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Guidelines

MIRAGE

midasin AAA ATPase 1

Summary

Gene Symbol

MDN1

Organism

Homo sapiens (human)

External Links

NCBI Gene

23195

PubChem

23195

Alliance of Genome Resources

HGNC:18302

Annotation

Keyword

3D-structure
ATP-binding
Acetylation
Chaperone
Cytoplasm
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome
Repeat

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9NU22	Dynein-related AAA-ATPase MDN1 MIDAS-containing protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
ribosomal large subunit assembly	IDA	27814492
ribosomal large subunit assembly	IBA
ribosomal large subunit export from nucleus	IBA

GO Hierarchy

biological process

cellular process [inference]

cellular localization [inference]

intracellular transport [inference]

nuclear transport [inference]

nucleocytoplasmic transport [inference]

nuclear export [inference]

ribosomal subunit export from nucleus [inference]

ribosomal large subunit export from nucleus

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein-RNA complex assembly [inference]

ribosomal large subunit assembly

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein-RNA complex assembly [inference]

ribosomal large subunit assembly

protein-RNA complex organization [inference]

protein-RNA complex assembly [inference]

ribosomal large subunit assembly

localization [inference]

protein-containing complex localization [inference]

ribosomal subunit export from nucleus [inference]

ribosomal large subunit export from nucleus

establishment of localization [inference]

transport [inference]

intracellular transport [inference]

nuclear transport [inference]

nucleocytoplasmic transport [inference]

nuclear export [inference]

ribosomal subunit export from nucleus [inference]

ribosomal large subunit export from nucleus

establishment of localization in cell [inference]

intracellular transport [inference]

nuclear transport [inference]

nucleocytoplasmic transport [inference]

nuclear export [inference]

ribosomal subunit export from nucleus [inference]

ribosomal large subunit export from nucleus

establishment of organelle localization [inference]

ribosomal subunit export from nucleus [inference]

ribosomal large subunit export from nucleus

organelle localization [inference]

ribosome localization [inference]

ribosomal subunit export from nucleus [inference]

ribosomal large subunit export from nucleus

establishment of organelle localization [inference]

ribosomal subunit export from nucleus [inference]

ribosomal large subunit export from nucleus

cellular localization [inference]

intracellular transport [inference]

nuclear transport [inference]

nucleocytoplasmic transport [inference]

nuclear export [inference]

ribosomal subunit export from nucleus [inference]

ribosomal large subunit export from nucleus

Displaying entries **1 - 5** of 8 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
nucleus	IDA	27814492
nucleus	IBA
nucleoplasm	IDA
nucleolus	IDA
cytosol	IDA

GO Hierarchy

cellular component

protein-containing complex [inference]

ribonucleoprotein complex [inference]

preribosome [inference]

preribosome, large subunit precursor

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

nucleolus

cytoskeleton [inference]

intermediate filament cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

nucleolus

cytoskeleton [inference]

intermediate filament cytoskeleton

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein binding	IPI	21326211
ATP binding	IEA
ATP hydrolysis activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Midasin

Functional Category

L: Replication, recombination and repair
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
ATP binding
nucleotide binding

Displaying **all 8** entries
InterPro
AAA+ ATPase domain
ATPase, dynein-related, AAA domain
Midasin AAA lid domain 5
Midasin, AAA lid domain 7
Midasin
P-loop containing nucleoside triphosphate hydrolase
von Willebrand factor A-like domain superfamily
von Willebrand factor, type A

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025