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SREBF chaperone

Summary

Gene Symbol

Scap

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

235623

PubChem

235623

Alliance of Genome Resources

MGI:2135958

Annotation

Keyword

Cholesterol metabolism
Cytoplasmic vesicle
Endoplasmic reticulum
Glycoprotein
Golgi apparatus
Isopeptide bond
Lipid-binding
Methylation
Phosphoprotein
Reference proteome
Repeat
Transmembrane helix
Ubl conjugation
WD repeat

Proteins

Displaying 1 entry
UniProt	Protein Name
Q6GQT6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
response to hypoxia	IMP	17666524
lipid metabolic process	IMP	22337502
immune response	IMP	22337502
cholesterol metabolic process	IDA	11358865
regulation of fatty acid metabolic process	IDA	11358865

GO Hierarchy

biological process

immune system process [inference]

immune response

metabolic process [inference]

cellular metabolic process [inference]

cellular lipid metabolic process

primary metabolic process [inference]

lipid metabolic process

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

cellular lipid metabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

organic substance metabolic process [inference]

lipid metabolic process

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

cellular lipid metabolic process

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

sterol metabolic process [inference]

cholesterol metabolic process

cellular process [inference]

signal transduction [inference]

ER-nucleus signaling pathway [inference]

SREBP signaling pathway

cellular metabolic process [inference]

cellular lipid metabolic process

cellular localization [inference]

intracellular transport [inference]

COPII-coated vesicle cargo loading

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to sterol depletion [inference]

SREBP signaling pathway

response to stimulus [inference]

response to stress [inference]

response to hypoxia

response to sterol depletion [inference]

cellular response to sterol depletion [inference]

SREBP signaling pathway

cellular response to stress [inference]

cellular response to sterol depletion [inference]

SREBP signaling pathway

immune response

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to nutrient [inference]

response to vitamin [inference]

response to vitamin B3

response to abiotic stimulus [inference]

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia

response to endogenous stimulus [inference]

response to hormone [inference]

response to peptide hormone [inference]

response to insulin

response to chemical [inference]

response to nutrient [inference]

response to vitamin [inference]

response to vitamin B3

response to organic substance [inference]

response to hormone [inference]

response to peptide hormone [inference]

response to insulin

response to organonitrogen compound [inference]

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

response to oxygen-containing compound [inference]

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to sterol depletion [inference]

SREBP signaling pathway

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle cargo loading [inference]

COPII-coated vesicle cargo loading

intracellular transport [inference]

COPII-coated vesicle cargo loading

establishment of localization in cell [inference]

intracellular transport [inference]

COPII-coated vesicle cargo loading

cellular localization [inference]

intracellular transport [inference]

COPII-coated vesicle cargo loading

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of sterol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of alcohol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of fatty acid biosynthetic process

regulation of lipid biosynthetic process [inference]

regulation of fatty acid biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of sterol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

regulation of steroid biosynthetic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of sterol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

regulation of sterol biosynthetic process [inference]

regulation of cholesterol biosynthetic process

positive regulation of cholesterol biosynthetic process

positive regulation of sterol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

regulation of alcohol biosynthetic process [inference]

regulation of cholesterol biosynthetic process

positive regulation of cholesterol biosynthetic process

positive regulation of alcohol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of sterol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of alcohol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of lipid metabolic process [inference]

positive regulation of steroid metabolic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of sterol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of cholesterol metabolic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of sterol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of small molecule metabolic process [inference]

positive regulation of cholesterol metabolic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of alcohol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

regulation of cellular metabolic process [inference]

regulation of cellular ketone metabolic process [inference]

regulation of fatty acid metabolic process

regulation of fatty acid biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of fatty acid biosynthetic process

regulation of small molecule metabolic process [inference]

regulation of cellular ketone metabolic process [inference]

regulation of fatty acid metabolic process

regulation of fatty acid biosynthetic process

positive regulation of small molecule metabolic process [inference]

positive regulation of cholesterol metabolic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of alcohol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

regulation of cholesterol metabolic process [inference]

regulation of cholesterol biosynthetic process

positive regulation of cholesterol biosynthetic process

positive regulation of cholesterol metabolic process [inference]

positive regulation of cholesterol biosynthetic process

regulation of alcohol biosynthetic process [inference]

regulation of cholesterol biosynthetic process

positive regulation of cholesterol biosynthetic process

positive regulation of alcohol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

regulation of primary metabolic process [inference]

regulation of lipid metabolic process [inference]

regulation of fatty acid metabolic process

regulation of fatty acid biosynthetic process

regulation of steroid metabolic process [inference]

positive regulation of steroid metabolic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of sterol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of cholesterol metabolic process [inference]

positive regulation of cholesterol biosynthetic process

regulation of steroid biosynthetic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of sterol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

regulation of sterol biosynthetic process [inference]

regulation of cholesterol biosynthetic process

positive regulation of cholesterol biosynthetic process

positive regulation of sterol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

regulation of cholesterol metabolic process [inference]

regulation of cholesterol biosynthetic process

positive regulation of cholesterol biosynthetic process

positive regulation of cholesterol metabolic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of lipid metabolic process [inference]

positive regulation of steroid metabolic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of sterol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of cholesterol metabolic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of sterol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

regulation of lipid biosynthetic process [inference]

regulation of fatty acid biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of sterol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

regulation of steroid biosynthetic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of sterol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

regulation of sterol biosynthetic process [inference]

regulation of cholesterol biosynthetic process

positive regulation of cholesterol biosynthetic process

positive regulation of sterol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of sterol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of alcohol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of lipid metabolic process [inference]

positive regulation of steroid metabolic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of sterol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of cholesterol metabolic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of steroid biosynthetic process [inference]

positive regulation of sterol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of small molecule metabolic process [inference]

positive regulation of cholesterol metabolic process [inference]

positive regulation of cholesterol biosynthetic process

positive regulation of alcohol biosynthetic process [inference]

positive regulation of cholesterol biosynthetic process

regulation of cellular process [inference]

signal transduction [inference]

ER-nucleus signaling pathway [inference]

SREBP signaling pathway

regulation of cellular metabolic process [inference]

regulation of cellular ketone metabolic process [inference]

regulation of fatty acid metabolic process

regulation of fatty acid biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of fatty acid biosynthetic process

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
Golgi membrane	ISS
Golgi membrane	ISO
endoplasmic reticulum membrane	ISO
endoplasmic reticulum membrane	IDA	12242332
endoplasmic reticulum membrane	IBA

GO Hierarchy

cellular component

protein-containing complex

membrane protein complex [inference]

SREBP-SCAP complex

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

transport vesicle membrane [inference]

ER to Golgi transport vesicle membrane

coated vesicle membrane [inference]

ER to Golgi transport vesicle membrane

bounding membrane of organelle [inference]

Golgi membrane

transport vesicle membrane [inference]

ER to Golgi transport vesicle membrane

coated vesicle membrane [inference]

ER to Golgi transport vesicle membrane

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IPI	12242332
cholesterol binding	TAS	11358865
sterol binding	ISS
protein-containing complex binding	ISO
protein-containing complex binding	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding

lipid binding [inference]

steroid binding [inference]

sterol binding

cholesterol binding

small molecule binding [inference]

alcohol binding [inference]

cholesterol binding

protein-containing complex binding

organic cyclic compound binding [inference]

steroid binding [inference]

sterol binding

cholesterol binding

Gene Ontology information from NCBI Gene and UniProt.

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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External Links

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International Collaboration

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