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C-type lectin domain family 12, member a

Summary

Gene Symbol

Clec12a

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

232413

PubChem

232413

Alliance of Genome Resources

MGI:3040968

Annotation

Keyword

Cell membrane
Disulfide bond
Glycoprotein
Lectin
Proteomics identification
Receptor
Reference proteome
Signal-anchor
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q504P2	C-type lectin-like molecule 1 Myeloid inhibitory C-type lectin-like receptor
A0A0R4J0T2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
signal transduction	IBA
positive regulation of type I interferon production	IMP	31451663
negative regulation of natural killer cell activation	ISS
negative regulation of natural killer cell activation	IMP	31269448
negative regulation of inflammatory response	IDA	24631154

GO Hierarchy

biological process

cellular process [inference]

signal transduction

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of natural killer cell activation

negative regulation of neutrophil activation

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of dendritic cell differentiation

regulation of leukocyte activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of natural killer cell activation

negative regulation of neutrophil activation

regulation of lymphocyte activation [inference]

regulation of natural killer cell activation [inference]

negative regulation of natural killer cell activation

negative regulation of lymphocyte activation [inference]

negative regulation of natural killer cell activation

regulation of neutrophil activation [inference]

negative regulation of neutrophil activation

regulation of immune response

regulation of hemopoiesis [inference]

regulation of leukocyte differentiation [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of dendritic cell differentiation

regulation of dendritic cell differentiation [inference]

negative regulation of dendritic cell differentiation

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of dendritic cell differentiation

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production

regulation of type I interferon production [inference]

positive regulation of type I interferon production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production

regulation of type I interferon production [inference]

positive regulation of type I interferon production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production

regulation of type I interferon production [inference]

positive regulation of type I interferon production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of natural killer cell activation

negative regulation of neutrophil activation

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of dendritic cell differentiation

negative regulation of cellular process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of dendritic cell differentiation

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of natural killer cell activation

negative regulation of neutrophil activation

negative regulation of response to stimulus [inference]

negative regulation of defense response [inference]

negative regulation of inflammatory response

negative regulation of response to external stimulus [inference]

negative regulation of inflammatory response

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of dendritic cell differentiation

negative regulation of multicellular organismal process [inference]

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of natural killer cell activation

negative regulation of neutrophil activation

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of dendritic cell differentiation

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of inflammatory response

regulation of inflammatory response [inference]

negative regulation of inflammatory response

negative regulation of response to stimulus [inference]

negative regulation of defense response [inference]

negative regulation of inflammatory response

negative regulation of response to external stimulus [inference]

negative regulation of inflammatory response

regulation of immune response

regulation of response to stress [inference]

regulation of defense response [inference]

negative regulation of defense response [inference]

negative regulation of inflammatory response

regulation of inflammatory response [inference]

negative regulation of inflammatory response

regulation of developmental process [inference]

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of dendritic cell differentiation

regulation of cell development [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of dendritic cell differentiation

regulation of hemopoiesis [inference]

regulation of leukocyte differentiation [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of dendritic cell differentiation

regulation of dendritic cell differentiation [inference]

negative regulation of dendritic cell differentiation

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of dendritic cell differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of dendritic cell differentiation

regulation of multicellular organismal development [inference]

regulation of hemopoiesis [inference]

regulation of leukocyte differentiation [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of dendritic cell differentiation

regulation of dendritic cell differentiation [inference]

negative regulation of dendritic cell differentiation

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of dendritic cell differentiation

regulation of cellular process [inference]

signal transduction

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production

regulation of type I interferon production [inference]

positive regulation of type I interferon production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of dendritic cell differentiation

regulation of cell development [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of dendritic cell differentiation

regulation of hemopoiesis [inference]

regulation of leukocyte differentiation [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of dendritic cell differentiation

regulation of dendritic cell differentiation [inference]

negative regulation of dendritic cell differentiation

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of dendritic cell differentiation

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production

negative regulation of cellular process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of dendritic cell differentiation

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of natural killer cell activation

negative regulation of neutrophil activation

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of natural killer cell activation

negative regulation of neutrophil activation

regulation of lymphocyte activation [inference]

regulation of natural killer cell activation [inference]

negative regulation of natural killer cell activation

negative regulation of lymphocyte activation [inference]

negative regulation of natural killer cell activation

regulation of neutrophil activation [inference]

negative regulation of neutrophil activation

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of natural killer cell activation

negative regulation of neutrophil activation

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production

regulation of type I interferon production [inference]

positive regulation of type I interferon production

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of natural killer cell activation

negative regulation of neutrophil activation

regulation of lymphocyte activation [inference]

regulation of natural killer cell activation [inference]

negative regulation of natural killer cell activation

negative regulation of lymphocyte activation [inference]

negative regulation of natural killer cell activation

regulation of neutrophil activation [inference]

negative regulation of neutrophil activation

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of natural killer cell activation

negative regulation of neutrophil activation

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production

negative regulation of multicellular organismal process [inference]

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of natural killer cell activation

negative regulation of neutrophil activation

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of dendritic cell differentiation

regulation of multicellular organismal development [inference]

regulation of hemopoiesis [inference]

regulation of leukocyte differentiation [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of dendritic cell differentiation

regulation of dendritic cell differentiation [inference]

negative regulation of dendritic cell differentiation

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of dendritic cell differentiation

Displaying **all 3** entries
GO Term	Evidence Code	PMID
plasma membrane	IDA	34638548
plasma membrane	IBA
cell surface	ISO	14739280

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cell surface

membrane [inference]

plasma membrane

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
transmembrane signaling receptor activity	ISS
transmembrane signaling receptor activity	IDA	24631154 31451663 39143217
transmembrane signaling receptor activity	IBA
protein phosphatase binding	ISO	14739280
carbohydrate binding	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

enzyme binding [inference]

phosphatase binding [inference]

protein phosphatase binding

carbohydrate binding

molecular transducer activity [inference]

signaling receptor activity [inference]

molecular function regulator activity [inference]

signaling receptor regulator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

C-type lectin domain family 12 member A

Functional Category

I: Lipid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying 1 entry
Gene Ontology
signaling receptor regulator activity

Displaying **all 5** entries
InterPro
C-type lectin domain family 12 member A/B
C-type lectin fold
C-type lectin-like/link domain superfamily
C-type lectin-like
Natural killer cell receptor-like, C-type lectin-like domain

Ortholog

Displaying entries **1 - 10** of 38 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	160364	HGNC:31713	HUMAN11116
Homo sapiens	232413	HGNC:31713
Canis lupus familiaris	477697		CANLF11081
Bos taurus	508740		BOVIN30288
Rattus norvegicus	680338		RATNO31475
Macaca mulatta	722319		MACMU03851
Pan troglodytes	737508		PANTR05142
Equus caballus	100053711		HORSE37719
Callithrix jacchus	100403093		CALJA44465
Pongo abelii	100454834		PONAB05329

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements