GlyCosmos Portal

Submissions

hyaluronidase 4

Summary

Gene Symbol

HYAL4

Organism

Homo sapiens (human)

External Links

NCBI Gene

23553

HGNC

5323

KEGG Gene ID

hsa:23553

PubChem

23553

Alliance of Genome Resources

HGNC:5323

Annotation

Keyword

Disulfide bond
EGF-like domain
Glycoprotein
Glycosidase
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q2M3T9	Chondroitin sulfate endo-beta-N-acetylgalactosaminidase Chondroitin sulfate hydrolase Hyaluronoglucosaminidase-4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
hyaluronan catabolic process	IBA
chondroitin sulfate catabolic process	IEA
glycosaminoglycan catabolic process	TAS	10493834
carbohydrate metabolic process	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan catabolic process

mucopolysaccharide metabolic process [inference]

chondroitin sulfate metabolic process [inference]

chondroitin sulfate catabolic process

hyaluronan metabolic process [inference]

hyaluronan catabolic process

organonitrogen compound catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process

catabolic process [inference]

cellular catabolic process [inference]

sulfur compound catabolic process [inference]

chondroitin sulfate catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process

carbohydrate derivative catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process

organonitrogen compound catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process

cellular metabolic process [inference]

sulfur compound metabolic process [inference]

chondroitin sulfate metabolic process [inference]

chondroitin sulfate catabolic process

sulfur compound catabolic process [inference]

chondroitin sulfate catabolic process

cellular catabolic process [inference]

sulfur compound catabolic process [inference]

chondroitin sulfate catabolic process

primary metabolic process [inference]

carbohydrate metabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process

macromolecule metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan catabolic process

mucopolysaccharide metabolic process [inference]

chondroitin sulfate metabolic process [inference]

chondroitin sulfate catabolic process

hyaluronan metabolic process [inference]

hyaluronan catabolic process

macromolecule catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process

carbohydrate derivative metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan catabolic process

mucopolysaccharide metabolic process [inference]

chondroitin sulfate metabolic process [inference]

chondroitin sulfate catabolic process

hyaluronan metabolic process [inference]

hyaluronan catabolic process

carbohydrate derivative catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process

organonitrogen compound metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan catabolic process

mucopolysaccharide metabolic process [inference]

chondroitin sulfate metabolic process [inference]

chondroitin sulfate catabolic process

hyaluronan metabolic process [inference]

hyaluronan catabolic process

organonitrogen compound catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process

carbohydrate derivative catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process

organonitrogen compound catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process

cellular process [inference]

cellular metabolic process [inference]

sulfur compound metabolic process [inference]

chondroitin sulfate metabolic process [inference]

chondroitin sulfate catabolic process

sulfur compound catabolic process [inference]

chondroitin sulfate catabolic process

cellular catabolic process [inference]

sulfur compound catabolic process [inference]

chondroitin sulfate catabolic process

Displaying **all 3** entries
GO Term	Evidence Code	PMID
cytoplasmic vesicle	IBA
membrane	IEA
cell surface	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

Displaying **all 2** entries
GO Term	Evidence Code	PMID
protein binding	IPI	28514442 33961781
hyalurononglucosaminidase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing O-glycosyl compounds [inference]

hexosaminidase activity [inference]

hyalurononglucosaminidase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Hyaluronidase

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
hyaluronan catabolic process
hyalurononglucosaminidase activity
hydrolase activity, acting on glycosyl bonds
hydrolase activity

Displaying **all 3** entries
InterPro
Aldolase-type TIM barrel
Glycoside hydrolase superfamily
Hyaluronidase

KEGG BRITE Database

Orthology

K01197

Name

hyaluronoglucosaminidase [EC:3.2.1.35]

References

Reactions

Displaying **all 3** entries
KEGG Reaction	Enzyme	Acceptor	Product
R10905	3.2.1.35	G16235VG	G16235VG G93263XO
R07824	3.2.1.35	G81393WR	G92988PL
R07825	3.2.1.35	G34586BV	G92988PL

Ortholog

Displaying entries **1 - 10** of 94 in total

1

2

3

4

5

…

Next ›

Last »
Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	77042		MGI:1924292	MOUSE49660
Caenorhabditis elegans	174383		WB:WBGene00011923
Rattus norvegicus	404783		RGD:1303194	RATNO29435
Pan troglodytes	472497	9598_0:00209c		PANTR41301
Canis lupus familiaris	475212			CANLF03609
Bos taurus	518161			BOVIN28355
Macaca mulatta	696128			MACMU33164
Monodelphis domestica	100017029			MONDO33545
Xenopus tropicalis	100037890		Xenbase:XB-GENE-995975
Equus caballus	100056514			HORSE32059