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phosphatidylserine decarboxylase

Summary

Gene Symbol

PISD

Aliases

PSDC
dJ858B16.2

Organism

Homo sapiens (human)

External Links

NCBI Gene

23761

HGNC

8999

KEGG Gene ID

hsa:23761

PubChem

23761

Alliance of Genome Resources

HGNC:8999

JoGo

PISD

TogoVar

PISD

Annotation

Keyword

Alternative splicing
Cataract
Cytoplasm
Deafness
Decarboxylase
Disease variant
Dwarfism
Intellectual disability
Lipid droplet
Mitochondrion inner membrane
Phospholipid biosynthesis
Proteomics identification
Pyruvate
Reference proteome
Transit peptide
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9UG56

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
phosphatidylethanolamine biosynthetic process	IMP
phosphatidylethanolamine biosynthetic process	IBA
phosphatidylethanolamine biosynthetic process	IEA
phospholipid biosynthetic process	IEA
regulation of mitochondrion organization	IMP

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

phosphorus metabolic process [inference]

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

mitochondrial protein catabolic process

biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

mitochondrial protein catabolic process

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

protein autoprocessing

protein catabolic process [inference]

mitochondrial protein catabolic process

protein maturation [inference]

protein processing [inference]

protein autoprocessing

primary metabolic process [inference]

lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

lipid biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

protein autoprocessing

protein catabolic process [inference]

mitochondrial protein catabolic process

protein maturation [inference]

protein processing [inference]

protein autoprocessing

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

lipid droplet organization [inference]

lipid droplet formation

organelle assembly [inference]

membraneless organelle assembly [inference]

lipid droplet formation

cellular component assembly [inference]

organelle assembly [inference]

membraneless organelle assembly [inference]

lipid droplet formation

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

regulation of mitochondrion organization

Displaying entries **6 - 10** of 13 in total

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GO Term	Evidence Code	PMID
mitochondrion	HTP
mitochondrial inner membrane	EXP
mitochondrial inner membrane	IEA
Golgi apparatus
lipid droplet	EXP

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

organelle membrane [inference]

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane [inference]

mitochondrial inner membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

membraneless organelle [inference]

intracellular membraneless organelle [inference]

lipid droplet

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular membraneless organelle [inference]

lipid droplet

Displaying **all 4** entries
GO Term	Evidence Code	PMID
phosphatidylserine decarboxylase activity	IMP
phosphatidylserine decarboxylase activity	IBA
phosphatidylserine decarboxylase activity	IEA
protein binding	IPI

GO Hierarchy

molecular function

catalytic activity [inference]

lyase activity [inference]

carbon-carbon lyase activity [inference]

carboxy-lyase activity [inference]

phosphatidylserine decarboxylase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000241878

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K01613

Name

phosphatidylserine decarboxylase [EC:4.1.1.65]

References

Rhea

RHEA:20828

H⁺ + a 1,2-diacyl-sn-glycero-3-phospho-L-serine

CO₂ + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine

Enzyme

4.1.1.65

PMID

Disease

The Human Phenotype Ontology

Displaying entries **1 - 10** of 12 in total

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000252	Microcephaly
HP:0000407	Sensorineural hearing impairment
HP:0000543	Optic disc pallor
HP:0000546	Retinal degeneration
HP:0001249	Intellectual disability
HP:0001263	Global developmental delay
HP:0002650	Scoliosis
HP:0002663	Delayed epiphyseal ossification
HP:0004322	Short stature

Displaying 1 entry
Disease ID	Disease Name
OMIM:618889	Liberfarb syndrome

PubChem Disease

MedGen Diseases

Liberfarb syndrome

OMIM Phenotypes

LIBERFARB SYNDROME; LIBF

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP006744
Gene Name: phosphatidylserine decarboxylase

Ortholog

Displaying 1 entry
Species	Gene ID	Alliance of Genome Resources
Saccharomyces cerevisiae S288C	855552	SGD:S000005113

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements