GlyCosmos Portal

GlyTouCan

Glycan Structure Repository

GlyComb

Glycoconjugate Repository

GlycoPOST

Glycomics MS raw data Repository

UniCarb-DR

Glycomics MS Repository for glycan annotations from GlycoWorkbench

LM-GlycoRepo

Repository for lectin-assisted multimodality data

All Resources

Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms

Other Information

Release Statistics Download

Tools

Glycan Converters

LM-GlycomeAtlas

Search Tools

Cross Search Glycan Search Publication Search Programmatic Access

Guidelines

MIRAGE

ADAM metallopeptidase with thrombospondin type 1 motif 12

Summary

Gene Symbol

Adamts12

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

239337

PubChem

239337

Alliance of Genome Resources

MGI:2146046

Annotation

Keyword

Alternative splicing
Cleavage on pair of basic residues
Disulfide bond
Extracellular matrix
Glycoprotein
Metal-binding
Metalloprotease
Reference proteome
Repeat
Signal
Zinc
Zymogen

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q3UXR3
Q8BMS3
Q811B3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 33 in total

1

2

3

4

5

…

Next ›

Last »
GO Term	Evidence Code	PMID
ossification	IGI	29618652
chondrocyte differentiation	IGI	29618652
proteoglycan metabolic process	IGI	29618652
proteolysis	IBA
cell-matrix adhesion	ISO

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis involved in protein catabolic process

glycoprotein metabolic process [inference]

proteoglycan metabolic process

proteoglycan catabolic process

glycoprotein catabolic process [inference]

proteoglycan catabolic process

protein catabolic process [inference]

glycoprotein catabolic process [inference]

proteoglycan catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process [inference]

proteoglycan catabolic process

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process [inference]

proteoglycan catabolic process

carbohydrate derivative catabolic process [inference]

glycoprotein catabolic process [inference]

proteoglycan catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process [inference]

proteoglycan catabolic process

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis involved in protein catabolic process

glycoprotein metabolic process [inference]

proteoglycan metabolic process

proteoglycan catabolic process

glycoprotein catabolic process [inference]

proteoglycan catabolic process

protein catabolic process [inference]

glycoprotein catabolic process [inference]

proteoglycan catabolic process

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process [inference]

proteoglycan catabolic process

protein metabolic process [inference]

proteolysis involved in protein catabolic process

glycoprotein metabolic process [inference]

proteoglycan metabolic process

proteoglycan catabolic process

glycoprotein catabolic process [inference]

proteoglycan catabolic process

protein catabolic process [inference]

glycoprotein catabolic process [inference]

proteoglycan catabolic process

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process

proteoglycan catabolic process

glycoprotein catabolic process [inference]

proteoglycan catabolic process

carbohydrate derivative catabolic process [inference]

glycoprotein catabolic process [inference]

proteoglycan catabolic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis involved in protein catabolic process

glycoprotein metabolic process [inference]

proteoglycan metabolic process

proteoglycan catabolic process

glycoprotein catabolic process [inference]

proteoglycan catabolic process

protein catabolic process [inference]

glycoprotein catabolic process [inference]

proteoglycan catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process [inference]

proteoglycan catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process [inference]

proteoglycan catabolic process

carbohydrate derivative catabolic process [inference]

glycoprotein catabolic process [inference]

proteoglycan catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process [inference]

proteoglycan catabolic process

cellular process [inference]

cell adhesion [inference]

cell-substrate adhesion [inference]

cell-matrix adhesion

cellular developmental process [inference]

cell differentiation [inference]

chondrocyte differentiation

cell motility [inference]

cell migration

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

extracellular structure organization [inference]

extracellular matrix organization

collagen fibril organization

external encapsulating structure organization [inference]

extracellular matrix organization

collagen fibril organization

supramolecular fiber organization [inference]

collagen fibril organization

multicellular organismal process [inference]

ossification involved in bone maturation

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

chondrocyte differentiation

response to stimulus [inference]

response to endogenous stimulus [inference]

response to growth factor [inference]

cellular response to growth factor stimulus [inference]

cellular response to BMP stimulus

response to BMP [inference]

cellular response to BMP stimulus

cellular response to endogenous stimulus [inference]

cellular response to growth factor stimulus [inference]

cellular response to BMP stimulus

response to chemical [inference]

response to organic substance [inference]

response to cytokine [inference]

response to tumor necrosis factor [inference]

cellular response to tumor necrosis factor

response to interleukin-1 [inference]

cellular response to interleukin-1

cellular response to cytokine stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of hepatocyte growth factor receptor signaling pathway

regulation of hepatocyte growth factor receptor signaling pathway [inference]

negative regulation of hepatocyte growth factor receptor signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of hepatocyte growth factor receptor signaling pathway

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of hepatocyte growth factor receptor signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of hepatocyte growth factor receptor signaling pathway

negative regulation of cell differentiation [inference]

negative regulation of chondrocyte differentiation

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of hepatocyte growth factor receptor signaling pathway

negative regulation of cellular response to growth factor stimulus [inference]

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of chondrocyte differentiation

negative regulation of cartilage development [inference]

negative regulation of chondrocyte differentiation

negative regulation of multicellular organismal process [inference]

negative regulation of cartilage development [inference]

negative regulation of chondrocyte differentiation

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of hepatocyte growth factor receptor signaling pathway

regulation of hepatocyte growth factor receptor signaling pathway [inference]

negative regulation of hepatocyte growth factor receptor signaling pathway

regulation of response to external stimulus [inference]

regulation of inflammatory response

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of hepatocyte growth factor receptor signaling pathway

negative regulation of cellular response to growth factor stimulus [inference]

regulation of response to stress [inference]

regulation of defense response [inference]

regulation of inflammatory response

regulation of cellular response to growth factor stimulus [inference]

negative regulation of cellular response to growth factor stimulus [inference]

regulation of cellular response to vascular endothelial growth factor stimulus [inference]

negative regulation of cellular response to vascular endothelial growth factor stimulus

regulation of cellular response to hepatocyte growth factor stimulus [inference]

negative regulation of cellular response to hepatocyte growth factor stimulus

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of morphogenesis of an epithelium [inference]

regulation of endothelial tube morphogenesis

regulation of cell differentiation [inference]

regulation of chondrocyte differentiation [inference]

negative regulation of chondrocyte differentiation

negative regulation of cell differentiation [inference]

negative regulation of chondrocyte differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of chondrocyte differentiation

negative regulation of cartilage development [inference]

negative regulation of chondrocyte differentiation

regulation of multicellular organismal development [inference]

regulation of cartilage development [inference]

regulation of chondrocyte differentiation [inference]

negative regulation of chondrocyte differentiation

negative regulation of cartilage development [inference]

negative regulation of chondrocyte differentiation

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of hepatocyte growth factor receptor signaling pathway

regulation of hepatocyte growth factor receptor signaling pathway [inference]

negative regulation of hepatocyte growth factor receptor signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of hepatocyte growth factor receptor signaling pathway

regulation of cell differentiation [inference]

regulation of chondrocyte differentiation [inference]

negative regulation of chondrocyte differentiation

negative regulation of cell differentiation [inference]

negative regulation of chondrocyte differentiation

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of hepatocyte growth factor receptor signaling pathway

negative regulation of cell differentiation [inference]

negative regulation of chondrocyte differentiation

regulation of multicellular organismal process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of cartilage development [inference]

negative regulation of chondrocyte differentiation

regulation of multicellular organismal development [inference]

regulation of cartilage development [inference]

regulation of chondrocyte differentiation [inference]

negative regulation of chondrocyte differentiation

negative regulation of cartilage development [inference]

negative regulation of chondrocyte differentiation

Displaying **all 2** entries
GO Term	Evidence Code	PMID
extracellular region	IEA
extracellular matrix	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular region

external encapsulating structure [inference]

extracellular matrix

Displaying **all 4** entries
GO Term	Evidence Code	PMID
metalloendopeptidase activity	ISO
metalloendopeptidase activity	IBA
metalloendopeptidase activity	IEA
metal ion binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity [inference]

metalloendopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity [inference]

metalloendopeptidase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

A disintegrin and metalloproteinase with thrombospondin motifs

Functional Category

Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
extracellular matrix organization
hydrolase activity
metal ion binding
metalloendopeptidase activity
metallopeptidase activity
proteolysis

Displaying **all 10** entries
InterPro
ADAMTS, cysteine-rich domain 2
ADAMTS/ADAMTS-like, Spacer 1
ADAMTS/ADAMTS-like, cysteine-rich domain 3
ADAMTS/ADAMTS-like
Metallopeptidase, catalytic domain superfamily
PLAC
Peptidase M12B, ADAM/reprolysin
Peptidase M12B, propeptide
Thrombospondin type-1 (TSP1) repeat superfamily
Thrombospondin type-1 (TSP1) repeat

Ortholog

Displaying entries **1 - 10** of 75 in total

1

2

3

4

5

…

Next ›

Last »
Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	11173	FB:FBgn0029791
Caenorhabditis elegans	57188	WB:WBGene00009958
Caenorhabditis elegans	77739	WB:WBGene00009958
Homo sapiens	81792	Xenbase:XB-GENE-959575	HUMAN78761
Caenorhabditis elegans	92949	WB:WBGene00009958
Drosophila melanogaster	108153	FB:FBgn0029791
Drosophila melanogaster	170691	FB:FBgn0029791
Drosophila melanogaster	170692	FB:FBgn0029791
Drosophila melanogaster	171019	FB:FBgn0029791
Homo sapiens	172706	HGNC:14605

About Release Notes Help Feedback

International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

Logo License Policies Site Map

Contact: support@glycosmos.org

GlyCosmos Portal v4.4.0

Last updated: December 8, 2025