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MIRAGE

G protein-coupled receptor 161

Summary

Gene Symbol

GPR161

Organism

Homo sapiens (human)

External Links

NCBI Gene

23432

PubChem

23432

Alliance of Genome Resources

HGNC:23694

JoGo

GPR161

TogoVar

GPR161

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Cilium
Developmental protein
Disulfide bond
G-protein coupled receptor
Glycoprotein
Proteomics identification
Reference proteome
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A0A0MQW8
Q8N6U8	G-protein coupled receptor RE2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
G protein-coupled receptor signaling pathway	IBA
adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISS
negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning	ISS

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of smoothened signaling pathway [inference]

negative regulation of smoothened signaling pathway [inference]

negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning

regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning [inference]

negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning

negative regulation of signal transduction [inference]

negative regulation of smoothened signaling pathway [inference]

negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of smoothened signaling pathway [inference]

negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of smoothened signaling pathway [inference]

negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of smoothened signaling pathway [inference]

negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of smoothened signaling pathway [inference]

negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of smoothened signaling pathway [inference]

negative regulation of smoothened signaling pathway [inference]

negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning

regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning [inference]

negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning

negative regulation of signal transduction [inference]

negative regulation of smoothened signaling pathway [inference]

negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of smoothened signaling pathway [inference]

negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of smoothened signaling pathway [inference]

negative regulation of smoothened signaling pathway [inference]

negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning

regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning [inference]

negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning

negative regulation of signal transduction [inference]

negative regulation of smoothened signaling pathway [inference]

negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of smoothened signaling pathway [inference]

negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of smoothened signaling pathway [inference]

negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning

Displaying entries **1 - 5** of 8 in total

1

2

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GO Term	Evidence Code	PMID
plasma membrane
cilium	ISS
endocytic vesicle membrane	TAS
neuron projection	IEA
recycling endosome	ISS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endocytic vesicle membrane

bounding membrane of organelle [inference]

plasma membrane region [inference]

cell projection membrane [inference]

ciliary membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

organelle [inference]

membrane-bounded organelle [inference]

cilium

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

recycling endosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

recycling endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

recycling endosome

Displaying **all 3** entries
GO Term	Evidence Code	PMID
G protein-coupled receptor activity	ISS
G protein-coupled receptor activity	IBA
protein binding	IPI	32296183

GO Hierarchy

molecular function

binding [inference]

protein binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

G-protein coupled receptor

Functional Category

E: Amino acid transport and metabolism
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
InterPro
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0050902	medulloblastoma	Alliance of Genome Resources

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Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025