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protein kinase, interferon inducible double stranded RNA dependent activator

Summary

Gene Symbol

Prkra

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

23992

PubChem

23992

Alliance of Genome Resources

MGI:1344375

Annotation

Keyword

Cytoplasm
Phosphoprotein
RNA-binding
RNA-mediated gene silencing
Reference proteome
Repeat

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9WTX2	PKR-associated protein X PKR-associating protein X Protein activator of the interferon-induced protein kinase Protein kinase, interferon-inducible double-stranded RNA-dependent activator

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 10** of 19 in total

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GO Term	Evidence Code	PMID
pre-miRNA processing	ISO
cellular response to oxidative stress	IDA	10336432
miRNA processing	ISO
outer ear morphogenesis	IMP	16571658
middle ear morphogenesis	IMP	16571658

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

innate immune response [inference]

antiviral innate immune response

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

regulatory ncRNA processing [inference]

siRNA processing

miRNA processing

pre-miRNA processing

ncRNA metabolic process [inference]

ncRNA processing [inference]

regulatory ncRNA processing [inference]

siRNA processing

miRNA processing

pre-miRNA processing

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

regulatory ncRNA processing [inference]

siRNA processing

miRNA processing

pre-miRNA processing

ncRNA metabolic process [inference]

ncRNA processing [inference]

regulatory ncRNA processing [inference]

siRNA processing

miRNA processing

pre-miRNA processing

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

regulatory ncRNA processing [inference]

siRNA processing

miRNA processing

pre-miRNA processing

ncRNA metabolic process [inference]

ncRNA processing [inference]

regulatory ncRNA processing [inference]

siRNA processing

miRNA processing

pre-miRNA processing

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

regulatory ncRNA processing [inference]

siRNA processing

miRNA processing

pre-miRNA processing

ncRNA metabolic process [inference]

ncRNA processing [inference]

regulatory ncRNA processing [inference]

siRNA processing

miRNA processing

pre-miRNA processing

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

regulatory ncRNA processing [inference]

siRNA processing

miRNA processing

pre-miRNA processing

ncRNA metabolic process [inference]

ncRNA processing [inference]

regulatory ncRNA processing [inference]

siRNA processing

miRNA processing

pre-miRNA processing

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein phosphorylation

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

regulatory ncRNA processing [inference]

siRNA processing

miRNA processing

pre-miRNA processing

ncRNA metabolic process [inference]

ncRNA processing [inference]

regulatory ncRNA processing [inference]

siRNA processing

miRNA processing

pre-miRNA processing

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

regulatory ncRNA processing [inference]

siRNA processing

miRNA processing

pre-miRNA processing

ncRNA metabolic process [inference]

ncRNA processing [inference]

regulatory ncRNA processing [inference]

siRNA processing

miRNA processing

pre-miRNA processing

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

regulatory ncRNA processing [inference]

siRNA processing

miRNA processing

pre-miRNA processing

ncRNA metabolic process [inference]

ncRNA processing [inference]

regulatory ncRNA processing [inference]

siRNA processing

miRNA processing

pre-miRNA processing

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

regulatory ncRNA processing [inference]

siRNA processing

miRNA processing

pre-miRNA processing

ncRNA metabolic process [inference]

ncRNA processing [inference]

regulatory ncRNA processing [inference]

siRNA processing

miRNA processing

pre-miRNA processing

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

regulatory ncRNA processing [inference]

siRNA processing

miRNA processing

pre-miRNA processing

ncRNA metabolic process [inference]

ncRNA processing [inference]

regulatory ncRNA processing [inference]

siRNA processing

miRNA processing

pre-miRNA processing

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein-RNA complex assembly [inference]

RISC complex assembly

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein-RNA complex assembly [inference]

RISC complex assembly

protein-RNA complex organization [inference]

protein-RNA complex assembly [inference]

RISC complex assembly

developmental process [inference]

anatomical structure morphogenesis [inference]

animal organ morphogenesis [inference]

skeletal system morphogenesis

embryonic morphogenesis [inference]

anatomical structure development [inference]

animal organ development [inference]

sensory organ development [inference]

ear development

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to virus [inference]

defense response to virus [inference]

antiviral innate immune response

defense response to other organism [inference]

innate immune response [inference]

antiviral innate immune response

defense response to symbiont [inference]

defense response to virus [inference]

antiviral innate immune response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

innate immune response [inference]

antiviral innate immune response

defense response to symbiont [inference]

defense response to virus [inference]

antiviral innate immune response

response to oxidative stress [inference]

cellular response to oxidative stress

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

immune response [inference]

innate immune response [inference]

antiviral innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus [inference]

defense response to virus [inference]

antiviral innate immune response

defense response to other organism [inference]

innate immune response [inference]

antiviral innate immune response

defense response to symbiont [inference]

defense response to virus [inference]

antiviral innate immune response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus [inference]

defense response to virus [inference]

antiviral innate immune response

defense response to other organism [inference]

innate immune response [inference]

antiviral innate immune response

defense response to symbiont [inference]

defense response to virus [inference]

antiviral innate immune response

response to chemical [inference]

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of gene silencing by regulatory ncRNA [inference]

regulation of regulatory ncRNA processing

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of regulatory ncRNA processing

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of gene silencing by regulatory ncRNA [inference]

regulation of regulatory ncRNA processing

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of regulatory ncRNA processing

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of gene silencing by regulatory ncRNA [inference]

regulation of regulatory ncRNA processing

regulation of RNA metabolic process [inference]

regulation of regulatory ncRNA processing

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of regulatory ncRNA processing

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of intrinsic apoptotic signaling pathway

positive regulation of apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway

regulation of intracellular signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of intrinsic apoptotic signaling pathway

regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway

regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of intrinsic apoptotic signaling pathway

positive regulation of apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of intrinsic apoptotic signaling pathway

positive regulation of apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of intrinsic apoptotic signaling pathway

positive regulation of apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of intrinsic apoptotic signaling pathway

positive regulation of apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of intrinsic apoptotic signaling pathway

positive regulation of apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway

regulation of intracellular signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of intrinsic apoptotic signaling pathway

regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway

regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of intrinsic apoptotic signaling pathway

positive regulation of apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of intrinsic apoptotic signaling pathway

positive regulation of apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway

regulation of intracellular signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of intrinsic apoptotic signaling pathway

regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway

regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of intrinsic apoptotic signaling pathway

positive regulation of apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of regulatory ncRNA processing

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of gene silencing by regulatory ncRNA [inference]

regulation of regulatory ncRNA processing

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway

regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of intrinsic apoptotic signaling pathway

positive regulation of apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway

regulation of biological quality [inference]

regulation of protein stability [inference]

protein stabilization

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
intracellular anatomical structure	IDA	16571658
nucleus	IBA
nucleoplasm	ISO
nucleoplasm	IEA
cytoplasm	ISS

GO Hierarchy

cellular component

protein-containing complex [inference]

intracellular protein-containing complex [inference]

endonuclease complex [inference]

endoribonuclease complex [inference]

RISC-loading complex

catalytic complex [inference]

endonuclease complex [inference]

endoribonuclease complex [inference]

RISC-loading complex

ribonucleoprotein complex [inference]

RNAi effector complex [inference]

RISC complex

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

perinuclear region of cytoplasm

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
double-stranded RNA binding	ISO
double-stranded RNA binding	IBA
double-stranded RNA binding	IEA
protein binding	IPI	17452327
enzyme binding	ISO

GO Hierarchy

kinase binding [inference]

protein kinase binding

identical protein binding

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding [inference]

double-stranded RNA binding

regulatory RNA binding [inference]

siRNA binding

pre-miRNA binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

kinase activator activity [inference]

protein kinase activator activity

kinase regulator activity [inference]

kinase activator activity [inference]

protein kinase activator activity

protein kinase regulator activity [inference]

protein kinase activator activity

molecular function activator activity [inference]

enzyme activator activity [inference]

kinase activator activity [inference]

protein kinase activator activity

Gene Ontology information from NCBI Gene and UniProt.

Ortholog

Displaying entries **1 - 10** of 69 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	6895	FB:FBgn0032515
Homo sapiens	8575	Xenbase:XB-GENE-940706	HUMAN65779
Xenopus tropicalis	23992	Xenbase:XB-GENE-940706
Bos taurus	282875		BOVIN23986
Rattus norvegicus	311130		RATNO25815
Pan troglodytes	459776		PANTR29245
Danio rerio	557370		DANRE43999
Macaca mulatta	703063		MACMU06077
Monodelphis domestica	100026897		MONDO25008
Equus caballus	100067259		HORSE13210

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