBB08269