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phospholipase D family member 3

Summary

Gene Symbol

PLD3

Aliases

HU-K4

Organism

Homo sapiens (human)

External Links

NCBI Gene

23646

HGNC

17158

KEGG Gene ID

hsa:23646

PubChem

23646

Alliance of Genome Resources

HGNC:17158

Annotation

Keyword

3D-structure
Disease variant
Endoplasmic reticulum
Endosome
Exonuclease
Glycoprotein
Golgi apparatus
Immunity
Inflammatory response
Lysosome
Reference proteome
Repeat
Signal-anchor
Spinocerebellar ataxia
Transmembrane helix
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8IV08	Choline phosphatase 3 HindIII K4L homolog Hu-K4 Phosphatidylcholine-hydrolyzing phospholipase D3 Phospholipase D3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
immune system process	IEA
inflammatory response	IEA
myotube differentiation	IDA	22428023
regulation of cytokine production involved in inflammatory response	ISS
DNA metabolic process	IEA

GO Hierarchy

biological process

immune system process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process

cellular developmental process [inference]

cell differentiation [inference]

muscle cell differentiation [inference]

striated muscle cell differentiation [inference]

myotube differentiation

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

muscle cell differentiation [inference]

striated muscle cell differentiation [inference]

myotube differentiation

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

regulation of cytokine production involved in inflammatory response

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

regulation of cytokine production involved in inflammatory response

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

regulation of cytokine production involved in inflammatory response

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

regulation of cytokine production involved in inflammatory response

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

regulation of cytokine production involved in inflammatory response

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GO Term	Evidence Code	PMID
endoplasmic reticulum membrane	IDA	15794758 22428023
late endosome membrane	IDA	29386126
lysosomal membrane	IEA
lysosomal lumen	IDA	30312375
extracellular exosome	HDA	19056867 19199708 23533145

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

endosome membrane [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

vacuolar lumen [inference]

lysosomal lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 3** entries
GO Term	Evidence Code	PMID
phospholipase D activity		9140189
single-stranded DNA 5'-3' DNA exonuclease activity	IDA	30312375
protein binding	IPI	20195357 24336208 32296183

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

nuclease activity [inference]

exonuclease activity [inference]

DNA exonuclease activity [inference]

DNA exonuclease activity, producing 5'-phosphomonoesters [inference]

single-stranded DNA exodeoxyribonuclease activity [inference]

single-stranded DNA 5'-3' DNA exonuclease activity

5'-3' DNA exonuclease activity [inference]

single-stranded DNA 5'-3' DNA exonuclease activity

5'-3' exonuclease activity [inference]

5'-3' DNA exonuclease activity [inference]

single-stranded DNA 5'-3' DNA exonuclease activity

exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters [inference]

DNA exonuclease activity, producing 5'-phosphomonoesters [inference]

single-stranded DNA exodeoxyribonuclease activity [inference]

single-stranded DNA 5'-3' DNA exonuclease activity

5'-3' DNA exonuclease activity [inference]

single-stranded DNA 5'-3' DNA exonuclease activity

DNA nuclease activity [inference]

DNA exonuclease activity [inference]

DNA exonuclease activity, producing 5'-phosphomonoesters [inference]

single-stranded DNA exodeoxyribonuclease activity [inference]

single-stranded DNA 5'-3' DNA exonuclease activity

5'-3' DNA exonuclease activity [inference]

single-stranded DNA 5'-3' DNA exonuclease activity

lipase activity [inference]

phospholipase activity [inference]

phospholipase D activity

phosphoric ester hydrolase activity [inference]

phosphoric diester hydrolase activity [inference]

phospholipase D activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on DNA [inference]

DNA nuclease activity [inference]

DNA exonuclease activity [inference]

DNA exonuclease activity, producing 5'-phosphomonoesters [inference]

single-stranded DNA exodeoxyribonuclease activity [inference]

single-stranded DNA 5'-3' DNA exonuclease activity

5'-3' DNA exonuclease activity [inference]

single-stranded DNA 5'-3' DNA exonuclease activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000105223

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K16860

Name

phospholipase D3/4 [EC:3.1.4.4]

References

Disease

Disease Ontology

Displaying entries **31 - 34** of 34 in total

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DO ID	Disease Name	Source
DOID:9368	keratoconjunctivitis	DisGeNET
DOID:9649	congenital nystagmus	DisGeNET
DOID:9650	pathologic nystagmus	DisGeNET
DOID:9809	hypersensitivity vasculitis	DisGeNET

The Human Phenotype Ontology

Displaying entries **1 - 10** of 13 in total

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HPO ID	HPO Term
HP:0000006	Autosomal dominant inheritance
HP:0000514	Slow saccadic eye movements
HP:0000639	Nystagmus
HP:0001260	Dysarthria
HP:0001272	Cerebellar atrophy
HP:0001310	Dysmetria
HP:0002066	Gait ataxia
HP:0002070	Limb ataxia
HP:0002403	Positive Romberg sign
HP:0003390	Sensory axonal neuropathy

Displaying 1 entry
Disease ID	Disease Name
OMIM:617770	spinocerebellar ataxia 46

PubChem Disease

MedGen Diseases

Spinocerebellar ataxia 46

OMIM Phenotypes

SPINOCEREBELLAR ATAXIA 46; SCA46

KEGG Diseases

Spinocerebellar ataxia (SCA)

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP006669
Gene Name: phospholipase D family, member 3

Ortholog

Displaying entries **1 - 10** of 90 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	179105	WB:WBGene00017316
Drosophila melanogaster	35384	FB:FBgn0032923
Drosophila melanogaster	35387	FB:FBgn0263050
Latimeria chalumnae	102359839		LATCH16692
Danio rerio	571938	ZFIN:ZDB-GENE-050419-212	DANRE13881
Astyanax mexicanus	103043632		ASTMX06315
Ictalurus punctatus	108264303		ICTPU28391
Electrophorus electricus	113580131		ELEEL26090
Esox lucius	105023064		ESOLU01522
Salmo trutta	115163041		SALTR98014

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements