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phosphatidylinositol glycan anchor biosynthesis class N

Summary

Gene Symbol

PIGN

Aliases

GPI ethanolamine phosphate transferase 1
MCD4
PIG-N

Organism

Homo sapiens (human)

External Links

NCBI Gene

23556

GGDB ID

gg224

HGNC

8967

mRNA

NM_176787

map

18q21.33

Protein

NP_789744

OMIM

606097

KEGG Gene ID

hsa:23556

PubChem

23556

Alliance of Genome Resources

HGNC:8967

Annotation

Keyword

Disease variant
Endoplasmic reticulum
Epilepsy
GPI-anchor biosynthesis
Glycoprotein
Proteomics identification
Reference proteome
Transferase
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
O95427	MCD4 homolog Phosphatidylinositol-glycan biosynthesis class N protein
A0A1W2PQA9

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
GPI anchor biosynthetic process	IBA TAS
preassembly of GPI anchor in ER membrane

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein lipidation [inference]

GPI anchor biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

preassembly of GPI anchor in ER membrane

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

preassembly of GPI anchor in ER membrane

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

preassembly of GPI anchor in ER membrane

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

preassembly of GPI anchor in ER membrane

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

preassembly of GPI anchor in ER membrane

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

preassembly of GPI anchor in ER membrane

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

protein metabolic process [inference]

protein modification process [inference]

protein lipidation [inference]

GPI anchor biosynthetic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

preassembly of GPI anchor in ER membrane

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

preassembly of GPI anchor in ER membrane

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

preassembly of GPI anchor in ER membrane

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein lipidation [inference]

GPI anchor biosynthetic process

macromolecule modification [inference]

protein modification process [inference]

protein lipidation [inference]

GPI anchor biosynthetic process

carbohydrate derivative metabolic process [inference]

carbohydrate derivative biosynthetic process [inference]

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein lipidation [inference]

GPI anchor biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

preassembly of GPI anchor in ER membrane

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

preassembly of GPI anchor in ER membrane

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

preassembly of GPI anchor in ER membrane

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

preassembly of GPI anchor in ER membrane

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

Displaying **all 4** entries
GO Term	Evidence Code	PMID
membrane	HDA	19946888
endoplasmic reticulum membrane	IBA TAS
plasma membrane	IDA
cytosol	IDA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

Displaying 1 entry
GO Term	Evidence Code	PMID
mannose-ethanolamine phosphotransferase activity	IBA TAS

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

phosphotransferase activity, for other substituted phosphate groups [inference]

mannose-ethanolamine phosphotransferase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

GPI ethanolamine phosphate transferase

Functional Category

G: Carbohydrate transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
mannose-ethanolamine phosphotransferase activity
transferase activity

Displaying **all 5** entries
InterPro
Alkaline-phosphatase-like, core domain superfamily
GPI ethanolamine phosphate transferase 1, C-terminal
GPI ethanolamine phosphate transferase 1, N-terminal
GPI ethanolamine phosphate transferase 1
Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase

Human Protein Atlas

ENSG00000197563