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phospholipase C like 2

Summary

Gene Symbol

PLCL2

Organism

Homo sapiens (human)

External Links

NCBI Gene

23228

PubChem

23228

Alliance of Genome Resources

HGNC:9064

Annotation

Keyword

Acetylation
Alternative splicing
Cytoplasm
Phosphoprotein
Reference proteome
Transducer

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9UPR0	Phospholipase C-epsilon-2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
B cell proliferation involved in immune response	IEA
B-1a B cell differentiation	IEA
lipid metabolic process
gamma-aminobutyric acid signaling pathway	IBA
regulation of synaptic transmission, GABAergic	IBA

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

B cell proliferation involved in immune response

leukocyte activation [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

B cell proliferation involved in immune response

lymphocyte activation [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

B cell proliferation involved in immune response

lymphocyte differentiation [inference]

B cell differentiation [inference]

mature B cell differentiation [inference]

B-1 B cell differentiation [inference]

B-1a B cell differentiation

B cell activation [inference]

B cell activation involved in immune response [inference]

B cell proliferation involved in immune response

B cell differentiation [inference]

mature B cell differentiation [inference]

B-1 B cell differentiation [inference]

B-1a B cell differentiation

B cell proliferation [inference]

B cell proliferation involved in immune response

lymphocyte proliferation [inference]

B cell proliferation [inference]

B cell proliferation involved in immune response

metabolic process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

primary metabolic process [inference]

lipid metabolic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

organic substance metabolic process [inference]

lipid metabolic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

cellular process [inference]

cell activation [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

B cell proliferation involved in immune response

leukocyte activation [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

B cell proliferation involved in immune response

lymphocyte activation [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

B cell proliferation involved in immune response

lymphocyte differentiation [inference]

B cell differentiation [inference]

mature B cell differentiation [inference]

B-1 B cell differentiation [inference]

B-1a B cell differentiation

B cell activation [inference]

B cell activation involved in immune response [inference]

B cell proliferation involved in immune response

B cell differentiation [inference]

mature B cell differentiation [inference]

B-1 B cell differentiation [inference]

B-1a B cell differentiation

B cell proliferation [inference]

B cell proliferation involved in immune response

lymphocyte proliferation [inference]

B cell proliferation [inference]

B cell proliferation involved in immune response

cell communication [inference]

cell-cell signaling [inference]

gamma-aminobutyric acid signaling pathway

signal transduction [inference]

intracellular signal transduction

phosphatidylinositol-mediated signaling

cell population proliferation [inference]

leukocyte proliferation [inference]

mononuclear cell proliferation [inference]

lymphocyte proliferation [inference]

B cell proliferation [inference]

B cell proliferation involved in immune response

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

mononuclear cell differentiation [inference]

lymphocyte differentiation [inference]

B cell differentiation [inference]

mature B cell differentiation [inference]

B-1 B cell differentiation [inference]

B-1a B cell differentiation

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

multicellular organismal process [inference]

cell activation [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

B cell proliferation involved in immune response

leukocyte activation [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

B cell proliferation involved in immune response

lymphocyte activation [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

B cell proliferation involved in immune response

lymphocyte differentiation [inference]

B cell differentiation [inference]

mature B cell differentiation [inference]

B-1 B cell differentiation [inference]

B-1a B cell differentiation

B cell activation [inference]

B cell activation involved in immune response [inference]

B cell proliferation involved in immune response

B cell differentiation [inference]

mature B cell differentiation [inference]

B-1 B cell differentiation [inference]

B-1a B cell differentiation

B cell proliferation [inference]

B cell proliferation involved in immune response

lymphocyte proliferation [inference]

B cell proliferation [inference]

B cell proliferation involved in immune response

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

mononuclear cell differentiation [inference]

lymphocyte differentiation [inference]

B cell differentiation [inference]

mature B cell differentiation [inference]

B-1 B cell differentiation [inference]

B-1a B cell differentiation

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

calcium ion transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

organic substance transport [inference]

calcium ion transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of antigen receptor-mediated signaling pathway [inference]

negative regulation of B cell receptor signaling pathway

regulation of immune response [inference]

regulation of antigen receptor-mediated signaling pathway [inference]

regulation of B cell receptor signaling pathway [inference]

negative regulation of B cell receptor signaling pathway

negative regulation of antigen receptor-mediated signaling pathway [inference]

negative regulation of B cell receptor signaling pathway

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of cold-induced thermogenesis

regulation of cold-induced thermogenesis [inference]

negative regulation of cold-induced thermogenesis

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of antigen receptor-mediated signaling pathway [inference]

negative regulation of B cell receptor signaling pathway

regulation of antigen receptor-mediated signaling pathway [inference]

regulation of B cell receptor signaling pathway [inference]

negative regulation of B cell receptor signaling pathway

negative regulation of antigen receptor-mediated signaling pathway [inference]

negative regulation of B cell receptor signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of antigen receptor-mediated signaling pathway [inference]

negative regulation of B cell receptor signaling pathway

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic transmission, GABAergic

signaling [inference]

cell-cell signaling [inference]

gamma-aminobutyric acid signaling pathway

regulation of localization [inference]

