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Rho guanine nucleotide exchange factor 12

Summary

Gene Symbol

ARHGEF12

Organism

Homo sapiens (human)

External Links

NCBI Gene

23365

PubChem

23365

Alliance of Genome Resources

HGNC:14193

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Chromosomal rearrangement
Coiled coil
Cytoplasm
GTPase activation
Guanine-nucleotide releasing factor
Membrane
Phosphoprotein
Proteomics identification
Proto-oncogene
Reference proteome

Proteins

Displaying **all 3** entries
UniProt	Protein Name
E9PMR6
Q9NZN5	Leukemia-associated RhoGEF
B4E2K6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
G protein-coupled receptor signaling pathway	IDA	15755723
G protein-coupled receptor signaling pathway	IBA
Rho protein signal transduction	IEA
regulation of small GTPase mediated signal transduction	TAS

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

intracellular signal transduction [inference]

small GTPase mediated signal transduction [inference]

Ras protein signal transduction [inference]

Rho protein signal transduction

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

intracellular signal transduction [inference]

small GTPase mediated signal transduction [inference]

Ras protein signal transduction [inference]

Rho protein signal transduction

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction

Displaying **all 5** entries
GO Term	Evidence Code	PMID
cytoplasm	IDA	15755723
cytoplasm	IBA
cytosol	TAS
membrane	IEA
extracellular exosome	HDA	19056867

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
G protein-coupled receptor binding	IDA	15755723
G protein-coupled receptor binding	IBA
guanyl-nucleotide exchange factor activity	TAS
guanyl-nucleotide exchange factor activity	IDA	11094164
guanyl-nucleotide exchange factor activity	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

G protein-coupled receptor binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

nucleoside-triphosphatase regulator activity [inference]

GTPase regulator activity [inference]

molecular function activator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Rho guanine nucleotide exchange factor

Functional Category

K: Transcription
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 4** entries
InterPro
Citron homology (CNH) domain
Dbl homology (DH) domain superfamily
Dbl homology (DH) domain
PH-like domain superfamily

Ortholog

Displaying entries **1 - 10** of 86 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	9826	FB:FBgn0023172
Drosophila melanogaster	16801	FB:FBgn0023172
Xenopus tropicalis	23365	Xenbase:XB-GENE-485387
Mus musculus	69632		MOUSE62021
Rattus norvegicus	367072		RATNO40367
Pan troglodytes	451618		PANTR04573
Canis lupus familiaris	479409		CANLF15184
Bos taurus	503575		BOVIN06623
Danio rerio	562455		DANRE09659
Macaca mulatta	712096		MACMU09658