GlyCosmos Portal

crumbs cell polarity complex component 1

Summary

Gene Symbol

CRB1

Organism

Homo sapiens (human)

External Links

NCBI Gene

23418

PubChem

23418

Alliance of Genome Resources

HGNC:2343

Annotation

Keyword

3D-structure
Alternative splicing
Calcium
Cell membrane
Cell projection
Disease variant
Disulfide bond
EGF-like domain
Glycoprotein
Leber congenital amaurosis
Proteomics identification
Reference proteome
Repeat
Retinitis pigmentosa
Secreted
Signal
Transmembrane helix

Proteins

Displaying **all 6** entries
UniProt	Protein Name
F5H0L2
P82279
A8K118
A0A7D6VM04
B7Z826
B7Z824

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	PMID
blood vessel remodeling	IEA
plasma membrane organization	IEA
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IBA
establishment or maintenance of cell polarity	TAS	10508521
cell-cell signaling	TAS	10508521

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular process [inference]

cell communication [inference]

cell-cell signaling

cell adhesion [inference]

cell-cell adhesion [inference]

cell-cell adhesion via plasma-membrane adhesion molecules [inference]

heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules

establishment or maintenance of cell polarity

establishment of cell polarity [inference]

establishment of bipolar cell polarity [inference]

establishment of bipolar cell polarity involved in cell morphogenesis

establishment or maintenance of bipolar cell polarity [inference]

establishment or maintenance of apical/basal cell polarity [inference]

establishment or maintenance of epithelial cell apical/basal polarity

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular developmental process [inference]

cell differentiation [inference]

glial cell differentiation

cell development [inference]

neuron development [inference]

photoreceptor cell development [inference]

eye photoreceptor cell development

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization

cellular response to stimulus [inference]

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to light stimulus

cellular component organization or biogenesis [inference]

cellular component organization [inference]

photoreceptor cell outer segment organization

membrane organization [inference]

plasma membrane organization

multicellular organismal process [inference]

photoreceptor cell maintenance

tissue remodeling [inference]

blood vessel remodeling

developmental process [inference]

anatomical structure morphogenesis [inference]

post-embryonic animal morphogenesis [inference]

post-embryonic retina morphogenesis in camera-type eye

anatomical structure formation involved in morphogenesis [inference]

retina layer formation

anatomical structure development [inference]

cell development [inference]

neuron development [inference]

photoreceptor cell development [inference]

eye photoreceptor cell development

cellular developmental process [inference]

cell differentiation [inference]

glial cell differentiation

cell development [inference]

neuron development [inference]

photoreceptor cell development [inference]

eye photoreceptor cell development

response to stimulus [inference]

response to external stimulus [inference]

detection of external stimulus [inference]

detection of light stimulus [inference]

detection of visible light [inference]

detection of light stimulus involved in visual perception

detection of light stimulus involved in sensory perception [inference]

detection of light stimulus involved in visual perception

response to abiotic stimulus [inference]

response to radiation [inference]

response to light stimulus [inference]

detection of light stimulus [inference]

detection of visible light [inference]

detection of light stimulus involved in visual perception

detection of light stimulus involved in sensory perception [inference]

detection of light stimulus involved in visual perception

cellular response to light stimulus

cellular response to radiation [inference]

cellular response to light stimulus

detection of abiotic stimulus [inference]

detection of light stimulus [inference]

detection of visible light [inference]

detection of light stimulus involved in visual perception

detection of light stimulus involved in sensory perception [inference]

detection of light stimulus involved in visual perception

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to light stimulus

detection of stimulus [inference]

detection of external stimulus [inference]

detection of light stimulus [inference]

detection of visible light [inference]

detection of light stimulus involved in visual perception

detection of light stimulus involved in sensory perception [inference]

detection of light stimulus involved in visual perception

detection of abiotic stimulus [inference]

detection of light stimulus [inference]

detection of visible light [inference]

detection of light stimulus involved in visual perception

detection of light stimulus involved in sensory perception [inference]

detection of light stimulus involved in visual perception

detection of stimulus involved in sensory perception [inference]

detection of light stimulus involved in sensory perception [inference]

detection of light stimulus involved in visual perception

cellular response to stimulus [inference]

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to light stimulus

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
photoreceptor outer segment	IEA
photoreceptor inner segment	IEA
extracellular region	IEA
plasma membrane	IBA
microvillus	IEA

GO Hierarchy

cellular component

protein-containing complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

subapical complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

apical plasma membrane

cell junction [inference]

anchoring junction [inference]

cell-cell junction [inference]

cell projection [inference]

plasma membrane bounded cell projection [inference]

glial cell projection

actin-based cell projection [inference]

microvillus

Displaying **all 2** entries
GO Term	Evidence Code	PMID
calcium ion binding	IEA
protein binding	IPI	11927608 15914641 17920587 33758649

GO Hierarchy

molecular function

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

crumbs

Functional Category

G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
calcium ion binding

Displaying **all 8** entries
InterPro
Concanavalin A-like lectin/glucanase domain superfamily
EGF-like calcium-binding domain
EGF-like calcium-binding, conserved site
EGF-like domain
EGF-like, conserved site
EGF-type aspartate/asparagine hydroxylation site
Growth factor receptor cysteine-rich domain superfamily
Laminin G domain

Disease

Disease Ontology

Displaying **all 6** entries
DO ID	Disease Name	Source
DOID:0050572	cone-rod dystrophy	Alliance of Genome Resources
DOID:0110079	Leber congenital amaurosis 8	Alliance of Genome Resources
DOID:0110358	retinitis pigmentosa 12	Alliance of Genome Resources
DOID:0111541	pigmented paravenous chorioretinal atrophy	Alliance of Genome Resources
DOID:10584	retinitis pigmentosa	Alliance of Genome Resources
DOID:14791	Leber congenital amaurosis	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 56 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	23418	Xenbase:XB-GENE-483760
Danio rerio	42896	ZFIN:ZDB-GENE-050208-382
Mus musculus	170788	Xenbase:XB-GENE-483760	MOUSE30411
Drosophila melanogaster	241324	FB:FBgn0259685
Caenorhabditis elegans	286204	WB:WBGene00000792
Rattus norvegicus	304825		RATNO06635
Pan troglodytes	469626		PANTR23283
Canis lupus familiaris	490260		CANLF17071
Bos taurus	520406		BOVIN08913
Danio rerio	560942		DANRE23036

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements