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R-spondin 2

Summary

Gene Symbol

Rspo2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

239405

PubChem

239405

Alliance of Genome Resources

MGI:1922667

Annotation

Keyword

3D-structure
Developmental protein
Disulfide bond
Glycoprotein
Heparin-binding
Reference proteome
Secreted
Sensory transduction
Signal
Wnt signaling pathway

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8BFU0	Cysteine-rich and single thrombospondin domain-containing protein 2 Roof plate-specific spondin-2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
embryonic hindlimb morphogenesis	IGI IMP	18256198
epithelial tube branching involved in lung morphogenesis	IMP	18256198
bone mineralization	IGI	19213727
positive regulation of Wnt signaling pathway	ISO
embryonic forelimb morphogenesis	IGI IMP	18256198

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway [inference]

canonical Wnt signaling pathway

cellular developmental process [inference]

cell differentiation [inference]

osteoblast differentiation

neuron differentiation [inference]

dopaminergic neuron differentiation

multicellular organismal process [inference]

morphogenesis of a branching structure [inference]

morphogenesis of a branching epithelium [inference]

branching morphogenesis of an epithelial tube [inference]

epithelial tube branching involved in lung morphogenesis

organ growth [inference]

lung growth

developmental process [inference]

anatomical structure morphogenesis [inference]

morphogenesis of a branching structure [inference]

morphogenesis of a branching epithelium [inference]

branching morphogenesis of an epithelial tube [inference]

epithelial tube branching involved in lung morphogenesis

animal organ morphogenesis [inference]

cartilage morphogenesis [inference]

trachea cartilage morphogenesis

appendage morphogenesis [inference]

limb morphogenesis [inference]

embryonic limb morphogenesis [inference]

forelimb morphogenesis [inference]

embryonic forelimb morphogenesis

hindlimb morphogenesis [inference]

embryonic hindlimb morphogenesis

embryonic appendage morphogenesis [inference]

embryonic limb morphogenesis [inference]

tube morphogenesis [inference]

branching morphogenesis of an epithelial tube [inference]

epithelial tube branching involved in lung morphogenesis

embryonic morphogenesis [inference]

embryonic appendage morphogenesis [inference]

embryonic limb morphogenesis [inference]

tissue morphogenesis [inference]

morphogenesis of an epithelium [inference]

morphogenesis of a branching epithelium [inference]

branching morphogenesis of an epithelial tube [inference]

epithelial tube branching involved in lung morphogenesis

cartilage morphogenesis [inference]

trachea cartilage morphogenesis

anatomical structure development [inference]

tissue development [inference]

biomineral tissue development [inference]

bone mineralization

appendage development [inference]

limb development

cellular developmental process [inference]

cell differentiation [inference]

osteoblast differentiation

neuron differentiation [inference]

dopaminergic neuron differentiation

growth [inference]

developmental growth [inference]

organ growth [inference]

lung growth

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

positive regulation of canonical Wnt signaling pathway

regulation of Wnt signaling pathway [inference]

positive regulation of Wnt signaling pathway

positive regulation of canonical Wnt signaling pathway

regulation of canonical Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

positive regulation of canonical Wnt signaling pathway

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

positive regulation of canonical Wnt signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

positive regulation of canonical Wnt signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

positive regulation of canonical Wnt signaling pathway

negative regulation of biological process [inference]

negative regulation of developmental process [inference]

negative regulation of animal organ morphogenesis [inference]

negative regulation of odontogenesis [inference]

negative regulation of odontogenesis of dentin-containing tooth

negative regulation of multicellular organismal process [inference]

negative regulation of animal organ morphogenesis [inference]

negative regulation of odontogenesis [inference]

negative regulation of odontogenesis of dentin-containing tooth

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

positive regulation of canonical Wnt signaling pathway

regulation of Wnt signaling pathway [inference]

positive regulation of Wnt signaling pathway

positive regulation of canonical Wnt signaling pathway

regulation of canonical Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

positive regulation of canonical Wnt signaling pathway

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of animal organ morphogenesis [inference]

regulation of odontogenesis [inference]

negative regulation of odontogenesis [inference]

negative regulation of odontogenesis of dentin-containing tooth

regulation of odontogenesis of dentin-containing tooth [inference]

negative regulation of odontogenesis of dentin-containing tooth

negative regulation of animal organ morphogenesis [inference]

negative regulation of odontogenesis [inference]

negative regulation of odontogenesis of dentin-containing tooth

negative regulation of developmental process [inference]

negative regulation of animal organ morphogenesis [inference]

negative regulation of odontogenesis [inference]

negative regulation of odontogenesis of dentin-containing tooth

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway [inference]

canonical Wnt signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

positive regulation of canonical Wnt signaling pathway

regulation of Wnt signaling pathway [inference]

positive regulation of Wnt signaling pathway

positive regulation of canonical Wnt signaling pathway

regulation of canonical Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

positive regulation of canonical Wnt signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

positive regulation of canonical Wnt signaling pathway

regulation of multicellular organismal process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of animal organ morphogenesis [inference]

negative regulation of odontogenesis [inference]

negative regulation of odontogenesis of dentin-containing tooth

Displaying **all 3** entries
GO Term	Evidence Code	PMID
extracellular region	IDA	16543246 18256198
cell surface	IDA	18256198
extracellular space	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

Displaying **all 3** entries
GO Term	Evidence Code	PMID
heparin binding	IDA	16543246 18256198
signaling receptor binding	IEA ISO
BMP receptor binding	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding

receptor serine/threonine kinase binding [inference]

transmembrane receptor protein serine/threonine kinase binding [inference]

BMP receptor binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

heparin binding

sulfur compound binding [inference]

heparin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

R-spondin-2

Functional Category

K: Transcription
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
heparin binding

Displaying **all 6** entries
InterPro
Furin-like repeat
Growth factor receptor cysteine-rich domain superfamily
R-spondin, Fu-CRD domain
Spondin-like TSP1 domain
Thrombospondin type-1 (TSP1) repeat superfamily
Thrombospondin type-1 (TSP1) repeat

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0112193	tetraamelia syndrome 2	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **123** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	340419		HGNC:28583	HUMAN95140
Pan troglodytes	464335			PANTR43117
Canis lupus familiaris	482004			CANLF03146
Xenopus tropicalis	496854		Xenbase:XB-GENE-946235
Rattus norvegicus	500863	10116_1:00267f	RGD:1562331	RATNO39116
Bos taurus	536121			BOVIN06068
Danio rerio	566054		ZFIN:ZDB-GENE-060503-667	DANRE11446
Macaca mulatta	697376			MACMU44790
Monodelphis domestica	100024387			MONDO16954
Equus caballus	100056523			HORSE42534