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cytoplasmic linker associated protein 1

Summary

Gene Symbol

CLASP1

Organism

Homo sapiens (human)

External Links

NCBI Gene

23332

PubChem

23332

Alliance of Genome Resources

HGNC:17088

JoGo

CLASP1

TogoVar

CLASP1

Annotation

Keyword

3D-structure
Alternative splicing
Centromere
Chromosome
Coiled coil
Cytoskeleton
Golgi apparatus
Kinetochore
Microtubule
Mitosis
Phosphoprotein
Proteomics identification
Reference proteome
Repeat

Proteins

Displaying **all 3** entries
UniProt	Protein Name
A0A8V8TRF6	Cytoplasmic linker-associated protein 1
A0A8V8TLP7	Cytoplasmic linker-associated protein 1
Q7Z460	Cytoplasmic linker-associated protein 1 Multiple asters homolog 1 Protein Orbit homolog 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **21 - 25** of 36 in total

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GO Term	Evidence Code	PMID
establishment of mitotic spindle localization	IBA
positive regulation of exocytosis	IMP	24859005
establishment of spindle orientation	IDA	21822276
establishment of spindle orientation	IMP	21822276
establishment of spindle orientation	IGI	21822276

GO Hierarchy

biological process

cellular process [inference]

vesicle targeting

microtubule-based process [inference]

microtubule cytoskeleton organization

spindle organization [inference]

mitotic spindle organization

mitotic spindle assembly

astral microtubule organization

spindle assembly [inference]

mitotic spindle assembly

cytoplasmic microtubule organization [inference]

astral microtubule organization

microtubule anchoring

establishment of spindle localization [inference]

microtubule cytoskeleton organization involved in mitosis [inference]

mitotic spindle organization

mitotic spindle assembly

establishment of mitotic spindle localization

microtubule organizing center organization

establishment or maintenance of cell polarity

establishment of cell polarity [inference]

establishment of epithelial cell polarity

cell cycle process [inference]

spindle organization [inference]

mitotic spindle organization

mitotic spindle assembly

astral microtubule organization

spindle assembly [inference]

mitotic spindle assembly

cell cycle phase transition [inference]

mitotic cell cycle phase transition [inference]

exit from mitosis

spindle localization [inference]

establishment of spindle localization [inference]

mitotic cell cycle process [inference]

mitotic cell cycle phase transition [inference]

exit from mitosis

microtubule cytoskeleton organization involved in mitosis [inference]

mitotic spindle organization

mitotic spindle assembly

establishment of mitotic spindle localization

cell division

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

microtubule cytoskeleton organization

spindle organization [inference]

mitotic spindle organization

mitotic spindle assembly

astral microtubule organization

spindle assembly [inference]

mitotic spindle assembly

cytoplasmic microtubule organization [inference]

astral microtubule organization

microtubule anchoring

establishment of spindle localization [inference]

microtubule cytoskeleton organization involved in mitosis [inference]

mitotic spindle organization

mitotic spindle assembly

establishment of mitotic spindle localization

Golgi organization

organelle assembly [inference]

non-membrane-bounded organelle assembly [inference]

spindle assembly [inference]

mitotic spindle assembly

cellular component assembly [inference]

organelle assembly [inference]

non-membrane-bounded organelle assembly [inference]

spindle assembly [inference]

mitotic spindle assembly

microtubule organizing center organization

supramolecular fiber organization [inference]

cytoplasmic microtubule organization [inference]

astral microtubule organization

localization [inference]

establishment of localization [inference]

establishment of localization in cell [inference]

establishment of spindle localization [inference]

establishment of organelle localization [inference]

establishment of spindle localization [inference]

organelle localization [inference]

spindle localization [inference]

establishment of spindle localization [inference]

establishment of organelle localization [inference]

establishment of spindle localization [inference]

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of exocytosis

regulation of secretion by cell [inference]

regulation of exocytosis [inference]

positive regulation of exocytosis

positive regulation of secretion by cell [inference]

positive regulation of exocytosis

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of exocytosis

regulation of vesicle-mediated transport [inference]

regulation of exocytosis [inference]

positive regulation of exocytosis

regulation of locomotion [inference]

negative regulation of locomotion [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of wound healing, spreading of epidermal cells

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of epithelial cell migration [inference]

positive regulation of epithelial cell migration

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration

negative regulation of cell migration [inference]

negative regulation of wound healing, spreading of epidermal cells

regulation of wound healing, spreading of epidermal cells [inference]

negative regulation of wound healing, spreading of epidermal cells

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of wound healing, spreading of epidermal cells

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration

positive regulation of biological process [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of microtubule polymerization

positive regulation of extracellular matrix assembly [inference]

positive regulation of basement membrane assembly involved in embryonic body morphogenesis

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule polymerization

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of microtubule polymerization

positive regulation of supramolecular fiber organization [inference]

positive regulation of microtubule polymerization

positive regulation of extracellular matrix organization [inference]

positive regulation of extracellular matrix disassembly

positive regulation of extracellular matrix assembly [inference]

positive regulation of basement membrane assembly involved in embryonic body morphogenesis

positive regulation of secretion by cell [inference]

positive regulation of exocytosis

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of exocytosis

positive regulation of developmental process [inference]

positive regulation of basement membrane assembly involved in embryonic body morphogenesis

negative regulation of biological process [inference]

negative regulation of locomotion [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of wound healing, spreading of epidermal cells

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of microtubule polymerization or depolymerization

negative regulation of microtubule depolymerization

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

negative regulation of protein-containing complex disassembly [inference]

negative regulation of protein depolymerization [inference]

negative regulation of microtubule depolymerization

negative regulation of supramolecular fiber organization [inference]

negative regulation of microtubule depolymerization

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of wound healing, spreading of epidermal cells

negative regulation of response to stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of wound healing [inference]

negative regulation of wound healing, spreading of epidermal cells

negative regulation of response to wounding [inference]

negative regulation of wound healing [inference]

negative regulation of wound healing, spreading of epidermal cells

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of wound healing [inference]

negative regulation of wound healing, spreading of epidermal cells

negative regulation of response to stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of wound healing [inference]

negative regulation of wound healing, spreading of epidermal cells

negative regulation of response to wounding [inference]

negative regulation of wound healing [inference]

negative regulation of wound healing, spreading of epidermal cells

regulation of response to stress [inference]

regulation of response to wounding [inference]

regulation of wound healing [inference]

negative regulation of wound healing [inference]

negative regulation of wound healing, spreading of epidermal cells

regulation of wound healing, spreading of epidermal cells [inference]

negative regulation of wound healing, spreading of epidermal cells

negative regulation of response to wounding [inference]

negative regulation of wound healing [inference]

negative regulation of wound healing, spreading of epidermal cells

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of gastrulation

regulation of cell differentiation [inference]

regulation of epithelial to mesenchymal transition

positive regulation of developmental process [inference]

positive regulation of basement membrane assembly involved in embryonic body morphogenesis

regulation of multicellular organismal development [inference]

regulation of embryonic development [inference]

regulation of gastrulation

regulation of basement membrane assembly involved in embryonic body morphogenesis [inference]

positive regulation of basement membrane assembly involved in embryonic body morphogenesis

regulation of cellular process [inference]

regulation of cell adhesion [inference]

regulation of cell-substrate adhesion [inference]

regulation of cell-matrix adhesion [inference]

regulation of focal adhesion assembly

regulation of microtubule-based process [inference]

regulation of microtubule cytoskeleton organization

regulation of microtubule polymerization or depolymerization [inference]

negative regulation of microtubule polymerization or depolymerization

negative regulation of microtubule depolymerization

positive regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule polymerization

regulation of microtubule polymerization [inference]

positive regulation of microtubule polymerization

regulation of microtubule depolymerization [inference]

negative regulation of microtubule depolymerization

regulation of actin filament-based process [inference]

regulation of actin cytoskeleton organization [inference]

regulation of actomyosin structure organization [inference]

regulation of stress fiber assembly [inference]

negative regulation of stress fiber assembly

regulation of actin filament organization [inference]

regulation of actin filament bundle assembly [inference]

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

regulation of stress fiber assembly [inference]

negative regulation of stress fiber assembly

regulation of cellular component biogenesis [inference]

regulation of actin filament bundle assembly [inference]

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

regulation of stress fiber assembly [inference]

negative regulation of stress fiber assembly

regulation of protein-containing complex assembly [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of microtubule polymerization

regulation of protein polymerization [inference]

regulation of microtubule polymerization [inference]

positive regulation of microtubule polymerization

positive regulation of protein polymerization [inference]

positive regulation of microtubule polymerization

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of microtubule polymerization

positive regulation of extracellular matrix assembly [inference]

positive regulation of basement membrane assembly involved in embryonic body morphogenesis

regulation of extracellular matrix assembly [inference]

positive regulation of extracellular matrix assembly [inference]

positive regulation of basement membrane assembly involved in embryonic body morphogenesis

regulation of basement membrane assembly involved in embryonic body morphogenesis [inference]

positive regulation of basement membrane assembly involved in embryonic body morphogenesis

regulation of cell junction assembly [inference]

regulation of cell-substrate junction assembly [inference]

regulation of focal adhesion assembly

regulation of cell differentiation [inference]

regulation of epithelial to mesenchymal transition

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of microtubule polymerization

positive regulation of extracellular matrix assembly [inference]

positive regulation of basement membrane assembly involved in embryonic body morphogenesis

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule polymerization

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of microtubule polymerization

positive regulation of supramolecular fiber organization [inference]

positive regulation of microtubule polymerization

positive regulation of extracellular matrix organization [inference]

positive regulation of extracellular matrix disassembly

positive regulation of extracellular matrix assembly [inference]

positive regulation of basement membrane assembly involved in embryonic body morphogenesis

positive regulation of secretion by cell [inference]

positive regulation of exocytosis

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of microtubule polymerization or depolymerization

negative regulation of microtubule depolymerization

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

negative regulation of protein-containing complex disassembly [inference]

negative regulation of protein depolymerization [inference]

negative regulation of microtubule depolymerization

negative regulation of supramolecular fiber organization [inference]

negative regulation of microtubule depolymerization

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of wound healing, spreading of epidermal cells

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule polymerization

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of microtubule polymerization or depolymerization

negative regulation of microtubule depolymerization

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

regulation of cytoskeleton organization [inference]

regulation of actin cytoskeleton organization [inference]

regulation of actomyosin structure organization [inference]

regulation of stress fiber assembly [inference]

negative regulation of stress fiber assembly

regulation of actin filament organization [inference]

regulation of actin filament bundle assembly [inference]

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

regulation of stress fiber assembly [inference]

negative regulation of stress fiber assembly

negative regulation of cytoskeleton organization [inference]

negative regulation of microtubule polymerization or depolymerization

negative regulation of microtubule depolymerization

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

positive regulation of cytoskeleton organization [inference]

positive regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule polymerization

regulation of microtubule cytoskeleton organization

regulation of microtubule polymerization or depolymerization [inference]

negative regulation of microtubule polymerization or depolymerization

negative regulation of microtubule depolymerization

positive regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule polymerization

regulation of microtubule polymerization [inference]

positive regulation of microtubule polymerization

regulation of microtubule depolymerization [inference]

negative regulation of microtubule depolymerization

regulation of protein-containing complex disassembly [inference]

negative regulation of protein-containing complex disassembly [inference]

negative regulation of protein depolymerization [inference]

negative regulation of microtubule depolymerization

regulation of protein depolymerization [inference]

regulation of microtubule depolymerization [inference]

negative regulation of microtubule depolymerization

negative regulation of protein depolymerization [inference]

negative regulation of microtubule depolymerization

regulation of protein-containing complex assembly [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of microtubule polymerization

regulation of protein polymerization [inference]

regulation of microtubule polymerization [inference]

positive regulation of microtubule polymerization

positive regulation of protein polymerization [inference]

positive regulation of microtubule polymerization

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of microtubule polymerization or depolymerization

negative regulation of microtubule depolymerization

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

negative regulation of protein-containing complex disassembly [inference]

negative regulation of protein depolymerization [inference]

negative regulation of microtubule depolymerization

negative regulation of supramolecular fiber organization [inference]

negative regulation of microtubule depolymerization

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule polymerization

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of microtubule polymerization

positive regulation of supramolecular fiber organization [inference]

positive regulation of microtubule polymerization

positive regulation of extracellular matrix organization [inference]

positive regulation of extracellular matrix disassembly

positive regulation of extracellular matrix assembly [inference]

