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alanyl-tRNA synthetase 1

Summary

Gene Symbol

Aars1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

234734

PubChem

234734

Alliance of Genome Resources

MGI:2384560

Annotation

Keyword

ATP-binding
Acetylation
Aminoacyl-tRNA synthetase
Cytoplasm
Disease variant
Metal-binding
Methylation
Phosphoprotein
Protein biosynthesis
Reference proteome
Ubl conjugation
Zinc
tRNA-binding

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q8BGQ7	Alanyl-tRNA synthetase Protein sticky
Q3UD67

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
tRNA modification	IDA	25422440
tRNA modification	IMP	16906134 29769718
alanyl-tRNA aminoacylation	ISO
alanyl-tRNA aminoacylation	IDA	27622773
alanyl-tRNA aminoacylation	IMP	16906134

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification

RNA modification [inference]

tRNA modification

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

alanyl-tRNA aminoacylation

aminoacyl-tRNA metabolism involved in translational fidelity

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

amino acid activation [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

alanyl-tRNA aminoacylation

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid activation [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

alanyl-tRNA aminoacylation

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification

RNA modification [inference]

tRNA modification

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

alanyl-tRNA aminoacylation

aminoacyl-tRNA metabolism involved in translational fidelity

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification

RNA modification [inference]

tRNA modification

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

alanyl-tRNA aminoacylation

aminoacyl-tRNA metabolism involved in translational fidelity

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification

RNA modification [inference]

tRNA modification

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

alanyl-tRNA aminoacylation

aminoacyl-tRNA metabolism involved in translational fidelity

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification

RNA modification [inference]

tRNA modification

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

alanyl-tRNA aminoacylation

aminoacyl-tRNA metabolism involved in translational fidelity

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification

amino acid metabolic process [inference]

amino acid activation [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

alanyl-tRNA aminoacylation

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid activation [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

alanyl-tRNA aminoacylation

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid activation [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

alanyl-tRNA aminoacylation

macromolecule metabolic process [inference]

macromolecule modification [inference]

RNA modification [inference]

tRNA modification

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification

RNA modification [inference]

tRNA modification

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

alanyl-tRNA aminoacylation

aminoacyl-tRNA metabolism involved in translational fidelity

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification

RNA modification [inference]

tRNA modification

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

alanyl-tRNA aminoacylation

aminoacyl-tRNA metabolism involved in translational fidelity

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

amino acid activation [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

alanyl-tRNA aminoacylation

cellular process [inference]

cell death [inference]

programmed cell death [inference]

apoptotic process [inference]

neuron apoptotic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid activation [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

alanyl-tRNA aminoacylation

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification

RNA modification [inference]

tRNA modification

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

alanyl-tRNA aminoacylation

aminoacyl-tRNA metabolism involved in translational fidelity

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification

RNA modification [inference]

tRNA modification

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

alanyl-tRNA aminoacylation

aminoacyl-tRNA metabolism involved in translational fidelity

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification

RNA modification [inference]

tRNA modification

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

alanyl-tRNA aminoacylation

aminoacyl-tRNA metabolism involved in translational fidelity

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

neuromuscular process

neuromuscular process controlling balance

developmental process [inference]

anatomical structure development [inference]

cerebellar Purkinje cell layer development

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

regulation of translational elongation [inference]

regulation of cytoplasmic translational elongation [inference]

regulation of cytoplasmic translational fidelity

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

regulation of translational elongation [inference]

regulation of cytoplasmic translational elongation [inference]

regulation of cytoplasmic translational fidelity

regulation of nitrogen compound metabolic process [inference]

regulation of amide metabolic process [inference]

regulation of translation [inference]

regulation of translational elongation [inference]

regulation of cytoplasmic translational elongation [inference]

regulation of cytoplasmic translational fidelity

regulation of protein metabolic process [inference]

regulation of translation [inference]

regulation of translational elongation [inference]

regulation of cytoplasmic translational elongation [inference]

regulation of cytoplasmic translational fidelity

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

regulation of translational elongation [inference]

regulation of cytoplasmic translational elongation [inference]

regulation of cytoplasmic translational fidelity

regulation of protein metabolic process [inference]

regulation of translation [inference]

regulation of translational elongation [inference]

regulation of cytoplasmic translational elongation [inference]

regulation of cytoplasmic translational fidelity

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of translation [inference]

regulation of translational elongation [inference]

regulation of cytoplasmic translational elongation [inference]

regulation of cytoplasmic translational fidelity

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of hippo signaling

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of signal transduction by p53 class mediator

regulation of intracellular signal transduction [inference]

regulation of hippo signaling [inference]

positive regulation of hippo signaling

regulation of signal transduction by p53 class mediator [inference]

negative regulation of signal transduction by p53 class mediator

negative regulation of intracellular signal transduction [inference]

negative regulation of signal transduction by p53 class mediator

positive regulation of intracellular signal transduction [inference]

positive regulation of hippo signaling

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of hippo signaling

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of signal transduction by p53 class mediator

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of hippo signaling

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of hippo signaling

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of hippo signaling

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of signal transduction by p53 class mediator

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of signal transduction by p53 class mediator

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of signal transduction by p53 class mediator

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of hippo signaling

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of signal transduction by p53 class mediator

regulation of intracellular signal transduction [inference]

regulation of hippo signaling [inference]

positive regulation of hippo signaling

regulation of signal transduction by p53 class mediator [inference]

negative regulation of signal transduction by p53 class mediator

negative regulation of intracellular signal transduction [inference]

negative regulation of signal transduction by p53 class mediator

positive regulation of intracellular signal transduction [inference]

positive regulation of hippo signaling

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of hippo signaling

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of signal transduction by p53 class mediator

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of hippo signaling

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of signal transduction by p53 class mediator

regulation of intracellular signal transduction [inference]

regulation of hippo signaling [inference]

positive regulation of hippo signaling

regulation of signal transduction by p53 class mediator [inference]

negative regulation of signal transduction by p53 class mediator

negative regulation of intracellular signal transduction [inference]

negative regulation of signal transduction by p53 class mediator

positive regulation of intracellular signal transduction [inference]

positive regulation of hippo signaling

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of hippo signaling

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of signal transduction by p53 class mediator

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

regulation of translational elongation [inference]

regulation of cytoplasmic translational elongation [inference]

regulation of cytoplasmic translational fidelity

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

regulation of neuron apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of hippo signaling

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of signal transduction by p53 class mediator

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

regulation of biological quality [inference]

regulation of translational fidelity [inference]

Displaying **all 5** entries
GO Term	Evidence Code	PMID
nucleus	ISS
cytoplasm	ISS
mitochondrion	IBA
cytosol	ISO
cytosol	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
tRNA binding	ISO
tRNA binding	IEA
aminoacyl-tRNA editing activity	ISO
aminoacyl-tRNA editing activity	IDA	20010690
aminoacyl-tRNA editing activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

carboxylic ester hydrolase activity [inference]

aminoacyl-tRNA editing activity

Ser-tRNA(Ala) hydrolase activity

ligase activity [inference]

ligase activity, forming carbon-oxygen bonds [inference]

aminoacyl-tRNA ligase activity [inference]

alanine-tRNA ligase activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on RNA [inference]

catalytic activity, acting on a tRNA [inference]

aminoacyl-tRNA editing activity

Ser-tRNA(Ala) hydrolase activity

aminoacyl-tRNA ligase activity [inference]

alanine-tRNA ligase activity

binding [inference]

protein binding

small molecule binding [inference]

organic acid binding [inference]

carboxylic acid binding [inference]

amino acid binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

carboxylic acid binding [inference]

amino acid binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding [inference]

tRNA binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

alanine--tRNA ligase

Functional Category

J: Translation, ribosomal structure and biogenesis
K: Transcription
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying **all 9** entries
Gene Ontology
ATP binding
alanine-tRNA ligase activity
alanyl-tRNA aminoacylation
aminoacyl-tRNA editing activity
ligase activity
metal ion binding
nucleotide binding
tRNA aminoacylation
zinc ion binding

Displaying **all 10** entries
InterPro
Alanine-tRNA ligase, class IIc, anti-codon-binding domain superfamily
Alanine-tRNA ligase, class IIc
Alanine-tRNA ligase, eukaryota/bacteria
Alanyl-tRNA synthetase, class IIc, N-terminal
Alanyl-tRNA synthetase, class IIc, core domain
Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL)
DHHA1 domain
Threonyl/alanyl tRNA synthetase, SAD
Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain superfamily
Translation protein, beta-barrel domain superfamily

Ortholog

Displaying entries **1 - 10** of **113** in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	16	Xenbase:XB-GENE-963523	HUMAN29430
Saccharomyces cerevisiae S288C	57505	SGD:S000005862
Xenopus tropicalis	234734	Xenbase:XB-GENE-963523
Rattus norvegicus	292023		RATNO14584
Danio rerio	324940		DANRE14337
Pan troglodytes	454210		PANTR12746
Canis lupus familiaris	479656		CANLF15958
Bos taurus	510933		BOVIN10123
Macaca mulatta	709492		MACMU27494
Monodelphis domestica	100011180		MONDO07783

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Acknowledgements