GlyCosmos Portal

Annotation

Keyword

3D-structure
Cytoplasm
Dioxygenase
Fatty acid metabolism
Hydrolase
Iron
Membrane
Metal-binding
Phosphoprotein
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
P18054	Arachidonate (12S)-lipoxygenase Arachidonate (15S)-lipoxygenase Linoleate (13S)-lipoxygenase Lipoxin synthase 12-LO Platelet-type lipoxygenase 12

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
superoxide anion generation		15107407
lipid metabolic process	IDA	17493578 18311922 22984144
leukotriene A4 metabolic process	IDA	1851637 8250832
lipoxin A4 biosynthetic process	IDA	8250832
hepoxilin biosynthetic process	ISS

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

fatty acid derivative biosynthetic process [inference]

lipoxin biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

organic hydroxy compound biosynthetic process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

leukotriene metabolic process [inference]

leukotriene A4 metabolic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

long-chain fatty acid biosynthetic process [inference]

linoleic acid metabolic process

hepoxilin metabolic process [inference]

hepoxilin biosynthetic process

leukotriene A4 metabolic process

lipoxin A4 metabolic process [inference]

lipoxin A4 biosynthetic process

lipoxin B4 metabolic process [inference]

lipoxin B4 biosynthetic process

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

unsaturated fatty acid metabolic process

unsaturated fatty acid biosynthetic process [inference]

lipoxin A4 metabolic process [inference]

lipoxin A4 biosynthetic process

lipoxin B4 metabolic process [inference]

lipoxin B4 biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

long-chain fatty acid biosynthetic process [inference]

linoleic acid metabolic process

hepoxilin metabolic process [inference]

hepoxilin biosynthetic process

leukotriene A4 metabolic process

lipoxin A4 metabolic process [inference]

lipoxin A4 biosynthetic process

lipoxin B4 metabolic process [inference]

lipoxin B4 biosynthetic process

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

unsaturated fatty acid metabolic process

unsaturated fatty acid biosynthetic process [inference]

lipoxin A4 metabolic process [inference]

lipoxin A4 biosynthetic process

lipoxin B4 metabolic process [inference]

lipoxin B4 biosynthetic process

lipid modification [inference]

lipid oxidation

fatty acid oxidation

heterocycle metabolic process [inference]

epoxide metabolic process [inference]

leukotriene A4 metabolic process

reactive oxygen species metabolic process [inference]

superoxide metabolic process [inference]

superoxide anion generation

primary metabolic process [inference]

lipid metabolic process

lipid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

fatty acid derivative biosynthetic process [inference]

lipoxin biosynthetic process [inference]

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

long-chain fatty acid biosynthetic process [inference]

linoleic acid metabolic process

hepoxilin metabolic process [inference]

hepoxilin biosynthetic process

leukotriene A4 metabolic process

lipoxin A4 metabolic process [inference]

lipoxin A4 biosynthetic process

lipoxin B4 metabolic process [inference]

lipoxin B4 biosynthetic process

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

unsaturated fatty acid metabolic process

unsaturated fatty acid biosynthetic process [inference]

lipoxin A4 metabolic process [inference]

lipoxin A4 biosynthetic process

lipoxin B4 metabolic process [inference]

lipoxin B4 biosynthetic process

lipid modification [inference]

lipid oxidation

fatty acid oxidation

fatty acid derivative metabolic process [inference]

fatty acid derivative biosynthetic process [inference]

lipoxin biosynthetic process [inference]

leukotriene A4 metabolic process

lipoxin metabolic process [inference]

lipoxin biosynthetic process [inference]

lipoxin A4 metabolic process [inference]

lipoxin A4 biosynthetic process

lipoxin B4 metabolic process [inference]

lipoxin B4 biosynthetic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

leukotriene metabolic process [inference]

leukotriene A4 metabolic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

long-chain fatty acid biosynthetic process [inference]

linoleic acid metabolic process

hepoxilin metabolic process [inference]

hepoxilin biosynthetic process

leukotriene A4 metabolic process

lipoxin A4 metabolic process [inference]

lipoxin A4 biosynthetic process

lipoxin B4 metabolic process [inference]

lipoxin B4 biosynthetic process

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

unsaturated fatty acid metabolic process

unsaturated fatty acid biosynthetic process [inference]

lipoxin A4 metabolic process [inference]

lipoxin A4 biosynthetic process

lipoxin B4 metabolic process [inference]

lipoxin B4 biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

ether metabolic process [inference]

epoxide metabolic process [inference]

leukotriene A4 metabolic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

organic substance metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

leukotriene metabolic process [inference]

leukotriene A4 metabolic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

long-chain fatty acid biosynthetic process [inference]

linoleic acid metabolic process

hepoxilin metabolic process [inference]

hepoxilin biosynthetic process

leukotriene A4 metabolic process

lipoxin A4 metabolic process [inference]

lipoxin A4 biosynthetic process

lipoxin B4 metabolic process [inference]

lipoxin B4 biosynthetic process

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

unsaturated fatty acid metabolic process

unsaturated fatty acid biosynthetic process [inference]

lipoxin A4 metabolic process [inference]

lipoxin A4 biosynthetic process

lipoxin B4 metabolic process [inference]

lipoxin B4 biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

lipid metabolic process

lipid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

fatty acid derivative biosynthetic process [inference]

lipoxin biosynthetic process [inference]

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

long-chain fatty acid biosynthetic process [inference]

linoleic acid metabolic process

hepoxilin metabolic process [inference]

hepoxilin biosynthetic process

leukotriene A4 metabolic process

lipoxin A4 metabolic process [inference]

lipoxin A4 biosynthetic process

lipoxin B4 metabolic process [inference]

lipoxin B4 biosynthetic process

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

unsaturated fatty acid metabolic process

unsaturated fatty acid biosynthetic process [inference]

lipoxin A4 metabolic process [inference]

lipoxin A4 biosynthetic process

lipoxin B4 metabolic process [inference]

lipoxin B4 biosynthetic process

lipid modification [inference]

lipid oxidation

fatty acid oxidation

fatty acid derivative metabolic process [inference]

fatty acid derivative biosynthetic process [inference]

lipoxin biosynthetic process [inference]

leukotriene A4 metabolic process

lipoxin metabolic process [inference]

lipoxin biosynthetic process [inference]

lipoxin A4 metabolic process [inference]

lipoxin A4 biosynthetic process

lipoxin B4 metabolic process [inference]

lipoxin B4 biosynthetic process

ether metabolic process [inference]

epoxide metabolic process [inference]

leukotriene A4 metabolic process

olefinic compound metabolic process [inference]

organic cyclic compound metabolic process [inference]

epoxide metabolic process [inference]

leukotriene A4 metabolic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

fatty acid derivative biosynthetic process [inference]

lipoxin biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

organic hydroxy compound biosynthetic process [inference]

organic hydroxy compound metabolic process [inference]

organic hydroxy compound biosynthetic process [inference]

lipoxin A4 metabolic process [inference]

lipoxin A4 biosynthetic process

lipoxin B4 metabolic process [inference]

lipoxin B4 biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

leukotriene metabolic process [inference]

leukotriene A4 metabolic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

long-chain fatty acid biosynthetic process [inference]

linoleic acid metabolic process

hepoxilin metabolic process [inference]

hepoxilin biosynthetic process

leukotriene A4 metabolic process

lipoxin A4 metabolic process [inference]

lipoxin A4 biosynthetic process

lipoxin B4 metabolic process [inference]

lipoxin B4 biosynthetic process

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

unsaturated fatty acid metabolic process

unsaturated fatty acid biosynthetic process [inference]

lipoxin A4 metabolic process [inference]

lipoxin A4 biosynthetic process

lipoxin B4 metabolic process [inference]

lipoxin B4 biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

long-chain fatty acid biosynthetic process [inference]

linoleic acid metabolic process

hepoxilin metabolic process [inference]

hepoxilin biosynthetic process

leukotriene A4 metabolic process

lipoxin A4 metabolic process [inference]

lipoxin A4 biosynthetic process

lipoxin B4 metabolic process [inference]

lipoxin B4 biosynthetic process

fatty acid biosynthetic process [inference]

unsaturated fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

unsaturated fatty acid metabolic process

unsaturated fatty acid biosynthetic process [inference]

lipoxin A4 metabolic process [inference]

lipoxin A4 biosynthetic process

lipoxin B4 metabolic process [inference]

lipoxin B4 biosynthetic process

lipid modification [inference]

lipid oxidation

fatty acid oxidation

heterocycle metabolic process [inference]

epoxide metabolic process [inference]

leukotriene A4 metabolic process

reactive oxygen species metabolic process [inference]

superoxide metabolic process [inference]

superoxide anion generation

developmental process [inference]

anatomical structure development [inference]

tissue development [inference]

epidermis development [inference]

skin epidermis development [inference]

establishment of skin barrier

epithelium development [inference]

skin epidermis development [inference]

establishment of skin barrier

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-cell adhesion [inference]

negative regulation of homotypic cell-cell adhesion [inference]

negative regulation of platelet aggregation

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of muscle cell apoptotic process

negative regulation of cell activation [inference]

negative regulation of platelet activation [inference]

negative regulation of platelet aggregation

negative regulation of response to stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

negative regulation of platelet activation [inference]

negative regulation of platelet aggregation

negative regulation of response to wounding [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

negative regulation of platelet activation [inference]

negative regulation of platelet aggregation

negative regulation of multicellular organismal process [inference]

negative regulation of coagulation [inference]

negative regulation of blood coagulation [inference]

negative regulation of platelet activation [inference]

negative regulation of platelet aggregation

negative regulation of cell activation [inference]

negative regulation of platelet activation [inference]

negative regulation of platelet aggregation

negative regulation of hemostasis [inference]

negative regulation of blood coagulation [inference]

negative regulation of platelet activation [inference]

negative regulation of platelet aggregation

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

regulation of blood coagulation [inference]

negative regulation of blood coagulation [inference]

negative regulation of platelet activation [inference]

negative regulation of platelet aggregation

negative regulation of response to external stimulus [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

negative regulation of platelet activation [inference]

negative regulation of platelet aggregation

negative regulation of response to stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

negative regulation of platelet activation [inference]

negative regulation of platelet aggregation

negative regulation of response to wounding [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

negative regulation of platelet activation [inference]

negative regulation of platelet aggregation

regulation of response to stress [inference]

regulation of response to wounding [inference]

regulation of wound healing [inference]

regulation of blood coagulation [inference]

negative regulation of blood coagulation [inference]

negative regulation of platelet activation [inference]

negative regulation of platelet aggregation

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

negative regulation of platelet activation [inference]

negative regulation of platelet aggregation

negative regulation of response to wounding [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

negative regulation of platelet activation [inference]

negative regulation of platelet aggregation

regulation of cellular process [inference]

regulation of cell adhesion [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-cell adhesion [inference]

negative regulation of homotypic cell-cell adhesion [inference]

negative regulation of platelet aggregation

regulation of cell-cell adhesion [inference]

negative regulation of cell-cell adhesion [inference]

negative regulation of homotypic cell-cell adhesion [inference]

negative regulation of platelet aggregation

regulation of homotypic cell-cell adhesion [inference]

negative regulation of homotypic cell-cell adhesion [inference]

negative regulation of platelet aggregation

regulation of platelet aggregation [inference]

negative regulation of platelet aggregation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

regulation of muscle cell apoptotic process [inference]

negative regulation of muscle cell apoptotic process

negative regulation of apoptotic process [inference]

negative regulation of muscle cell apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of muscle cell apoptotic process

negative regulation of cellular process [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-cell adhesion [inference]

negative regulation of homotypic cell-cell adhesion [inference]

negative regulation of platelet aggregation

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of muscle cell apoptotic process

negative regulation of cell activation [inference]

negative regulation of platelet activation [inference]

negative regulation of platelet aggregation

regulation of cell activation [inference]

regulation of platelet activation [inference]

negative regulation of platelet activation [inference]

negative regulation of platelet aggregation

regulation of platelet aggregation [inference]

negative regulation of platelet aggregation

negative regulation of cell activation [inference]

negative regulation of platelet activation [inference]

negative regulation of platelet aggregation

regulation of multicellular organismal process [inference]

regulation of coagulation [inference]

regulation of blood coagulation [inference]

negative regulation of blood coagulation [inference]

negative regulation of platelet activation [inference]

negative regulation of platelet aggregation

negative regulation of coagulation [inference]

negative regulation of blood coagulation [inference]

negative regulation of platelet activation [inference]

negative regulation of platelet aggregation

regulation of cell activation [inference]