positive regulation of basement membrane assembly involved in embryonic body morphogenesis

regulation of cell-substrate junction organization [inference]

regulation of cell-substrate junction assembly [inference]

regulation of focal adhesion assembly

regulation of cell junction assembly [inference]

regulation of cell-substrate junction assembly [inference]

regulation of focal adhesion assembly

regulation of supramolecular fiber organization [inference]

regulation of microtubule polymerization [inference]

positive regulation of microtubule polymerization

regulation of microtubule depolymerization [inference]

negative regulation of microtubule depolymerization

regulation of actin filament organization [inference]

regulation of actin filament bundle assembly [inference]

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

regulation of stress fiber assembly [inference]

negative regulation of stress fiber assembly

negative regulation of supramolecular fiber organization [inference]

negative regulation of microtubule depolymerization

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

positive regulation of supramolecular fiber organization [inference]

positive regulation of microtubule polymerization

regulation of extracellular matrix organization [inference]

regulation of extracellular matrix disassembly [inference]

positive regulation of extracellular matrix disassembly

regulation of basement membrane organization [inference]

regulation of basement membrane assembly involved in embryonic body morphogenesis [inference]

positive regulation of basement membrane assembly involved in embryonic body morphogenesis

regulation of extracellular matrix assembly [inference]

positive regulation of extracellular matrix assembly [inference]

positive regulation of basement membrane assembly involved in embryonic body morphogenesis

regulation of basement membrane assembly involved in embryonic body morphogenesis [inference]

positive regulation of basement membrane assembly involved in embryonic body morphogenesis

positive regulation of extracellular matrix organization [inference]

positive regulation of extracellular matrix disassembly

positive regulation of extracellular matrix assembly [inference]

positive regulation of basement membrane assembly involved in embryonic body morphogenesis

regulation of vesicle-mediated transport [inference]

regulation of exocytosis [inference]

positive regulation of exocytosis

regulation of secretion by cell [inference]

regulation of exocytosis [inference]

positive regulation of exocytosis

positive regulation of secretion by cell [inference]

positive regulation of exocytosis

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of epithelial cell migration [inference]

positive regulation of epithelial cell migration

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration

negative regulation of cell migration [inference]

negative regulation of wound healing, spreading of epidermal cells

regulation of wound healing, spreading of epidermal cells [inference]

negative regulation of wound healing, spreading of epidermal cells

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of wound healing, spreading of epidermal cells

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration

regulation of multicellular organismal process [inference]

regulation of epithelial cell migration [inference]

positive regulation of epithelial cell migration

regulation of multicellular organismal development [inference]

regulation of embryonic development [inference]

regulation of gastrulation

regulation of basement membrane assembly involved in embryonic body morphogenesis [inference]

positive regulation of basement membrane assembly involved in embryonic body morphogenesis

Displaying entries **1 - 5** of 20 in total

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GO Term	Evidence Code	PMID
kinetochore	IDA	12837247
kinetochore	IBA
Golgi apparatus	IDA	15631994
centrosome	IDA	12837247 15631994 21399614
microtubule organizing center	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm [inference]

cell cortex

cell cortex region [inference]

basal cortex

cytoplasmic region [inference]

cell cortex region [inference]

basal cortex

microtubule organizing center

centrosome

cell junction [inference]

anchoring junction [inference]

cell-substrate junction [inference]

focal adhesion

centrosomal corona

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

kinetochore

spindle [inference]

mitotic spindle

cytoskeleton [inference]

cortical cytoskeleton [inference]

cortical microtubule cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular non-membrane-bounded organelle [inference]

kinetochore

spindle [inference]

mitotic spindle

cytoskeleton [inference]

cortical cytoskeleton [inference]

cortical microtubule cytoskeleton

supramolecular complex [inference]

kinetochore

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

microtubule [inference]

spindle microtubule

kinetochore microtubule

cytoplasmic microtubule

microtubule end [inference]

microtubule plus-end

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
dystroglycan binding	IPI	23940118
protein binding	IPI	11290329 15631994 17342765 17543864 20852589 21646404 25416956 32296183 33587225 35271311 36931259
microtubule binding	IDA	11290329
microtubule binding	IMP	12837247
microtubule binding	IBA