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fibronectin leucine rich transmembrane protein 3

Summary

Gene Symbol

FLRT3

Organism

Homo sapiens (human)

External Links

NCBI Gene

23767

PubChem

23767

Alliance of Genome Resources

HGNC:3762

Annotation

Keyword

3D-structure
Cell adhesion
Cell junction
Cell membrane
Cell projection
Developmental protein
Disease variant
Disulfide bond
Endoplasmic reticulum
Glycoprotein
Hypogonadotropic hypogonadism
Kallmann syndrome
Leucine-rich repeat
Reference proteome
Repeat
Secreted
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9NZU0	Fibronectin-like domain-containing leucine-rich transmembrane protein 3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
proepicardium cell migration involved in pericardium morphogenesis	ISS
axon guidance	IEA
synapse assembly	ISS
heart development	ISS
fibroblast growth factor receptor signaling pathway	ISS

GO Hierarchy

biological process

cellular process [inference]

cell adhesion [inference]

cell-cell adhesion [inference]

cell-cell adhesion via plasma-membrane adhesion molecules

synaptic membrane adhesion

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

fibroblast growth factor receptor signaling pathway

cell growth [inference]

developmental cell growth [inference]

neuron projection extension

cell motility [inference]

cell migration [inference]

cell migration involved in heart development [inference]

proepicardium cell migration involved in pericardium morphogenesis

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

cell junction assembly [inference]

synapse assembly

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development

neuron projection guidance [inference]

axon guidance

cell junction organization [inference]

cell junction assembly [inference]

synapse assembly

synapse organization [inference]

synapse assembly

developmental process [inference]

anatomical structure morphogenesis [inference]

embryonic morphogenesis

anatomical structure development [inference]

animal organ development [inference]

heart development

head development

growth [inference]

cell growth [inference]

developmental cell growth [inference]

neuron projection extension

developmental growth [inference]

developmental cell growth [inference]

neuron projection extension

developmental growth involved in morphogenesis [inference]

neuron projection extension

locomotion [inference]

taxis [inference]

chemotaxis [inference]

negative chemotaxis

response to stimulus [inference]

response to stress [inference]

response to wounding [inference]

response to axon injury

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

positive regulation of cellular component organization [inference]

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

positive regulation of developmental process [inference]

positive regulation of nervous system development [inference]

positive regulation of synapse assembly

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of synapse assembly

regulation of developmental process [inference]

positive regulation of developmental process [inference]

positive regulation of nervous system development [inference]

positive regulation of synapse assembly

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

positive regulation of nervous system development [inference]

positive regulation of synapse assembly

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

fibroblast growth factor receptor signaling pathway

regulation of cellular component biogenesis [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

positive regulation of synapse assembly

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

positive regulation of cellular component organization [inference]

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

regulation of cellular component organization [inference]

regulation of synapse organization [inference]

regulation of synapse assembly [inference]

positive regulation of synapse assembly

positive regulation of cellular component organization [inference]

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

positive regulation of synapse assembly

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of synapse assembly

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

positive regulation of nervous system development [inference]

positive regulation of synapse assembly

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
extracellular space	IBA
endoplasmic reticulum membrane	IEA
cytosol	IDA
plasma membrane	NAS	10644439
plasma membrane	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

plasma membrane region [inference]

synaptic membrane

postsynaptic membrane

cell junction

synapse [inference]

glutamatergic synapse

anchoring junction [inference]

cell-cell junction

cell-substrate junction [inference]

focal adhesion

external encapsulating structure [inference]

extracellular matrix

site of polarized growth [inference]

growth cone [inference]

axonal growth cone

growth cone membrane

neuron projection terminus [inference]

axon terminus

presynapse [inference]

axon terminus

Displaying **all 5** entries
GO Term	Evidence Code	PMID
fibroblast growth factor receptor binding	IEA
protein binding	IPI	26235030 26960425
protein-macromolecule adaptor activity	NAS	10644439
protein homodimerization activity	IDA	26235030
chemorepellent activity	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

receptor ligand activity [inference]

chemorepellent activity

growth factor receptor binding [inference]

fibroblast growth factor receptor binding

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

molecular adaptor activity [inference]

protein-macromolecule adaptor activity

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

chemorepellent activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

chemorepellent activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Kinase

Functional Category

K: Transcription
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 3** entries
InterPro
Leucine-rich repeat domain superfamily
Leucine-rich repeat, typical subtype
Leucine-rich repeat

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0090093	hypogonadotropic hypogonadism 21 with or without anosmia	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 97 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	23767	Xenbase:XB-GENE-490901
Mus musculus	71436	Xenbase:XB-GENE-490901	MOUSE35580
Rattus norvegicus	366205	Xenbase:XB-GENE-490901	RATNO26540
Xenopus tropicalis	394225	Xenbase:XB-GENE-490901
Pan troglodytes	469886		PANTR24388
Canis lupus familiaris	477149		CANLF09282
Bos taurus	529416		BOVIN04240
Danio rerio	558864		DANRE05610
Macaca mulatta	694694		MACMU01115
Monodelphis domestica	100031549		MONDO08905