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DNA polymerase alpha 2, accessory subunit

Summary

Gene Symbol

POLA2

Organism

Homo sapiens (human)

External Links

NCBI Gene

23649

PubChem

23649

Alliance of Genome Resources

HGNC:30073

Annotation

Keyword

3D-structure
Alternative splicing
DNA replication
Nucleus
Phosphoprotein
Reference proteome

Proteins

Displaying **all 3** entries
UniProt	Protein Name
A0A9L9PY44
Q14181	DNA polymerase alpha 70 kDa subunit
H0YDR7

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
DNA replication	NAS	8223465
DNA replication, synthesis of RNA primer	IDA	8026492
DNA replication initiation	IDA	26975377
DNA replication initiation	IBA
protein import into nucleus	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein import into nucleus

nuclear transport [inference]

nucleocytoplasmic transport [inference]

import into nucleus [inference]

protein import into nucleus

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to nucleus [inference]

protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to nucleus [inference]

protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

establishment of localization [inference]

transport [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein import into nucleus

nuclear transport [inference]

nucleocytoplasmic transport [inference]

import into nucleus [inference]

protein import into nucleus

organic substance transport [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus

nitrogen compound transport [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein import into nucleus

nuclear transport [inference]

nucleocytoplasmic transport [inference]

import into nucleus [inference]

protein import into nucleus

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein import into nucleus

nuclear transport [inference]

nucleocytoplasmic transport [inference]

import into nucleus [inference]

protein import into nucleus

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to nucleus [inference]

protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

Displaying entries **6 - 8** of 8 in total

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GO Term	Evidence Code	PMID
cytosol	IDA
ciliary basal body	IDA
intracellular membrane-bounded organelle	IDA

GO Hierarchy

cellular component

protein-containing complex [inference]

nuclear protein-containing complex [inference]

nuclear DNA-directed RNA polymerase complex [inference]

alpha DNA polymerase:primase complex

intracellular protein-containing complex [inference]

RNA polymerase complex [inference]

DNA-directed RNA polymerase complex [inference]

nuclear DNA-directed RNA polymerase complex [inference]

alpha DNA polymerase:primase complex

DNA polymerase complex [inference]

alpha DNA polymerase:primase complex

catalytic complex [inference]

transferase complex [inference]

transferase complex, transferring phosphorus-containing groups [inference]

RNA polymerase complex [inference]

DNA-directed RNA polymerase complex [inference]

nuclear DNA-directed RNA polymerase complex [inference]

alpha DNA polymerase:primase complex

DNA polymerase complex [inference]

alpha DNA polymerase:primase complex

cellular anatomical entity [inference]

nucleoplasm

microtubule organizing center [inference]

ciliary basal body

cytosol

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

intracellular organelle [inference]

intracellular membrane-bounded organelle

Displaying **all 2** entries
GO Term	Evidence Code	PMID
DNA binding	IEA
protein binding	IPI	32353859 32814053 33060197 34232536 36217030

GO Hierarchy

molecular function

binding [inference]

protein binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

DNA polymerase

Functional Category

D: Cell cycle control, cell division, chromosome partitioning
L: Replication, recombination and repair
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 3** entries
InterPro
DNA polymerase alpha, subunit B, N-terminal
DNA polymerase alpha, subunit B
DNA polymerase alpha/delta/epsilon, subunit B

Ortholog

Displaying entries **1 - 10** of 64 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	18969		MOUSE26966
Xenopus tropicalis	23649	Xenbase:XB-GENE-5916783
Rattus norvegicus	85242		RATNO18190
Danio rerio	322059		DANRE42648
Pan troglodytes	451318		PANTR03387
Canis lupus familiaris	476025		CANLF06067
Bos taurus	514793		BOVIN23445
Macaca mulatta	716541		MACMU10799
Equus caballus	100051254		HORSE05319
Oryctolagus cuniculus	100355173		RABIT17658

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Acknowledgements