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Guidelines

MIRAGE

SMG6 nonsense mediated mRNA decay factor

Summary

Gene Symbol

SMG6

Organism

Homo sapiens (human)

External Links

NCBI Gene

23293

KEGG Gene ID

PubChem

23293

Alliance of Genome Resources

HGNC:17809

Annotation

Keyword

3D-structure
Alternative splicing
Coiled coil
Cytoplasm
DNA-binding
Endonuclease
Manganese
Metal-binding
Methylation
Nonsense-mediated mRNA decay
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome
Telomere

Proteins

Displaying 1 entry
UniProt	Protein Name
Q86US8	Ever shorter telomeres 1A Nonsense mediated mRNA decay factor SMG6 Smg-6 homolog hSmg5/7a

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	TAS
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IMP
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IBA
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IEA
mRNA export from nucleus	TAS

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

catabolic process [inference]

macromolecule catabolic process [inference]

nucleic acid catabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

nucleobase-containing compound catabolic process [inference]

nucleic acid catabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

nucleic acid catabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

mRNA metabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

nucleic acid catabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleic acid catabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

mRNA metabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

nucleic acid catabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

intercellular transport [inference]

nuclear export [inference]

RNA export from nucleus [inference]

mRNA export from nucleus

cellular localization [inference]

intracellular transport [inference]

nuclear transport [inference]

nucleocytoplasmic transport [inference]

nuclear export [inference]

RNA export from nucleus [inference]

mRNA export from nucleus

localization [inference]

establishment of localization [inference]

transport [inference]

intercellular transport [inference]

nuclear export [inference]

RNA export from nucleus [inference]

mRNA export from nucleus

intracellular transport [inference]

nuclear transport [inference]

nucleocytoplasmic transport [inference]

nuclear export [inference]

RNA export from nucleus [inference]

mRNA export from nucleus

nitrogen compound transport [inference]

nucleobase-containing compound transport [inference]

nucleic acid transport [inference]

RNA transport [inference]

RNA export from nucleus [inference]

mRNA export from nucleus

mRNA transport [inference]

mRNA export from nucleus

establishment of RNA localization [inference]

RNA transport [inference]

RNA export from nucleus [inference]

mRNA export from nucleus

mRNA transport [inference]

mRNA export from nucleus

establishment of localization in cell [inference]

intracellular transport [inference]

nuclear transport [inference]

nucleocytoplasmic transport [inference]

nuclear export [inference]

RNA export from nucleus [inference]

mRNA export from nucleus

cellular localization [inference]

intracellular transport [inference]

nuclear transport [inference]

nucleocytoplasmic transport [inference]

nuclear export [inference]

RNA export from nucleus [inference]

mRNA export from nucleus

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of chromosome organization [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

regulation of DNA biosynthetic process [inference]

regulation of telomere maintenance via telomerase

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping

regulation of dephosphorylation

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

regulation of DNA biosynthetic process [inference]

regulation of telomere maintenance via telomerase

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping

regulation of DNA metabolic process [inference]

regulation of telomere maintenance

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping

regulation of telomere capping [inference]

negative regulation of telomere capping

regulation of telomere maintenance via telomere lengthening [inference]

regulation of telomere maintenance via telomerase

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping

regulation of DNA biosynthetic process [inference]

regulation of telomere maintenance via telomerase

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping

regulation of DNA metabolic process [inference]

regulation of telomere maintenance

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping

regulation of telomere capping [inference]

negative regulation of telomere capping

regulation of telomere maintenance via telomere lengthening [inference]

regulation of telomere maintenance via telomerase

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping

regulation of DNA biosynthetic process [inference]

regulation of telomere maintenance via telomerase

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of chromosome organization [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

negative regulation of organelle organization [inference]

negative regulation of chromosome organization [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping

regulation of chromosome organization [inference]

regulation of telomere maintenance

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping

regulation of telomere capping [inference]

negative regulation of telomere capping

regulation of telomere maintenance via telomere lengthening [inference]

regulation of telomere maintenance via telomerase

negative regulation of chromosome organization [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of chromosome organization [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
chromosome, telomeric region	IEA
nucleus	IDA
telomerase holoenzyme complex	TAS
telomerase holoenzyme complex	IBA
nucleolus	IDA

GO Hierarchy

cellular component

protein-containing complex [inference]

nuclear protein-containing complex [inference]

catalytic complex [inference]

telomerase holoenzyme complex

ribonucleoprotein complex [inference]

telomerase holoenzyme complex

cellular anatomical structure [inference]

cytoplasm

microtubule organizing center [inference]

ciliary basal body

cytosol

membrane [inference]

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

membraneless organelle [inference]

intracellular membraneless organelle [inference]

nucleolus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular membraneless organelle [inference]

nucleolus

chromosomal region [inference]

chromosome, telomeric region

Displaying entries **11 - 13** of 13 in total

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GO Term	Evidence Code	PMID
telomerase RNA binding	IBA
telomerase RNA binding	IPI
DNA polymerase binding	IPI

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity

catalytic activity, acting on a nucleic acid [inference]

nuclease activity [inference]

endonuclease activity [inference]

RNA endonuclease activity

RNA nuclease activity [inference]

RNA endonuclease activity

catalytic activity, acting on RNA [inference]

RNA nuclease activity [inference]

RNA endonuclease activity

binding [inference]

nucleic acid binding [inference]

DNA binding [inference]

sequence-specific DNA binding [inference]

telomeric repeat DNA binding

telomerase RNA binding

protein binding

enzyme binding [inference]

DNA polymerase binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

protein-containing complex binding [inference]

ribonucleoprotein complex binding

Gene Ontology information from NCBI Gene and UniProt.

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026