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spectrin repeat containing nuclear envelope protein 2

Summary

Gene Symbol

SYNE2

Organism

Homo sapiens (human)

External Links

NCBI Gene

23224

PubChem

23224

Alliance of Genome Resources

HGNC:17084

Annotation

Keyword

3D-structure
Acetylation
Actin-binding
Alternative splicing
Cell junction
Cell membrane
Coiled coil
Cytoskeleton
Disease variant
Disulfide bond
Emery-Dreifuss muscular dystrophy
Mitochondrion
Nucleus
Phosphoprotein
Reference proteome
Repeat
Sarcoplasmic reticulum
Transmembrane helix
Ubl conjugation

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q8WXH0	KASH domain-containing protein 2 Nuclear envelope spectrin repeat protein 2 Nucleus and actin connecting element protein Synaptic nuclear envelope protein 2
Q6MZP0

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
nuclear migration	IMP	20724637
nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration	IEA
positive regulation of cell migration	ISS
nuclear migration along microfilament	ISS
centrosome localization	IMP	20724637

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process [inference]

microtubule-based movement [inference]

transport along microtubule [inference]

organelle transport along microtubule [inference]

nuclear migration along microtubule [inference]

nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration

actin filament-based process [inference]

actin filament-based movement [inference]

nuclear migration along microfilament

cellular localization [inference]

intracellular transport [inference]

nuclear migration

nuclear migration along microtubule [inference]

nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration

nuclear migration along microfilament

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

organelle transport along microtubule [inference]

nuclear migration along microtubule [inference]

nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration

actin filament-based transport [inference]

nuclear migration along microfilament

microtubule organizing center localization [inference]

centrosome localization

localization [inference]

establishment of localization [inference]

transport [inference]

intracellular transport [inference]

nuclear migration

nuclear migration along microtubule [inference]

nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration

nuclear migration along microfilament

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

organelle transport along microtubule [inference]

nuclear migration along microtubule [inference]

nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration

actin filament-based transport [inference]

nuclear migration along microfilament

microtubule-based transport [inference]

transport along microtubule [inference]

organelle transport along microtubule [inference]

nuclear migration along microtubule [inference]

nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration

establishment of localization in cell [inference]

intracellular transport [inference]

nuclear migration

nuclear migration along microtubule [inference]

nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration

nuclear migration along microfilament

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

organelle transport along microtubule [inference]

nuclear migration along microtubule [inference]

nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration

actin filament-based transport [inference]

nuclear migration along microfilament

establishment of organelle localization [inference]

nuclear migration

nuclear migration along microtubule [inference]

nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration

nuclear migration along microfilament

organelle transport along microtubule [inference]

nuclear migration along microtubule [inference]

nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration

organelle localization [inference]

nucleus localization [inference]

nuclear migration

nuclear migration along microtubule [inference]

nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration

nuclear migration along microfilament

establishment of organelle localization [inference]

nuclear migration

nuclear migration along microtubule [inference]

nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration

nuclear migration along microfilament

organelle transport along microtubule [inference]

nuclear migration along microtubule [inference]

nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration

cellular localization [inference]

intracellular transport [inference]

nuclear migration

nuclear migration along microtubule [inference]

nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration

nuclear migration along microfilament

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

organelle transport along microtubule [inference]

nuclear migration along microtubule [inference]

nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration

actin filament-based transport [inference]

nuclear migration along microfilament

microtubule organizing center localization [inference]

centrosome localization

biological regulation [inference]

regulation of biological process [inference]

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of biological process [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of cellular process [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of cellular process [inference]

regulation of cellular component biogenesis [inference]

regulation of cell projection assembly [inference]

regulation of plasma membrane bounded cell projection assembly [inference]

regulation of cilium assembly

regulation of organelle assembly [inference]

regulation of cilium assembly

positive regulation of cellular process [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

regulation of cell projection assembly [inference]

regulation of plasma membrane bounded cell projection assembly [inference]

regulation of cilium assembly

regulation of plasma membrane bounded cell projection organization [inference]

regulation of plasma membrane bounded cell projection assembly [inference]

regulation of cilium assembly

regulation of organelle organization [inference]

regulation of organelle assembly [inference]

regulation of cilium assembly

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

Displaying entries **1 - 5** of 19 in total

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GO Term	Evidence Code	PMID
fibrillar center	IDA
nucleus	IDA	12118075
nuclear envelope	IDA	15671068
nuclear outer membrane	IEA
nucleoplasm	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

nuclear membrane protein complex [inference]

nuclear membrane microtubule tethering complex [inference]

meiotic nuclear membrane microtubule tethering complex

nuclear protein-containing complex [inference]

nuclear membrane protein complex [inference]

nuclear membrane microtubule tethering complex [inference]

meiotic nuclear membrane microtubule tethering complex

cellular anatomical entity [inference]

membrane [inference]

outer membrane [inference]

organelle outer membrane [inference]

nuclear outer membrane

organelle membrane [inference]

endoplasmic reticulum membrane [inference]

sarcoplasmic reticulum membrane

nuclear membrane

nuclear outer membrane

bounding membrane of organelle [inference]

organelle outer membrane [inference]

nuclear outer membrane

sarcoplasmic reticulum membrane

plasma membrane region [inference]

cell projection membrane [inference]

Z disc

cell junction [inference]

anchoring junction [inference]

cell-substrate junction [inference]

focal adhesion

leading edge membrane [inference]

lamellipodium membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

nuclear lumen

envelope [inference]

organelle envelope [inference]

nuclear envelope

cell projection [inference]

plasma membrane bounded cell projection [inference]

cilium

organelle [inference]

membrane-bounded organelle [inference]

cilium

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum [inference]

sarcoplasmic reticulum

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

intermediate filament cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum [inference]

sarcoplasmic reticulum

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

intermediate filament cytoskeleton

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 3** entries
GO Term	Evidence Code	PMID
actin binding	ISS
protein binding	IPI	15671068 17462627 18396275 19933576 22555292 22632968 23414517 23977161 24880667 26506308 28716842 30833792 32296183 33058875 34818527
cytoskeleton-nuclear membrane anchor activity	IDA	18396275

GO Hierarchy

molecular function

binding [inference]

protein binding

cytoskeletal protein binding [inference]

actin binding

molecular adaptor activity [inference]

protein-macromolecule adaptor activity [inference]

protein-membrane adaptor activity [inference]

cytoskeleton-nuclear membrane anchor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

alpha-actinin A

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
InterPro
Calponin homology domain

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0070250	autosomal dominant Emery-Dreifuss muscular dystrophy 5	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 41 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Danio rerio	23224	ZFIN:ZDB-GENE-041001-109
Drosophila melanogaster	23345	FB:FBgn0261836
Drosophila melanogaster	64009	FB:FBgn0261836
Mus musculus	319565	ZFIN:ZDB-GENE-041001-109	MOUSE09140
Rattus norvegicus	366669		RATNO36619
Canis lupus familiaris	490729		CANLF17988
Bos taurus	540504		BOVIN01540
Macaca mulatta	706759		MACMU41795
Danio rerio	3771968	ZFIN:ZDB-GENE-041001-109
Ornithorhynchus anatinus	100081014		ORNAN05762