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Rho GTPase activating protein 35

Summary

Gene Symbol

Arhgap35

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

232906

PubChem

232906

Alliance of Genome Resources

MGI:1929494

Annotation

Keyword

Cell membrane
Cell projection
Coiled coil
Cytoskeleton
DNA-binding
GTP-binding
GTPase activation
Lipid-binding
Nucleus
Phosphoprotein
Receptor
Reference proteome
Repeat
Repressor
Transcription regulation

Proteins

Displaying **all 4** entries
UniProt	Protein Name
Q8CCL8
Q91YM2	Glucocorticoid receptor DNA-binding factor 1
B2RTN5	Glucocorticoid receptor DNA-binding factor 1
Q3UVZ8

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 27 in total

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GO Term	Evidence Code	PMID
neural tube closure	IMP	11044403
integrin-mediated signaling pathway	TAS	11044403
Rho protein signal transduction	IGI	23595732
Rho protein signal transduction	IBA
axon guidance	IDA	11283609

GO Hierarchy

biological process

cellular process [inference]

establishment or maintenance of cell polarity [inference]

establishment or maintenance of cytoskeleton polarity [inference]

establishment or maintenance of actin cytoskeleton polarity

signal transduction [inference]

cell surface receptor signaling pathway [inference]

integrin-mediated signaling pathway

intracellular signal transduction [inference]

small GTPase mediated signal transduction [inference]

Ras protein signal transduction [inference]

Rho protein signal transduction

cell recognition [inference]

neuron recognition [inference]

axonal fasciculation

actin filament-based process [inference]

actin cytoskeleton organization [inference]

establishment or maintenance of actin cytoskeleton polarity

cell motility [inference]

cell migration

wound healing, spreading of cells

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

actin cytoskeleton organization [inference]

establishment or maintenance of actin cytoskeleton polarity

establishment or maintenance of cytoskeleton polarity [inference]

establishment or maintenance of actin cytoskeleton polarity

cell projection organization [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

axonogenesis [inference]

central nervous system neuron axonogenesis

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance

axon guidance

neuron projection fasciculation [inference]

axonal fasciculation

regulation of cellular component size [inference]

regulation of cell size

regulation of actin filament length [inference]

regulation of actin polymerization or depolymerization

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

regulation of vascular permeability [inference]

negative regulation of vascular permeability

developmental process [inference]

anatomical structure morphogenesis [inference]

cellular anatomical entity morphogenesis [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

axonogenesis [inference]

central nervous system neuron axonogenesis

anatomical structure formation involved in morphogenesis [inference]

tube formation [inference]

tube closure [inference]

neural tube closure

anatomical structure development [inference]

forebrain development

animal organ development [inference]

sensory organ development [inference]

eye development [inference]

camera-type eye development

gland development [inference]

mammary gland development

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of small GTPase mediated signal transduction [inference]

negative regulation of Ras protein signal transduction [inference]

negative regulation of Rho protein signal transduction

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction [inference]

regulation of Ras protein signal transduction [inference]

regulation of Rho protein signal transduction [inference]

negative regulation of Rho protein signal transduction

negative regulation of Ras protein signal transduction [inference]

negative regulation of Rho protein signal transduction

negative regulation of small GTPase mediated signal transduction [inference]

negative regulation of Ras protein signal transduction [inference]

negative regulation of Rho protein signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of small GTPase mediated signal transduction [inference]

negative regulation of Ras protein signal transduction [inference]

negative regulation of Rho protein signal transduction

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of small GTPase mediated signal transduction [inference]

negative regulation of Ras protein signal transduction [inference]

negative regulation of Rho protein signal transduction

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of cilium assembly

positive regulation of organelle assembly [inference]

positive regulation of cilium assembly

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of organelle assembly [inference]

positive regulation of cilium assembly

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of cilium assembly

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of small GTPase mediated signal transduction [inference]

negative regulation of Ras protein signal transduction [inference]

negative regulation of Rho protein signal transduction

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of small GTPase mediated signal transduction [inference]

negative regulation of Ras protein signal transduction [inference]

negative regulation of Rho protein signal transduction

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of small GTPase mediated signal transduction [inference]

negative regulation of Ras protein signal transduction [inference]

negative regulation of Rho protein signal transduction

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of small GTPase mediated signal transduction [inference]

negative regulation of Ras protein signal transduction [inference]

negative regulation of Rho protein signal transduction

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction [inference]

regulation of Ras protein signal transduction [inference]

regulation of Rho protein signal transduction [inference]

negative regulation of Rho protein signal transduction

negative regulation of Ras protein signal transduction [inference]

negative regulation of Rho protein signal transduction

negative regulation of small GTPase mediated signal transduction [inference]

negative regulation of Ras protein signal transduction [inference]

negative regulation of Rho protein signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of small GTPase mediated signal transduction [inference]

negative regulation of Ras protein signal transduction [inference]

negative regulation of Rho protein signal transduction

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of small GTPase mediated signal transduction [inference]

negative regulation of Ras protein signal transduction [inference]

negative regulation of Rho protein signal transduction

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of cell morphogenesis [inference]

regulation of cell shape

regulation of axonogenesis

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

integrin-mediated signaling pathway

intracellular signal transduction [inference]

small GTPase mediated signal transduction [inference]

Ras protein signal transduction [inference]

Rho protein signal transduction

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of small GTPase mediated signal transduction [inference]

negative regulation of Ras protein signal transduction [inference]

negative regulation of Rho protein signal transduction

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction [inference]

regulation of Ras protein signal transduction [inference]

regulation of Rho protein signal transduction [inference]

negative regulation of Rho protein signal transduction

negative regulation of Ras protein signal transduction [inference]

negative regulation of Rho protein signal transduction

negative regulation of small GTPase mediated signal transduction [inference]

negative regulation of Ras protein signal transduction [inference]

negative regulation of Rho protein signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of small GTPase mediated signal transduction [inference]

negative regulation of Ras protein signal transduction [inference]

negative regulation of Rho protein signal transduction

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of small GTPase mediated signal transduction [inference]

negative regulation of Ras protein signal transduction [inference]

negative regulation of Rho protein signal transduction

regulation of actin filament-based process [inference]

regulation of actin cytoskeleton organization

regulation of actin filament length [inference]

regulation of actin polymerization or depolymerization

regulation of actin filament organization [inference]

regulation of actin polymerization or depolymerization

regulation of cellular component biogenesis [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of cilium assembly

positive regulation of organelle assembly [inference]

positive regulation of cilium assembly

regulation of cell projection assembly [inference]

regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of cilium assembly

regulation of cilium assembly [inference]

positive regulation of cilium assembly

regulation of organelle assembly [inference]

regulation of cilium assembly [inference]

positive regulation of cilium assembly

positive regulation of organelle assembly [inference]

positive regulation of cilium assembly

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of cilium assembly

positive regulation of organelle assembly [inference]

positive regulation of cilium assembly

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of organelle assembly [inference]

positive regulation of cilium assembly

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of cilium assembly

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of small GTPase mediated signal transduction [inference]

negative regulation of Ras protein signal transduction [inference]

negative regulation of Rho protein signal transduction

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of cilium assembly

regulation of cell projection assembly [inference]

regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of cilium assembly

regulation of cilium assembly [inference]

positive regulation of cilium assembly

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of cilium assembly

regulation of cilium assembly [inference]

positive regulation of cilium assembly

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of organelle assembly [inference]

positive regulation of cilium assembly

regulation of cytoskeleton organization [inference]

regulation of actin cytoskeleton organization

regulation of actin filament length [inference]

regulation of actin polymerization or depolymerization

regulation of actin filament organization [inference]

regulation of actin polymerization or depolymerization

regulation of organelle assembly [inference]

regulation of cilium assembly [inference]

positive regulation of cilium assembly

positive regulation of organelle assembly [inference]

positive regulation of cilium assembly

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of organelle assembly [inference]

positive regulation of cilium assembly

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of cilium assembly

regulation of supramolecular fiber organization [inference]

regulation of actin filament organization [inference]

regulation of actin polymerization or depolymerization

regulation of biological quality [inference]

regulation of cell shape

regulation of vascular permeability [inference]

negative regulation of vascular permeability

regulation of anatomical structure size [inference]

regulation of cellular component size [inference]

regulation of cell size

regulation of actin filament length [inference]

regulation of actin polymerization or depolymerization

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of GTPase activity

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of GTPase activity

regulation of hydrolase activity [inference]

regulation of GTPase activity [inference]

positive regulation of GTPase activity

positive regulation of hydrolase activity [inference]

positive regulation of GTPase activity

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
nucleus	IEA
cytoplasm	IDA	11044403
cytosol	IBA
plasma membrane	IEA
actin cytoskeleton	IDA	11044403

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

microtubule organizing center [inference]

ciliary basal body

cytosol

membrane [inference]

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

actin cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

actin cytoskeleton

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
DNA binding	IEA
GTPase activity	IEA
GTPase activator activity	ISS
GTPase activator activity	ISO
GTPase activator activity	TAS	11044403

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

GTPase activity

binding [inference]

protein binding [inference]

GTPase activating protein binding

lipid binding [inference]

phospholipid binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

GTP binding

protein-containing complex binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleoside triphosphate binding [inference]

GTP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

nucleoside-triphosphatase regulator activity [inference]

GTPase regulator activity [inference]

GTPase activator activity

molecular function activator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

rho GTPase-activating protein

Functional Category

O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
GTP binding
Rho protein signal transduction
nucleotide binding
regulation of axonogenesis
regulation of cell size

Displaying **all 10** entries
InterPro
FF domain superfamily
FF domain
P-loop containing nucleoside triphosphate hydrolase
Rho GTPase activation protein
Rho GTPase-activating protein domain
Rho GTPase-activating protein, FF domain
Rho GTPase-activating protein, pG1 and pG2 domain
Rho GTPase-activating protein, pG1 domain
Rho GTPase-activating protein, pG2 domain
Small GTPase

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements