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Guidelines

MIRAGE

dedicator of cytokinesis 4

Summary

Gene Symbol

Dock4

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

238130

PubChem

238130

Alliance of Genome Resources

MGI:1918006

Annotation

Keyword

Alternative splicing
Cell membrane
Coiled coil
Cytoplasm
Guanine-nucleotide releasing factor
Phosphoprotein
Proteomics identification
Reference proteome
SH3 domain
SH3-binding

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A1Y7VLY2
P59764

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
small GTPase mediated signal transduction	IEA
cell chemotaxis	ISS
cell chemotaxis	ISO
cell chemotaxis	IBA
regulation of postsynapse assembly	IEA

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

small GTPase mediated signal transduction

cell motility [inference]

cell migration [inference]

cell chemotaxis

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

blood vessel diameter maintenance [inference]

regulation of vasoconstriction [inference]

regulation of vascular associated smooth muscle contraction [inference]

negative regulation of vascular associated smooth muscle contraction

negative regulation of vasoconstriction [inference]

negative regulation of vascular associated smooth muscle contraction

locomotion [inference]

taxis [inference]

chemotaxis [inference]

cell chemotaxis

biological regulation [inference]

regulation of biological process [inference]

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of smooth muscle cell migration [inference]

positive regulation of vascular associated smooth muscle cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of smooth muscle cell migration [inference]

positive regulation of smooth muscle cell migration [inference]

positive regulation of vascular associated smooth muscle cell migration

regulation of vascular associated smooth muscle cell migration [inference]

positive regulation of vascular associated smooth muscle cell migration

positive regulation of cell migration [inference]

positive regulation of smooth muscle cell migration [inference]

positive regulation of vascular associated smooth muscle cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of smooth muscle cell migration [inference]

positive regulation of vascular associated smooth muscle cell migration

positive regulation of biological process [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of smooth muscle cell migration [inference]

positive regulation of vascular associated smooth muscle cell migration

positive regulation of cellular process [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of smooth muscle cell migration [inference]

positive regulation of vascular associated smooth muscle cell migration

negative regulation of biological process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of vasoconstriction [inference]

negative regulation of vascular associated smooth muscle contraction

negative regulation of muscle contraction [inference]

negative regulation of smooth muscle contraction [inference]

negative regulation of vascular associated smooth muscle contraction

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

small GTPase mediated signal transduction

regulation of cellular component biogenesis [inference]

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

regulation of postsynapse assembly

positive regulation of cellular process [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of smooth muscle cell migration [inference]

positive regulation of vascular associated smooth muscle cell migration

regulation of cellular component organization [inference]

regulation of synapse organization [inference]

regulation of synapse assembly [inference]

regulation of postsynapse assembly

regulation of postsynapse organization [inference]

regulation of postsynapse assembly

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

regulation of postsynapse assembly

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of smooth muscle cell migration [inference]

positive regulation of smooth muscle cell migration [inference]

positive regulation of vascular associated smooth muscle cell migration

regulation of vascular associated smooth muscle cell migration [inference]

positive regulation of vascular associated smooth muscle cell migration

positive regulation of cell migration [inference]

positive regulation of smooth muscle cell migration [inference]

positive regulation of vascular associated smooth muscle cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of smooth muscle cell migration [inference]

positive regulation of vascular associated smooth muscle cell migration

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of muscle system process [inference]

regulation of muscle contraction [inference]

regulation of smooth muscle contraction [inference]

regulation of vascular associated smooth muscle contraction [inference]

negative regulation of vascular associated smooth muscle contraction

negative regulation of smooth muscle contraction [inference]

negative regulation of vascular associated smooth muscle contraction

negative regulation of muscle contraction [inference]

negative regulation of smooth muscle contraction [inference]

negative regulation of vascular associated smooth muscle contraction

regulation of blood circulation [inference]

regulation of vasoconstriction [inference]

regulation of vascular associated smooth muscle contraction [inference]

negative regulation of vascular associated smooth muscle contraction

negative regulation of vasoconstriction [inference]

negative regulation of vascular associated smooth muscle contraction

negative regulation of multicellular organismal process [inference]

negative regulation of vasoconstriction [inference]

negative regulation of vascular associated smooth muscle contraction

negative regulation of muscle contraction [inference]

negative regulation of smooth muscle contraction [inference]

negative regulation of vascular associated smooth muscle contraction

regulation of biological quality [inference]

regulation of anatomical structure size [inference]

regulation of tube size [inference]

regulation of tube diameter [inference]

blood vessel diameter maintenance [inference]

regulation of vasoconstriction [inference]

regulation of vascular associated smooth muscle contraction [inference]

negative regulation of vascular associated smooth muscle contraction

negative regulation of vasoconstriction [inference]

negative regulation of vascular associated smooth muscle contraction

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
nucleolus	ISO
nucleolus	IEA
cytoplasm	IBA
Golgi apparatus	ISO
Golgi apparatus	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

plasma membrane

cell junction [inference]

synapse [inference]

glutamatergic synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

stereocilium

actin-based cell projection [inference]

stereocilium

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

nucleolus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular non-membrane-bounded organelle [inference]

nucleolus

postsynapse

cluster of actin-based cell projections [inference]

stereocilium bundle

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
guanyl-nucleotide exchange factor activity	ISS
guanyl-nucleotide exchange factor activity	ISO
guanyl-nucleotide exchange factor activity	IBA
GTPase activator activity	IEA
SH3 domain binding	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

receptor tyrosine kinase binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding [inference]

protein tyrosine kinase binding [inference]

receptor tyrosine kinase binding

GTPase binding [inference]

small GTPase binding

protein domain specific binding [inference]

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

nucleoside-triphosphatase regulator activity [inference]

GTPase regulator activity [inference]

molecular function activator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Dedicator of cytokinesis protein

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
cell migration
myoblast fusion
small GTPase-mediated signal transduction

Displaying entries **1 - 10** of 11 in total

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InterPro
C2 DOCK-type domain
C2 domain superfamily
DOCKER domain
DOCKER, Lobe A
DOCKER, Lobe B
DOCKER, Lobe C
Dedicator of cytokinesis, C-terminal, lobe A
Dedicator of cytokinesis, C-terminal, lobe C
Dedicator of cytokinesis, N-terminal domain
Dedicator of cytokinesis, N-terminal, subdomain 1

Ortholog

Displaying entries **1 - 10** of 79 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Saccharomyces cerevisiae S288C	1793	SGD:S000004414
Saccharomyces cerevisiae S288C	1795	SGD:S000004414
Homo sapiens	9732	Xenbase:XB-GENE-489778	HUMAN90841
Saccharomyces cerevisiae S288C	80005	SGD:S000004414
Saccharomyces cerevisiae S288C	94176	SGD:S000004414
Xenopus tropicalis	238130	Xenbase:XB-GENE-489778
Rattus norvegicus	366608		RATNO36247
Pan troglodytes	463661		PANTR41193
Canis lupus familiaris	482407		CANLF03829
Bos taurus	534227		BOVIN28023

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Last updated: December 8, 2025