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synaptic Ras GTPase activating protein 1 homolog (rat)

Summary

Gene Symbol

Syngap1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

240057

PubChem

240057

Alliance of Genome Resources

MGI:3039785

Annotation

Keyword

3D-structure
GTPase activation
Membrane
Phosphoprotein
Reference proteome
SH3-binding
Synapse

Proteins

Displaying 1 entry
UniProt	Protein Name
F6SEU4	Neuronal RasGAP Synaptic Ras GTPase-activating protein 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 21 in total

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GO Term	Evidence Code	PMID
Ras protein signal transduction	IDA	15014045
pattern specification process	IMP	16452659
axonogenesis	IDA	15014045
visual learning	IMP	12427827
dendrite development	IMP	15470153

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

small GTPase mediated signal transduction [inference]

Ras protein signal transduction

cell death [inference]

programmed cell death [inference]

apoptotic process [inference]

neuron apoptotic process

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

receptor clustering

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane [inference]

receptor clustering

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

postsynaptic specialization organization [inference]

postsynaptic density organization [inference]

maintenance of postsynaptic specialization structure

cell projection organization [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

axonogenesis

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

dendrite development

cell junction organization [inference]

cell junction maintenance [inference]

maintenance of synapse structure [inference]

maintenance of postsynaptic specialization structure

synapse organization [inference]

maintenance of synapse structure [inference]

maintenance of postsynaptic specialization structure

cellular component maintenance [inference]

cell junction maintenance [inference]

maintenance of synapse structure [inference]

maintenance of postsynaptic specialization structure

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory [inference]

learning [inference]

associative learning [inference]

visual learning

pattern specification process

behavior [inference]

learning or memory [inference]

learning [inference]

associative learning [inference]

visual learning

visual behavior [inference]

visual learning

developmental process [inference]

anatomical structure morphogenesis [inference]

cellular anatomical entity morphogenesis [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

axonogenesis

anatomical structure development [inference]

dendrite development

response to stimulus [inference]

response to abiotic stimulus [inference]

response to radiation [inference]

response to light stimulus [inference]

visual behavior [inference]

visual learning

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane [inference]

receptor clustering

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

receptor clustering

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane [inference]

receptor clustering

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of small GTPase mediated signal transduction [inference]

negative regulation of Ras protein signal transduction

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade

regulation of small GTPase mediated signal transduction [inference]

regulation of Ras protein signal transduction [inference]

negative regulation of Ras protein signal transduction

negative regulation of small GTPase mediated signal transduction [inference]

negative regulation of Ras protein signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of small GTPase mediated signal transduction [inference]

negative regulation of Ras protein signal transduction

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of small GTPase mediated signal transduction [inference]

negative regulation of Ras protein signal transduction

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission

regulation of synaptic plasticity

regulation of neuronal synaptic plasticity [inference]

regulation of long-term neuronal synaptic plasticity

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of small GTPase mediated signal transduction [inference]

negative regulation of Ras protein signal transduction

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of small GTPase mediated signal transduction [inference]

negative regulation of Ras protein signal transduction

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development [inference]

negative regulation of axonogenesis

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of small GTPase mediated signal transduction [inference]

negative regulation of Ras protein signal transduction

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis

negative regulation of multicellular organismal process [inference]

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of small GTPase mediated signal transduction [inference]

negative regulation of Ras protein signal transduction

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade

regulation of small GTPase mediated signal transduction [inference]

regulation of Ras protein signal transduction [inference]

negative regulation of Ras protein signal transduction

negative regulation of small GTPase mediated signal transduction [inference]

negative regulation of Ras protein signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of small GTPase mediated signal transduction [inference]

negative regulation of Ras protein signal transduction

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of small GTPase mediated signal transduction [inference]

negative regulation of Ras protein signal transduction

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of axonogenesis [inference]

negative regulation of axonogenesis

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis

regulation of cell development [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis

regulation of neurogenesis [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

small GTPase mediated signal transduction [inference]

Ras protein signal transduction

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of small GTPase mediated signal transduction [inference]

negative regulation of Ras protein signal transduction

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade

regulation of small GTPase mediated signal transduction [inference]

regulation of Ras protein signal transduction [inference]

negative regulation of Ras protein signal transduction

negative regulation of small GTPase mediated signal transduction [inference]

negative regulation of Ras protein signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of small GTPase mediated signal transduction [inference]

negative regulation of Ras protein signal transduction

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of small GTPase mediated signal transduction [inference]

negative regulation of Ras protein signal transduction

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission

regulation of synaptic plasticity

regulation of neuronal synaptic plasticity [inference]

regulation of long-term neuronal synaptic plasticity

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

regulation of neuron apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis

regulation of cell development [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis

regulation of neurogenesis [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of small GTPase mediated signal transduction [inference]

negative regulation of Ras protein signal transduction

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development [inference]

negative regulation of axonogenesis

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development [inference]

negative regulation of axonogenesis

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

negative regulation of neuron projection development [inference]

negative regulation of axonogenesis

regulation of axonogenesis [inference]

negative regulation of axonogenesis

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development [inference]

negative regulation of axonogenesis

regulation of multicellular organismal process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis

regulation of biological quality [inference]

regulation of synaptic plasticity

regulation of neuronal synaptic plasticity [inference]

regulation of long-term neuronal synaptic plasticity

regulation of synapse structure or activity

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
plasma membrane	IEA
postsynaptic density	IDA	17114649
membrane	IDA	15014045
dendritic shaft	IDA	16452659
synapse	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

cell junction [inference]

synapse

glutamatergic synapse

dendritic shaft

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

postsynaptic specialization, intracellular component [inference]

postsynaptic density, intracellular component

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

postsynaptic specialization, intracellular component [inference]

postsynaptic density, intracellular component

postsynaptic specialization [inference]

postsynaptic density

Displaying **all 5** entries
GO Term	Evidence Code	PMID
GTPase activator activity	ISO
GTPase activator activity	IDA	15014045
protein binding	IPI	15014045 27086544 28671696 38452102
SH3 domain binding	IEA
protein kinase binding	ISO

GO Hierarchy

molecular function

binding [inference]

protein binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding

protein domain specific binding [inference]

SH3 domain binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

nucleoside-triphosphatase regulator activity [inference]

GTPase regulator activity [inference]

GTPase activator activity

molecular function activator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Ras/Rap GTPase-activating protein SynGAP

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 5** entries
InterPro
C2 domain superfamily
C2 domain
Ras GTPase-activating domain
Ras GTPase-activating protein
Rho GTPase activation protein

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:5419	schizophrenia	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 63 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	8831	Xenbase:XB-GENE-487270	HUMAN84342
Saccharomyces cerevisiae S288C	9462	SGD:S000001575
Saccharomyces cerevisiae S288C	64926	SGD:S000001575
Saccharomyces cerevisiae S288C	69601	SGD:S000001575
Rattus norvegicus	192117		RATNO22440
Xenopus tropicalis	240057	Xenbase:XB-GENE-487270
Macaca mulatta	717858		MACMU34346
Bos taurus	790307		BOVIN18298
Xenopus tropicalis	853770	Xenbase:XB-GENE-487270
Monodelphis domestica	100027431		MONDO13143

GlyTouCan

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UniCarb-DR

LM-GlycoRepo

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OrthoDB (Group)

International Collaboration

Acknowledgements