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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
folate receptor alpha
Summary
- Gene Symbol
-
- FOLR1
- Aliases
-
- FRĪ±
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Cell membrane
- Cytoplasmic vesicle
- Direct protein sequencing
- Disulfide bond
- Endosome
- Folate-binding
- GPI-anchor
- Neurodegeneration
- Receptor
- Reference proteome
- Secreted
- Signal
- Transport
- Proteins
| UniProt | Protein Name |
|---|---|
| P15328 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| anterior neural tube closure | ||
| sperm-egg recognition | ||
| fusion of sperm to egg plasma membrane involved in single fertilization | ||
| axon regeneration | ||
| regulation of canonical Wnt signaling pathway |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| extracellular exosome |
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein binding | ||
| signaling receptor activity | ||
| folic acid receptor activity | ||
| folic acid binding |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- Folate receptor
- Functional Category
-
- O: Posttranslational modification, protein turnover, chaperones
- Q: Secondary metabolites biosynthesis, transport and catabolism
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| fusion of sperm to egg plasma membrane involved in single fertilization |
| sperm-egg recognition |
| InterPro |
|---|
| Folate receptor-like |
| Folate receptor |
Disease
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0000007 | Autosomal recessive inheritance |
| HP:0001249 | Intellectual disability |
| HP:0001250 | Seizure |
| HP:0002180 | Neurodegeneration |
| HP:0002376 | Developmental regression |
| Disease ID | Disease Name |
|---|---|
| OMIM:613068 |
|
PubChem Disease
- GHR Health Conditions
- MedGen Diseases
- OMIM Phenotypes
- KEGG Diseases
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 14275 | MGI:95568 | MOUSE56360 | ||
| 171049 | RGD:71032 | RATNO19865 | ||
| 394697 | Xenbase:XB-GENE-948101 | |||
| 396784 | PIGXX34930 | |||
| 397579 | PIGXX34930 | |||
| 444543 | Xenbase:XB-GENE-6254887 | |||
| 451401 | 9598_0:003335 | PANTR03738 | ||
| 539750 | BOVIN07162 | |||
| 609612 | CANLF08307 | |||
| 718388 | MACMU10177 |
