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potassium voltage-gated channel subfamily E regulatory subunit 4

Summary

Gene Symbol

KCNE4

Organism

Homo sapiens (human)

External Links

NCBI Gene

23704

PubChem

23704

Alliance of Genome Resources

HGNC:6244

Annotation

Keyword

Alternative initiation
Glycoprotein
Potassium channel
Reference proteome
Transmembrane helix
Voltage-gated channel

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8WWG9	MinK-related peptide 3 Minimum potassium ion channel-related peptide 3 Potassium channel subunit beta MiRP3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
regulation of ventricular cardiac muscle cell membrane repolarization	IBA
ventricular cardiac muscle cell action potential	IBA
membrane repolarization during action potential	IBA
regulation of heart rate by cardiac conduction	IBA
potassium ion export across plasma membrane	IBA

GO Hierarchy

biological process

cellular process [inference]

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

potassium ion transmembrane transport [inference]

potassium ion export across plasma membrane

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

potassium ion transmembrane transport [inference]

potassium ion export across plasma membrane

export across plasma membrane [inference]

potassium ion export across plasma membrane

export from cell [inference]

export across plasma membrane [inference]

potassium ion export across plasma membrane

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

potassium ion transport [inference]

potassium ion transmembrane transport [inference]

potassium ion export across plasma membrane

monoatomic cation transmembrane transport [inference]

potassium ion transmembrane transport [inference]

potassium ion export across plasma membrane

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

potassium ion transmembrane transport [inference]

potassium ion export across plasma membrane

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

potassium ion transmembrane transport [inference]

potassium ion export across plasma membrane

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

potassium ion transmembrane transport [inference]

potassium ion export across plasma membrane

export across plasma membrane [inference]

potassium ion export across plasma membrane

export from cell [inference]

export across plasma membrane [inference]

potassium ion export across plasma membrane

biological regulation [inference]

regulation of biological process [inference]

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of blood circulation [inference]

regulation of heart contraction [inference]

regulation of heart rate [inference]

regulation of heart rate by cardiac conduction

cardiac conduction [inference]

regulation of heart rate by cardiac conduction

regulation of membrane repolarization [inference]

regulation of cardiac muscle cell membrane repolarization [inference]

regulation of ventricular cardiac muscle cell membrane repolarization

regulation of biological quality [inference]

regulation of heart rate [inference]

regulation of heart rate by cardiac conduction

regulation of membrane potential [inference]

action potential [inference]

cardiac muscle cell action potential [inference]

cardiac muscle cell action potential involved in contraction [inference]

ventricular cardiac muscle cell action potential

regulation of membrane repolarization [inference]

regulation of cardiac muscle cell membrane repolarization [inference]

regulation of ventricular cardiac muscle cell membrane repolarization

membrane repolarization [inference]

membrane repolarization during action potential

membrane repolarization during cardiac muscle cell action potential [inference]

membrane repolarization during ventricular cardiac muscle cell action potential

cardiac muscle cell membrane repolarization [inference]

membrane repolarization during cardiac muscle cell action potential [inference]

membrane repolarization during ventricular cardiac muscle cell action potential

ventricular cardiac muscle cell membrane repolarization [inference]

membrane repolarization during ventricular cardiac muscle cell action potential

Displaying **all 2** entries
GO Term	Evidence Code	PMID
voltage-gated potassium channel complex	IBA
apical plasma membrane	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

voltage-gated potassium channel complex

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

potassium channel complex [inference]

voltage-gated potassium channel complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

potassium channel complex [inference]

voltage-gated potassium channel complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane region [inference]

apical plasma membrane

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
voltage-gated potassium channel activity
delayed rectifier potassium channel activity	IBA
protein binding	IPI	19687231 20533308 32296183
potassium channel regulator activity	IBA
potassium channel inhibitor activity	IDA	27162025

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity

delayed rectifier potassium channel activity

voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [inference]

voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization

monoatomic cation channel activity [inference]

potassium channel activity [inference]

voltage-gated potassium channel activity

delayed rectifier potassium channel activity

voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [inference]

voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity

delayed rectifier potassium channel activity

voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [inference]

voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity [inference]

potassium channel activity [inference]

voltage-gated potassium channel activity

delayed rectifier potassium channel activity

voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [inference]

voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity

delayed rectifier potassium channel activity

voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [inference]

voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization

metal ion transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

potassium channel activity [inference]

voltage-gated potassium channel activity

delayed rectifier potassium channel activity

voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [inference]

voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

potassium channel activity [inference]

voltage-gated potassium channel activity

delayed rectifier potassium channel activity

voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [inference]

voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity

delayed rectifier potassium channel activity

voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [inference]

voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization

monoatomic cation channel activity [inference]

potassium channel activity [inference]

voltage-gated potassium channel activity

delayed rectifier potassium channel activity

voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [inference]

voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity

delayed rectifier potassium channel activity

voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [inference]

voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization

gated channel activity [inference]

voltage-gated channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity

delayed rectifier potassium channel activity

voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [inference]

voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization

salt transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

potassium channel activity [inference]

voltage-gated potassium channel activity

delayed rectifier potassium channel activity

voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [inference]

voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization

binding [inference]

protein binding

transmembrane transporter binding

molecular function regulator activity [inference]

molecular function inhibitor activity [inference]

transporter inhibitor activity [inference]

channel inhibitor activity [inference]

ion channel inhibitor activity [inference]

potassium channel inhibitor activity

transporter regulator activity [inference]

channel regulator activity [inference]

channel inhibitor activity [inference]

ion channel inhibitor activity [inference]

potassium channel inhibitor activity

ion channel regulator activity [inference]

ion channel inhibitor activity [inference]

potassium channel inhibitor activity

potassium channel regulator activity

potassium channel inhibitor activity

transporter inhibitor activity [inference]

channel inhibitor activity [inference]

ion channel inhibitor activity [inference]

potassium channel inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

potassium voltage-gated channel

Functional Category

I: Lipid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 8** entries
Gene Ontology
delayed rectifier potassium channel activity
monoatomic ion transport
potassium channel regulator activity
regulation of heart rate by cardiac conduction
regulation of ventricular cardiac muscle cell membrane repolarization
transmembrane transporter binding
voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
voltage-gated potassium channel activity

Displaying 1 entry
InterPro
Potassium channel, voltage-dependent, beta subunit, KCNE

Ortholog

Displaying entries **1 - 10** of 40 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus laevis	23704	Xenbase:XB-GENE-6487539
Mus musculus	57814	ZFIN:ZDB-GENE-050419-163	MOUSE27374
Rattus norvegicus	367302		RATNO44005
Sus scrofa	397167		PIGXX10080
Bos taurus	615761		BOVIN24830
Pan troglodytes	735608		PANTR29889
Monodelphis domestica	100022621		MONDO31080
Oryctolagus cuniculus	100037711		RABIT12058
Taeniopygia guttata	100224369		TAEGU30378
Pongo abelii	100432203		PONAB23971