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ATP binding cassette subfamily A member 5

Summary

Gene Symbol

ABCA5

Organism

Homo sapiens (human)

External Links

NCBI Gene

23461

PubChem

23461

Alliance of Genome Resources

HGNC:35

Annotation

Keyword

ATP-binding
Alternative splicing
Cell membrane
Endosome
Glycoprotein
Golgi apparatus
Lipid transport
Lysosome
Reference proteome
Repeat
Translocase
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8WWZ7	ATP-binding cassette sub-family A member 5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
cholesterol metabolic process	IMP	25125465
positive regulation of reverse cholesterol transport	ISS
reverse cholesterol transport	IC	20382126
cholesterol efflux	ISS	20382126
transmembrane transport	IEA

GO Hierarchy

biological process

metabolic process [inference]

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

sterol metabolic process [inference]

cholesterol metabolic process

cellular process [inference]

transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

protein-containing complex organization [inference]

protein-containing complex remodeling [inference]

protein-lipid complex remodeling [inference]

plasma lipoprotein particle remodeling [inference]

high-density lipoprotein particle remodeling

protein-lipid complex organization [inference]

protein-lipid complex remodeling [inference]

plasma lipoprotein particle remodeling [inference]

high-density lipoprotein particle remodeling

plasma lipoprotein particle organization [inference]

plasma lipoprotein particle remodeling [inference]

high-density lipoprotein particle remodeling

multicellular organismal process [inference]

plasma lipoprotein particle organization [inference]

plasma lipoprotein particle remodeling [inference]

high-density lipoprotein particle remodeling

homeostatic process [inference]

chemical homeostasis [inference]

lipid homeostasis [inference]

sterol homeostasis [inference]

cholesterol homeostasis

localization [inference]

establishment of localization [inference]

transport [inference]

transmembrane transport

organic substance transport [inference]

lipid transport

sterol transport [inference]

cholesterol transport [inference]

organic hydroxy compound transport [inference]

sterol transport [inference]

cholesterol transport [inference]

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of lipid transport [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of reverse cholesterol transport

regulation of sterol transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of reverse cholesterol transport

regulation of cholesterol transport [inference]

regulation of cholesterol efflux

positive regulation of cholesterol transport [inference]

positive regulation of reverse cholesterol transport

regulation of reverse cholesterol transport [inference]

positive regulation of reverse cholesterol transport

positive regulation of transport [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of reverse cholesterol transport

regulation of lipid localization [inference]

regulation of lipid transport [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of reverse cholesterol transport

regulation of sterol transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of reverse cholesterol transport

regulation of cholesterol transport [inference]

regulation of cholesterol efflux

positive regulation of cholesterol transport [inference]

positive regulation of reverse cholesterol transport

regulation of reverse cholesterol transport [inference]

positive regulation of reverse cholesterol transport

positive regulation of lipid localization [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of reverse cholesterol transport

positive regulation of biological process [inference]

positive regulation of transport [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of reverse cholesterol transport

positive regulation of lipid localization [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of reverse cholesterol transport

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell differentiation [inference]

negative regulation of macrophage derived foam cell differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of macrophage derived foam cell differentiation

regulation of developmental process [inference]

regulation of cell differentiation [inference]

regulation of macrophage derived foam cell differentiation [inference]

negative regulation of macrophage derived foam cell differentiation

negative regulation of cell differentiation [inference]

negative regulation of macrophage derived foam cell differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of macrophage derived foam cell differentiation

regulation of cellular process [inference]

regulation of cell differentiation [inference]

regulation of macrophage derived foam cell differentiation [inference]

negative regulation of macrophage derived foam cell differentiation

negative regulation of cell differentiation [inference]

negative regulation of macrophage derived foam cell differentiation

negative regulation of cellular process [inference]

negative regulation of cell differentiation [inference]

negative regulation of macrophage derived foam cell differentiation

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
late endosome	IBA ISS	15870284
plasma membrane	IEA
late endosome membrane	IEA
lysosome	ISS	15870284
Golgi membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane [inference]

late endosome membrane

bounding membrane of organelle [inference]

Golgi membrane

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

endosome membrane [inference]

late endosome membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome

Displaying **all 5** entries
GO Term	Evidence Code	PMID
ABC-type transporter activity	IEA
ATP hydrolysis activity	IEA
lipid transporter activity	IBA TAS
ATPase-coupled transmembrane transporter activity	IBA
ATP binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

transporter activity [inference]

lipid transporter activity

transmembrane transporter activity [inference]

active transmembrane transporter activity [inference]

primary active transmembrane transporter activity [inference]

ATPase-coupled transmembrane transporter activity

ABC-type transporter activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

ATPase-coupled transmembrane transporter activity

ABC-type transporter activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ATP-binding cassette, sub-family A

Functional Category

K: Transcription
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
ABC-type transporter activity
ATP binding
lipid transporter activity
nucleotide binding

Displaying **all 6** entries
InterPro
AAA+ ATPase domain
ABC transporter A
ABC transporter-like, ATP-binding domain
ABC transporter-like, conserved site
ABC-2 type transporter, transmembrane domain
P-loop containing nucleoside triphosphate hydrolase

Ortholog

Displaying entries **1 - 10** of 94 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	182849		WB:WBGene00000019
Mus musculus	217265		MGI:2386607	MOUSE06697
Rattus norvegicus	286970		RGD:628661	RATNO01205
Pan troglodytes	454848	9598_0:0043af		PANTR15295
Canis lupus familiaris	480455			CANLF18599
Bos taurus	510497			BOVIN14090
Macaca mulatta	693795			MACMU15277
Monodelphis domestica	100024311			MONDO10943
Equus caballus	100053093			HORSE04274
Ornithorhynchus anatinus	100078425			ORNAN07162