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chloride channel accessory 1

Summary

Gene Symbol

Clca1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

23844

PubChem

23844

Alliance of Genome Resources

MGI:1346342

Annotation

Keyword

Autocatalytic cleavage
Calcium transport
Chloride
Glycoprotein
Metal-binding
Metalloprotease
Reference proteome
Secreted
Signal
Zinc

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9D7Z6	Calcium-activated chloride channel family member 3 Protein gob-5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
proteolysis	IEA
chloride transmembrane transport	IEA
chloride transport	ISA	10049711
calcium ion transport	IEA
cellular response to hypoxia	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

cellular process [inference]

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to hypoxia

cellular response to chemical stimulus [inference]

cellular response to oxygen levels [inference]

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

response to stimulus [inference]

response to stress [inference]

response to hypoxia [inference]

cellular response to hypoxia

cellular response to stress [inference]

cellular response to hypoxia

response to abiotic stimulus [inference]

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia [inference]

cellular response to hypoxia

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

cellular response to oxygen levels [inference]

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

response to chemical [inference]

cellular response to chemical stimulus [inference]

cellular response to oxygen levels [inference]

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to hypoxia

cellular response to chemical stimulus [inference]

cellular response to oxygen levels [inference]

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

calcium ion transport

monoatomic anion transport [inference]

chloride transport

chloride transmembrane transport

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic anion transport [inference]

chloride transport

chloride transmembrane transport

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

organic substance transport [inference]

calcium ion transport

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
membrane	IDA	12019299
secretory granule	IDA	12019299
microvillus	IDA	23266329
plasma membrane	IBA
extracellular region	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular region

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

secretory granule membrane [inference]

zymogen granule membrane

bounding membrane of organelle [inference]

secretory granule membrane [inference]

zymogen granule membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

actin-based cell projection [inference]

microvillus

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule

Displaying **all 4** entries
GO Term	Evidence Code	PMID
metal ion binding	IEA
metallopeptidase activity	IEA
intracellular calcium activated chloride channel activity	IBA IEA
chloride channel activity	ISA	10049711

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

metallopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

metallopeptidase activity

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

monoatomic anion channel activity [inference]

chloride channel activity

intracellular chloride channel activity [inference]

intracellular calcium activated chloride channel activity

monoatomic anion transmembrane transporter activity [inference]

monoatomic anion channel activity [inference]

chloride channel activity

intracellular chloride channel activity [inference]

intracellular calcium activated chloride channel activity

chloride transmembrane transporter activity [inference]

chloride channel activity

intracellular chloride channel activity [inference]

intracellular calcium activated chloride channel activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic anion transmembrane transporter activity [inference]

chloride transmembrane transporter activity [inference]

chloride channel activity

intracellular chloride channel activity [inference]

intracellular calcium activated chloride channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

monoatomic anion channel activity [inference]

chloride channel activity

intracellular chloride channel activity [inference]

intracellular calcium activated chloride channel activity

salt transmembrane transporter activity [inference]

chloride transmembrane transporter activity [inference]

chloride channel activity

intracellular chloride channel activity [inference]

intracellular calcium activated chloride channel activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

calcium-activated chloride channel regulator 1

Functional Category

G: Carbohydrate transport and metabolism
H: Coenzyme transport and metabolism
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
chloride transmembrane transport
chloride transport
intracellular calcium activated chloride channel activity
metal ion binding
metallopeptidase activity

Displaying **all 5** entries
InterPro
Calcium-activated chloride channel protein, chordata
Calcium-activated chloride channel, N-terminal
Immunoglobulin-like fold
von Willebrand factor A-like domain superfamily
von Willebrand factor, type A

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:1485	cystic fibrosis	Alliance of Genome Resources
DOID:2841	asthma	Alliance of Genome Resources
DOID:3083	chronic obstructive pulmonary disease	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **107** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	1179		HGNC:2015	HUMAN50639
Rattus norvegicus	308015	10116_1:000f58	RGD:1306258	RATNO24007
Danio rerio	334289		ZFIN:ZDB-GENE-030131-6221	DANRE09301
Sus scrofa	397284			PIGXX24783
Pan troglodytes	456640			PANTR21513
Canis lupus familiaris	490178			CANLF16942
Bos taurus	507643			BOVIN26597
Xenopus tropicalis	594875		Xenbase:XB-GENE-5838950
Monodelphis domestica	100011439			MONDO10517
Ornithorhynchus anatinus	100081190			ORNAN20135

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Last updated: December 9, 2024