regulation of sequestering of calcium ion [inference]

negative regulation of sequestering of calcium ion [inference]

release of sequestered calcium ion into cytosol

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of antigen receptor-mediated signaling pathway [inference]

negative regulation of B cell receptor signaling pathway

negative regulation of metabolic process [inference]

negative regulation of cold-induced thermogenesis

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of antigen receptor-mediated signaling pathway [inference]

negative regulation of B cell receptor signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of antigen receptor-mediated signaling pathway [inference]

negative regulation of B cell receptor signaling pathway

negative regulation of sequestering of calcium ion [inference]

release of sequestered calcium ion into cytosol

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of antigen receptor-mediated signaling pathway [inference]

negative regulation of B cell receptor signaling pathway

negative regulation of multicellular organismal process [inference]

negative regulation of cold-induced thermogenesis

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of antigen receptor-mediated signaling pathway [inference]

negative regulation of B cell receptor signaling pathway

regulation of antigen receptor-mediated signaling pathway [inference]

regulation of B cell receptor signaling pathway [inference]

negative regulation of B cell receptor signaling pathway

negative regulation of antigen receptor-mediated signaling pathway [inference]

negative regulation of B cell receptor signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of antigen receptor-mediated signaling pathway [inference]

negative regulation of B cell receptor signaling pathway

regulation of immune response [inference]

regulation of antigen receptor-mediated signaling pathway [inference]

regulation of B cell receptor signaling pathway [inference]

negative regulation of B cell receptor signaling pathway

negative regulation of antigen receptor-mediated signaling pathway [inference]

negative regulation of B cell receptor signaling pathway

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction

phosphatidylinositol-mediated signaling

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of antigen receptor-mediated signaling pathway [inference]

negative regulation of B cell receptor signaling pathway

regulation of antigen receptor-mediated signaling pathway [inference]

regulation of B cell receptor signaling pathway [inference]

negative regulation of B cell receptor signaling pathway

negative regulation of antigen receptor-mediated signaling pathway [inference]

negative regulation of B cell receptor signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of antigen receptor-mediated signaling pathway [inference]

negative regulation of B cell receptor signaling pathway

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic transmission, GABAergic

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of antigen receptor-mediated signaling pathway [inference]

negative regulation of B cell receptor signaling pathway

negative regulation of sequestering of calcium ion [inference]

release of sequestered calcium ion into cytosol

regulation of sequestering of calcium ion [inference]

negative regulation of sequestering of calcium ion [inference]

release of sequestered calcium ion into cytosol

regulation of multicellular organismal process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of cold-induced thermogenesis

regulation of cold-induced thermogenesis [inference]

negative regulation of cold-induced thermogenesis

Displaying 1 entry
GO Term	Evidence Code	PMID
cytoplasm	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

Displaying **all 4** entries
GO Term	Evidence Code	PMID
phosphatidylinositol phospholipase C activity	IBA
protein binding	IPI	15231748 28514442 32814053 33961781
GABA receptor binding	IDA	16754670
inositol 1,4,5 trisphosphate binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

lipase activity [inference]

phospholipase activity [inference]

phospholipase C activity [inference]

phosphatidylinositol phospholipase C activity

phosphoric ester hydrolase activity [inference]

phosphoric diester hydrolase activity [inference]

phospholipase C activity [inference]

phosphatidylinositol phospholipase C activity

binding [inference]

protein binding

signaling receptor binding [inference]

GABA receptor binding

small molecule binding [inference]

alcohol binding [inference]

inositol 1,4,5 trisphosphate binding

ion binding [inference]

anion binding [inference]

inositol 1,4,5 trisphosphate binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Phospholipase C

Functional Category

J: Translation, ribosomal structure and biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
hydrolase activity
lipid metabolic process
phosphatidylinositol phospholipase C activity
phosphatidylinositol-mediated signaling
release of sequestered calcium ion into cytosol

Displaying **all 10** entries
InterPro
C2 domain superfamily
C2 domain
EF-hand domain pair
PH-like domain superfamily
PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily
Phosphatidylinositol-specific phospholipase C, X domain
Phosphoinositide phospholipase C family
Phosphoinositide-specific phospholipase C, EF-hand-like domain
Phospholipase C, phosphatidylinositol-specific, Y domain
Pleckstrin homology domain

Ortholog

Displaying entries **1 - 10** of **107** in total

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Species	Gene ID	Alliance of Genome Resources
Saccharomyces cerevisiae S288C	5330	SGD:S000006189
Saccharomyces cerevisiae S288C	5331	SGD:S000006189
Saccharomyces cerevisiae S288C	5332	SGD:S000006189
Saccharomyces cerevisiae S288C	5333	SGD:S000006189
Saccharomyces cerevisiae S288C	5334	SGD:S000006189
Saccharomyces cerevisiae S288C	5335	SGD:S000006189
Saccharomyces cerevisiae S288C	5336	SGD:S000006189
Saccharomyces cerevisiae S288C	9651	SGD:S000006189
Saccharomyces cerevisiae S288C	18797	SGD:S000006189
Saccharomyces cerevisiae S288C	18799	SGD:S000006189

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Acknowledgements