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sodium channel, voltage-gated, type XI, alpha

Summary

Gene Symbol

Scn11a

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

24046

PubChem

24046

Alliance of Genome Resources

MGI:1345149

Annotation

Keyword

Cell membrane
Disulfide bond
Glycoprotein
Reference proteome
Repeat
Sodium channel
Transmembrane helix
Voltage-gated channel

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9R053	NaN Sensory neuron sodium channel 2 Sodium channel protein type XI subunit alpha Voltage-gated sodium channel subunit alpha Nav1.9

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 51 in total

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GO Term	Evidence Code	PMID
action potential	IMP	30395542
thigmotaxis	IMP	31534133
acute inflammatory response	IMP	31534133
chronic inflammatory response	IMP	31534133
sodium ion transport	IDA	16029194

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

leukocyte degranulation [inference]

mast cell degranulation

cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

calcitonin family receptor signaling pathway [inference]

calcitonin gene-related peptide receptor signaling pathway

vesicle-mediated transport [inference]

exocytosis [inference]

regulated exocytosis [inference]

leukocyte degranulation [inference]

mast cell degranulation

cell motility

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to cold

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

axonogenesis

export from cell [inference]

secretion by cell [inference]

exocytosis [inference]

regulated exocytosis [inference]

leukocyte degranulation [inference]

mast cell degranulation

multicellular organismal process [inference]

system process [inference]

muscle system process [inference]

muscle contraction [inference]

smooth muscle contraction [inference]

small intestine smooth muscle contraction

renal system process [inference]

micturition

excretion [inference]

micturition

nervous system process [inference]

sensory perception [inference]

transmission of nerve impulse

behavior [inference]

thigmotaxis

chemosensory behavior

behavioral response to chemical pain [inference]

thermosensory behavior

behavioral response to pain

behavioral response to chemical pain [inference]

multicellular organismal response to stress [inference]

response to pain

developmental process [inference]

anatomical structure morphogenesis [inference]

cellular anatomical entity morphogenesis [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

axonogenesis

anatomical structure development [inference]

blood vessel development [inference]

artery development

animal organ development [inference]

muscle organ development [inference]

skeletal muscle organ development

muscle structure development [inference]

muscle organ development [inference]

skeletal muscle organ development

rhythmic process [inference]

circadian rhythm

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response

response to heat

response to cold

cellular response to cold

cellular response to stress [inference]

cellular response to cold

multicellular organismal response to stress [inference]

response to pain

response to external stimulus [inference]

detection of external stimulus [inference]

detection of temperature stimulus [inference]

detection of temperature stimulus involved in sensory perception [inference]

detection of temperature stimulus involved in sensory perception of pain

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception

detection of mechanical stimulus involved in sensory perception of pain

response to mechanical stimulus [inference]

response to auditory stimulus

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception

detection of mechanical stimulus involved in sensory perception of pain

reflex

response to abiotic stimulus [inference]

response to temperature stimulus [inference]

response to heat

response to cold

cellular response to cold

detection of temperature stimulus [inference]

detection of temperature stimulus involved in sensory perception [inference]

detection of temperature stimulus involved in sensory perception of pain

thermosensory behavior

response to radiation [inference]

response to light stimulus [inference]

response to light intensity [inference]

response to high light intensity

detection of abiotic stimulus [inference]

detection of temperature stimulus [inference]

detection of temperature stimulus involved in sensory perception [inference]

detection of temperature stimulus involved in sensory perception of pain

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception

detection of mechanical stimulus involved in sensory perception of pain

response to mechanical stimulus [inference]

response to auditory stimulus

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception

detection of mechanical stimulus involved in sensory perception of pain

response to endogenous stimulus [inference]

response to hormone [inference]

response to prostaglandin [inference]

response to prostaglandin E

response to chemical [inference]

response to organic substance [inference]

response to hormone [inference]

response to prostaglandin [inference]

response to prostaglandin E

response to organonitrogen compound [inference]

response to cyclophosphamide

response to lipid [inference]

response to prostaglandin [inference]

response to prostaglandin E

response to alcohol [inference]

response to prostaglandin E

response to ketone [inference]

response to prostaglandin E

response to inorganic substance [inference]

response to nitric oxide

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to cyclophosphamide

response to nitric oxide

response to oxygen-containing compound [inference]

response to nitric oxide

response to alcohol [inference]

response to prostaglandin E

response to ketone [inference]

