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bromodomain containing 4
Summary
- Gene Symbol
-
- BRD4
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Acetylation
- Alternative splicing
- Bromodomain
- Chromatin regulator
- Chromosomal rearrangement
- Chromosome
- DNA damage
- Disease variant
- Host-virus interaction
- Intellectual disability
- Isopeptide bond
- Nucleus
- Phosphoprotein
- Reference proteome
- Repeat
- Transcription regulation
- Ubl conjugation
- Proteins
| UniProt | Protein Name |
|---|---|
| O60885 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| chromatin remodeling | ||
| chromatin remodeling | ||
| regulation of transcription by RNA polymerase II | ||
| regulation of transcription by RNA polymerase II | ||
| DNA damage response |
GO Hierarchy
biological process
biological regulation [inference]
regulation of biological process [inference]
regulation of immune system process [inference]
positive regulation of immune system process [inference]
regulation of leukocyte activation [inference]
positive regulation of leukocyte activation [inference]
regulation of lymphocyte activation [inference]
regulation of lymphocyte differentiation [inference]
regulation of T cell activation [inference]
regulation of T cell differentiation [inference]
regulation of alpha-beta T cell activation [inference]
regulation of immune effector process [inference]
regulation of immune response [inference]
regulation of hemopoiesis [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
positive regulation of biosynthetic process [inference]
regulation of cellular biosynthetic process [inference]
positive regulation of metabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
positive regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of macromolecule biosynthetic process [inference]
positive regulation of macromolecule metabolic process [inference]
regulation of RNA metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
regulation of signaling [inference]
positive regulation of biological process [inference]
positive regulation of immune system process [inference]
positive regulation of metabolic process [inference]
positive regulation of cellular process [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of cell differentiation [inference]
positive regulation of cell adhesion [inference]
positive regulation of cell cycle [inference]
positive regulation of cell activation [inference]
positive regulation of response to stimulus [inference]
positive regulation of developmental process [inference]
positive regulation of multicellular organismal process [inference]
regulation of response to stimulus [inference]
regulation of signal transduction [inference]
positive regulation of response to stimulus [inference]
regulation of immune response [inference]
regulation of developmental process [inference]
regulation of cell differentiation [inference]
positive regulation of cell differentiation [inference]
regulation of cell development [inference]
regulation of hemopoiesis [inference]
positive regulation of developmental process [inference]
regulation of multicellular organismal development [inference]
regulation of hemopoiesis [inference]
regulation of cellular process [inference]
regulation of cell communication [inference]
regulation of cell adhesion [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
positive regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of cell differentiation [inference]
positive regulation of cell differentiation [inference]
regulation of cell development [inference]
regulation of hemopoiesis [inference]
positive regulation of cellular process [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of cell differentiation [inference]
positive regulation of cell adhesion [inference]
positive regulation of cell cycle [inference]
positive regulation of cell activation [inference]
regulation of cell activation [inference]
regulation of leukocyte activation [inference]
positive regulation of leukocyte activation [inference]
regulation of lymphocyte activation [inference]
regulation of lymphocyte differentiation [inference]
regulation of T cell activation [inference]
regulation of T cell differentiation [inference]
regulation of alpha-beta T cell activation [inference]
positive regulation of cell activation [inference]
regulation of cell cycle [inference]
regulation of multicellular organismal process [inference]
regulation of cell activation [inference]
regulation of leukocyte activation [inference]
positive regulation of leukocyte activation [inference]
regulation of lymphocyte activation [inference]
regulation of lymphocyte differentiation [inference]
regulation of T cell activation [inference]
regulation of T cell differentiation [inference]
regulation of alpha-beta T cell activation [inference]
positive regulation of cell activation [inference]
positive regulation of multicellular organismal process [inference]
regulation of multicellular organismal development [inference]
regulation of hemopoiesis [inference]
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| transcription cis-regulatory region binding | ||
| p53 binding | ||
| chromatin binding | ||
| chromatin binding | ||
| transcription coregulator activity |
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- bromodomain
- Functional Category
-
- C: Energy production and conversion
- K: Transcription
- T: Signal transduction mechanisms
| InterPro |
|---|
| Bromodomain-like superfamily |
| Bromodomain |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050156 | idiopathic pulmonary fibrosis | |
| DOID:0060970 | Cornelia de Lange syndrome 6 | |
| DOID:219 | colon cancer |
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 6046 | SGD:S000004391 | ||
| 8019 | SGD:S000004391 | ||
| 23476 | Xenbase:XB-GENE-5859147 | ||
| 31722 | SGD:S000004391 | ||
| 57261 | MOUSE22850 | ||
| 67382 | SGD:S000004391 | ||
| 362844 | RATNO39597 | ||
| 455794 | PANTR17457 | ||
| 484869 | CANLF07726 | ||
| 718195 | MACMU20548 |
