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diphosphoinositol pentakisphosphate kinase 2

Summary

Gene Symbol

PPIP5K2

Organism

Homo sapiens (human)

External Links

NCBI Gene

23262

PubChem

23262

Alliance of Genome Resources

HGNC:29035

Annotation

Keyword

3D-structure
ATP-binding
Alternative splicing
Cytoplasm
Disease variant
Hearing
Kinase
Non-syndromic deafness
Phosphoprotein
Proteomics identification
Reference proteome

Proteins

Displaying **all 4** entries
UniProt	Protein Name
B4DGV1
O43314	Diphosphoinositol pentakisphosphate kinase 2 Histidine acid phosphatase domain-containing protein 1 InsP6 and PP-IP5 kinase 2 VIP1 homolog 2
A0A087WZV0
A0A8V8TMN4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
inositol metabolic process	ISS
inositol metabolic process	IBA
sensory perception of sound	IEA
inositol phosphate biosynthetic process	IBA
inositol phosphate metabolic process	TAS

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

inositol phosphate biosynthetic process

organic substance biosynthetic process [inference]

organophosphate biosynthetic process [inference]

inositol phosphate biosynthetic process

organic hydroxy compound biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

inositol phosphate biosynthetic process

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

inositol phosphate metabolic process

inositol phosphate biosynthetic process

organophosphate metabolic process [inference]

inositol phosphate metabolic process

inositol phosphate biosynthetic process

organophosphate biosynthetic process [inference]

inositol phosphate biosynthetic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

inositol metabolic process

inositol phosphate metabolic process

inositol phosphate biosynthetic process

polyol biosynthetic process [inference]

inositol phosphate biosynthetic process

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

inositol phosphate biosynthetic process

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

inositol phosphate biosynthetic process

organic substance metabolic process [inference]

organophosphate metabolic process [inference]

inositol phosphate metabolic process

inositol phosphate biosynthetic process

organophosphate biosynthetic process [inference]

inositol phosphate biosynthetic process

organic substance biosynthetic process [inference]

organophosphate biosynthetic process [inference]

inositol phosphate biosynthetic process

organic hydroxy compound biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

inositol phosphate biosynthetic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

inositol metabolic process

inositol phosphate metabolic process

inositol phosphate biosynthetic process

polyol biosynthetic process [inference]

inositol phosphate biosynthetic process

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

inositol phosphate biosynthetic process

organic hydroxy compound biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

inositol phosphate biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

inositol phosphate metabolic process

inositol phosphate biosynthetic process

organophosphate metabolic process [inference]

inositol phosphate metabolic process

inositol phosphate biosynthetic process

organophosphate biosynthetic process [inference]

inositol phosphate biosynthetic process

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of mechanical stimulus [inference]

sensory perception of sound

Displaying **all 4** entries
GO Term	Evidence Code	PMID
cytosol	ISS
cytosol	TAS
cytosol	IDA	17690096
cytosol	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
inositol-1,3,4,5,6-pentakisphosphate kinase activity	ISS
inositol hexakisphosphate kinase activity	TAS
inositol hexakisphosphate kinase activity	IDA	17690096
inositol hexakisphosphate kinase activity	IBA
inositol heptakisphosphate kinase activity	TAS

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

inositol-1,3,4,5,6-pentakisphosphate kinase activity

inositol hexakisphosphate kinase activity

phosphotransferase activity, phosphate group as acceptor [inference]

inositol-1,3,4,5,6-pentakisphosphate kinase activity

inositol hexakisphosphate kinase activity

inositol heptakisphosphate kinase activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate Kinase

Functional Category

M: Cell wall/membrane/envelope biogenesis
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying entries **1 - 10** of 13 in total

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Gene Ontology
ATP binding
inositol heptakisphosphate kinase activity
inositol hexakisphosphate 1-kinase activity
inositol hexakisphosphate 3-kinase activity
inositol hexakisphosphate 5-kinase activity
inositol hexakisphosphate kinase activity
inositol metabolic process
inositol phosphate biosynthetic process
inositol-1,3,4,5,6-pentakisphosphate kinase activity
kinase activity

Displaying **all 5** entries
InterPro
Histidine acid phosphatase active site
Histidine acid phosphatase, VIP1 family
Histidine phosphatase superfamily, clade-2
Histidine phosphatase superfamily
VIP1, N-terminal

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0111638	autosomal recessive nonsyndromic deafness 100	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 73 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	23262	Xenbase:XB-GENE-1000378
Mus musculus	227399		MOUSE30087
Danio rerio	449862		DANRE00155
Pan troglodytes	461976		PANTR35862
Canis lupus familiaris	488883		CANLF11849
Rattus norvegicus	501194		RATNO43063
Macaca mulatta	703458		MACMU39322
Bos taurus	780855		BOVIN34049
Monodelphis domestica	100030703		MONDO16918
Equus caballus	100064726		HORSE08203

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Acknowledgements