response to prostaglandin E

detection of stimulus [inference]

detection of external stimulus [inference]

detection of temperature stimulus [inference]

detection of temperature stimulus involved in sensory perception [inference]

detection of temperature stimulus involved in sensory perception of pain

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception

detection of mechanical stimulus involved in sensory perception of pain

detection of abiotic stimulus [inference]

detection of temperature stimulus [inference]

detection of temperature stimulus involved in sensory perception [inference]

detection of temperature stimulus involved in sensory perception of pain

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception

detection of mechanical stimulus involved in sensory perception of pain

detection of stimulus involved in sensory perception [inference]

detection of temperature stimulus involved in sensory perception [inference]

detection of temperature stimulus involved in sensory perception of pain

detection of mechanical stimulus involved in sensory perception

detection of mechanical stimulus involved in sensory perception of pain

detection of stimulus involved in sensory perception of pain [inference]

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to cold

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

sodium ion transport

sodium ion transmembrane transport

calcium ion transport [inference]

calcium ion transmembrane transport

monoatomic cation transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

vesicle-mediated transport [inference]

exocytosis [inference]

regulated exocytosis [inference]

leukocyte degranulation [inference]

mast cell degranulation

secretion [inference]

secretion by cell [inference]

exocytosis [inference]

regulated exocytosis [inference]

leukocyte degranulation [inference]

mast cell degranulation

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

organic substance transport [inference]

calcium ion transport [inference]

calcium ion transmembrane transport

export from cell [inference]

secretion by cell [inference]

exocytosis [inference]

regulated exocytosis [inference]

leukocyte degranulation [inference]

mast cell degranulation

establishment of localization in cell

leukocyte degranulation [inference]

mast cell degranulation

establishment of organelle localization [inference]

mast cell degranulation

organelle localization [inference]

establishment of organelle localization [inference]

mast cell degranulation

vacuolar localization [inference]

lysosome localization [inference]

mast cell degranulation

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

calcitonin family receptor signaling pathway [inference]

calcitonin gene-related peptide receptor signaling pathway

regulation of biological quality [inference]

regulation of membrane potential

action potential

membrane depolarization [inference]

membrane depolarization during action potential

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
voltage-gated sodium channel complex	IBA
voltage-gated sodium channel complex	IEA
plasma membrane	ISO
plasma membrane	IDA	16029194
plasma membrane	IMP	24036948

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

voltage-gated sodium channel complex

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

sodium channel complex [inference]

voltage-gated sodium channel complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

sodium channel complex [inference]

voltage-gated sodium channel complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

synaptic membrane [inference]

presynaptic membrane

cell junction [inference]

synapse [inference]

glutamatergic synapse

site of polarized growth [inference]

growth cone [inference]

axonal growth cone

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon

C-fiber

cell body

neuronal cell body

Displaying **all 5** entries
GO Term	Evidence Code	PMID
voltage-gated sodium channel activity	ISO
voltage-gated sodium channel activity	IDA	16029194
voltage-gated sodium channel activity	IMP	24036948
voltage-gated sodium channel activity	IBA
protein binding	IPI	11376006

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

monoatomic cation channel activity [inference]

sodium channel activity [inference]

voltage-gated sodium channel activity

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity [inference]

sodium channel activity [inference]

voltage-gated sodium channel activity

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

sodium channel activity [inference]

voltage-gated sodium channel activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

sodium channel activity [inference]

voltage-gated sodium channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

monoatomic cation channel activity [inference]

sodium channel activity [inference]

voltage-gated sodium channel activity

salt transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

sodium channel activity [inference]

voltage-gated sodium channel activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

sodium channel protein

Functional Category

E: Amino acid transport and metabolism
K: Transcription
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
membrane depolarization during action potential
monoatomic ion channel activity
monoatomic ion transport
neuronal action potential
sodium channel activity
sodium ion transmembrane transport
voltage-gated sodium channel activity

Displaying **all 7** entries
InterPro
Ion transport domain
Sodium ion transport-associated domain
Voltage gated sodium channel, alpha subunit
Voltage-dependent channel domain superfamily
Voltage-gated Na+ ion channel, cytoplasmic domain
Voltage-gated cation channel calcium and sodium
Voltage-gated sodium channel alpha subunit, inactivation gate

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0050548	hereditary sensory neuropathy	Alliance of Genome Resources
DOID:0111731	familial episodic pain syndrome 3	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements