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MIRAGE
TDP-glucose 4,6-dehydratase

Summary
Gene Symbol
  • TGDS
Aliases
  • SDR2E1
  • TDPGD
  • short chain dehydrogenase/reductase family 2E, member 1
Organism
Homo sapiens (human)
NCBI Gene
23483
HGNC
20324
KEGG Gene ID
hsa:23483
PubChem
23483
Alliance of Genome Resources
JoGo
TGDS
TogoVar
TGDS
Annotation
Keyword
  • Disease variant
  • Endoplasmic reticulum
  • Golgi apparatus
  • Lyase
  • NAD
  • Proteomics identification
  • Reference proteome
Proteins
Displaying 1 entry
UniProt Protein Name
O95455
  • dTDP-D-glucose 4,6-dehydratase
Annotation information from UniProt.
Gene Ontology (GO)
Displaying 1 entry
GO Term Evidence Code PMID
nucleotide-sugar metabolic process
GO Hierarchy
Gene Ontology information from NCBI Gene and UniProt.
OrthoDB (Group)
Group level
Eukaryota
Group Name
sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating)
Functional Category
  • I: Lipid transport and metabolism
  • M: Cell wall/membrane/envelope biogenesis
  • P: Inorganic ion transport and metabolism
Displaying all 3 entries
Gene Ontology
3-beta-hydroxy-delta5-steroid dehydrogenase activity
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
steroid biosynthetic process
Displaying all 2 entries
InterPro
3-beta hydroxysteroid dehydrogenase/isomerase
NAD(P)-binding domain superfamily
KEGG BRITE Database
Orthology
K01710
Name
dTDP-glucose 4,6-dehydratase [EC:4.2.1.46]
References
Rhea

RHEA:17221

dTDP-α-D-glucose
H2O + dTDP-4-dehydro-6-deoxy-α-D-glucose
Enzyme
PMID
Disease
Disease Ontology
Displaying 1 entry
DO ID Disease Name Source
DOID:0081122 Catel Manzke syndrome
The Human Phenotype Ontology
Displaying entries 1 - 10 of 63 in total
HPO ID HPO Term
HP:0000007 Autosomal recessive inheritance
HP:0000023 Inguinal hernia
HP:0000028 Cryptorchidism
HP:0000160 Narrow mouth
HP:0000162 Glossoptosis
HP:0000175 Cleft palate
HP:0000193 Bifid uvula
HP:0000201 Pierre-Robin sequence
HP:0000204 Cleft upper lip
HP:0000218 High palate
Displaying all 2 entries
Disease ID Disease Name
ORPHA:1388
  • Catel-Manzke syndrome
OMIM:616145
  • Catel-Manzke syndrome
PubChem Disease
MedGen Diseases
OMIM Phenotypes
KEGG Diseases
Gene-Disease-Co-Occurrences-in-Literature (PubChem)
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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026