regulation of platelet activation [inference]

negative regulation of platelet activation [inference]

negative regulation of platelet aggregation

regulation of platelet aggregation [inference]

negative regulation of platelet aggregation

negative regulation of cell activation [inference]

negative regulation of platelet activation [inference]

negative regulation of platelet aggregation

negative regulation of multicellular organismal process [inference]

negative regulation of coagulation [inference]

negative regulation of blood coagulation [inference]

negative regulation of platelet activation [inference]

negative regulation of platelet aggregation

negative regulation of cell activation [inference]

negative regulation of platelet activation [inference]

negative regulation of platelet aggregation

regulation of hemostasis [inference]

regulation of blood coagulation [inference]

negative regulation of blood coagulation [inference]

negative regulation of platelet activation [inference]

negative regulation of platelet aggregation

negative regulation of hemostasis [inference]

negative regulation of blood coagulation [inference]

negative regulation of platelet activation [inference]

negative regulation of platelet aggregation

regulation of biological quality [inference]

regulation of body fluid levels [inference]

regulation of hemostasis [inference]

regulation of blood coagulation [inference]

negative regulation of blood coagulation [inference]

negative regulation of platelet activation [inference]

negative regulation of platelet aggregation

negative regulation of hemostasis [inference]

negative regulation of blood coagulation [inference]

negative regulation of platelet activation [inference]

negative regulation of platelet aggregation

Displaying **all 5** entries
GO Term	Evidence Code	PMID
cytosol	IBA IDA TAS	15107407 8912711
cytoplasm	IDA	8319693
membrane	IDA	8912711
sarcolemma	IBA IDA	15107407
extracellular exosome	HDA	19056867

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane [inference]

sarcolemma

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
hepoxilin-epoxide hydrolase activity	ISS
arachidonate 15-lipoxygenase activity	IBA IDA	17493578 18311922
linoleate 13S-lipoxygenase activity	IBA IDA	8319693
arachidonate 12(S)-lipoxygenase activity	IBA IDA	17493578 18311922 1851637 2217179 22984144 2377602 24282679 8319693
iron ion binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen [inference]

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [inference]

dioxygenase activity [inference]

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [inference]

hydrolase activity [inference]

hydrolase activity, acting on ether bonds [inference]

ether hydrolase activity [inference]

hepoxilin-epoxide hydrolase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

iron ion binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000108839

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K00458

Name

arachidonate 12-lipoxygenase [EC:1.13.11.31]

References

Rhea

RHEA:10428

O₂ + (5Z,8Z,11Z,14Z)-eicosatetraenoate

(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate

Enzyme

1.13.11.31

PMID

RHEA:16869

O₂ + (5Z,8Z,11Z,14Z)-eicosatetraenoate

(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate

Enzyme

1.13.11.33

PMID

Disease

Disease Ontology

Displaying entries **1 - 10** of **198** in total

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DO ID	Disease Name	Source
DOID:8778	Crohn's disease	Alliance of Genome Resources
DOID:0040085	bacterial sepsis	DisGeNET
DOID:0050387	nonpapillary renal cell carcinoma	DisGeNET
DOID:0050572	cone-rod dystrophy	DisGeNET
DOID:0050661	vitelliform macular dystrophy	DisGeNET
DOID:0050865	tongue squamous cell carcinoma	DisGeNET
DOID:0060058	lymphoma	DisGeNET
DOID:0060180	colitis	DisGeNET
DOID:0060189	ileitis	DisGeNET
DOID:0060190	ileocolitis	DisGeNET

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP002105
Gene Name: arachidonate 12-lipoxygenase

Ortholog

Displaying entries **1 - 10** of 63 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Ciona intestinalis	100179479		CIOIN02039
Danio rerio	322732	ZFIN:ZDB-GENE-030131-1452	DANRE41419
Astyanax mexicanus	103037595		ASTMX05645
Ictalurus punctatus	108267744		ICTPU32926
Ictalurus punctatus	108267745		ICTPU32921
Electrophorus electricus	113580793		ELEEL27230
Salmo trutta	115194626		SALTR89929
Salmo trutta	115198574		SALTR64895
Oreochromis niloticus	100698983		ORENI52325
Sparus aurata	115589489		SPAAU08188

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements